A Human Protein with Sequence Similarity to <i>Drosophila</i> Mastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters

Kitagawa, Motoo; Oyama, Toshinao; Kawashima, Takayuki; Yedvobnick, Barry; Kumar, Anumeha; Matsuno, Kenji; Harigaya, Kenichi

doi:10.1128/mcb.21.13.4337-4346.2001

Cited by 112 publications

(136 citation statements)

References 37 publications

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“…The Mastermind homologues have been identified in Drosophila (Yedvobnick et al, 1988;Smoller et al, 1990), C. elegans (Petcherski and Kimble, 2000b), Xenopus (Katada and Kinoshita, 2003), mouse (Petcherski and Kimble, 2000b; and human (Wu et al, 2000(Wu et al, , 2002Kitagawa et al, 2001;Lin et al, 2002). The Mastermind (mam) gene first was identified in Drosophila as one of the original group of 'neurogenic' loci along with Notch, and loss of the function of Mam resulted in excessive neural cells at the expense of epithelial cells (Yedvobnick et al, 1988;, indicating that the molecule regulated neuronal cell-fate decisions.…”

Section: Identification Of Maml Proteins and Investigations Into Theimentioning

confidence: 99%

Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

2008

Oncogene

135

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Section: Identification Of Maml Proteins and Investigations Into Theimentioning

confidence: 99%

Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

2008

Oncogene

135

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“…Since the binding of i.c. Notch-1 to RBP-Jk has been proposed to be crucial for recruitment of the coactivating MAML complex (Kitagawa et al, 2001), the induction of i.c. Notch-1 would act in concert with reduced HDAC activity, further inducing the expression of Hes-1.…”

Section: Vpa Modulates the Notch Signalling Cascade In Nb Cellsmentioning

confidence: 99%

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells

et al. 2005

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Neuroblastoma (NB), a sympathetically derived childhood tumour, shows characteristics of neuronal precursor cells, suggesting a halted differentiation process. We have previously shown that the Notch signalling cascade, a key player during normal neurogenesis, also might be involved in NB differentiation. Valproic acid (VPA), a well-tolerated antiepileptic drug, has been shown to induce differentiation and cell death of NB cells, possibly associated with its recently described HDAC inhibiting activity. Stimulation of NB cells with VPA led to increased cell death and phenotypic changes associated with differentiation, that is, neurite extension and upregulation of neuronal markers. VPA treatment also led to an activated Notch signalling cascade as shown by increased levels of intracellular Notch-1 and Hes-1, mimicking the initial phase of induced differentiation. These results reinforce that VPA potentially could be used in differentiation therapy of NB and that the effects in part could be a consequence of interference with the Notch signalling cascade.

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“…The firefly luciferase activity was normalized by the Renilla luciferase control activity. Values were expressed as the mean relative stimulation and SD for representative experiments (19). Data were analyzed as the fold induction of luciferase activity over unstimulated cells and are representative of the average of three identical experiments.…”

Section: Transcriptional Transactivation Assays (Luciferase Assays)mentioning

confidence: 99%

“…Lysates were incubated with an anti-Flag Ab (M2; Sigma-Aldrich) or an anti-HA Ab (12CA5) as a control. Immune complexes were precipitated with protein G-Sepharose (Amersham Biosicences) and analyzed with anti-Flag and anti-CD44 (Hermes3) Abs as described previously (19).…”

Section: Western Blotting and Immunoprecipitationmentioning

confidence: 99%

CD44 Suppresses TLR-Mediated Inflammation

Kawana

Karaki

Higashi

et al. 2008

The Journal of Immunology

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The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies have revealed that CD44 plays crucial roles in a variety of inflammatory diseases. In recent years, TLRs, which are ancient microbial pattern recognition receptors, have been shown to initiate an innate immune response and have been linked to a variety of inflammatory diseases. The present study shows that CD44 negatively regulates in vivo inflammation mediated by TLRs via NF-κB activation, which leads to proinflammatory cytokine production. Furthermore, our results show that CD44 directly associates with TLR2 when stimulated by the TLR2 ligand zymosan and that the cytoplasmic domain of CD44 is crucial for its regulatory effect on TLR signaling. This study indicates that CD44 plays a protective role in TLR-mediated inflammation and is the first to demonstrate a direct association between CD44 and a TLR.

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A Human Protein with Sequence Similarity to Drosophila Mastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters

Cited by 112 publications

References 37 publications

Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells

CD44 Suppresses TLR-Mediated Inflammation

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