A human model of Buruli ulcer: Provisional protocol for a Mycobacterium ulcerans controlled human infection study.
Stephen Muhi,
Julia L. Marshall,
Daniel P. O'Brien
et al.
Abstract:Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been proposed as an experimental platform to explore host-pathogen interactions and evaluate tools for prevention, diagnosis, and treatment. We have previously introduced the use case for a new human model and identified M. ulcerans JKD8049 as a suitable challenge stra… Show more
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