A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

Goldstein, Leslie A.; Zhou, Daqing; Picker, Louis J.; Minty, C.; Bargatze, Robert F.; Ding, Jie; Butcher, Eugene C.

doi:10.1016/0092-8674(89)90639-9

Cited by 517 publications

(278 citation statements)

References 37 publications

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“…gp90HR Ka " T «> is indistinguishable from CD44(Pgp-1) antigen (8)(9)(10)(11)(12)(13)(14)(15)(16); this report) Although human gp90HR Herm8S shares MEL-14 antibody epitope with mouse gp90HR MEL14 they are structurally distinct (7,(17)(18)(19)(20). Both gp90HRs appear to mediate specific binding for endothelium and have therefore been implicated in T and B lymphocyte traffic (6,7) It is generally assumed that gp90HRs are acquired during B and T cell development in bone marrow and thymus respectively (6), and that CD44 in normal human thymus is associated with thymocyte functional maturation and location in the medulla (14) In spite of this knowledge, very little is known about the role of such receptors (and their ligands) in T cell precursor migration, commitment to T cell lineage, and intrathymic cell traffic.…”

Section: Introductionmentioning

confidence: 99%

Function of CD44(Pgp-1) homing receptor in human T cell precursors

Hera¹,

Acevedo²,

Marston³

et al. 1989

Int Immunol

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T cell precursors migrate from extrathymlc hematopoietic tissues and differentiate after encountering the thymic mlcroenvlronment. We asked whether human T cell precursors express the CD44(Pgp-1/gp90HR) class of homing receptors that have been implicated in the traffic of hematopoietic cells, such as lymphocyte entry to peripheral lymphoid organs. Flow cytometry and immunopreclpltatlon studies demonstrate that CD7+34+, CD1 -2-3-4-8-14-16-20-cells In bone marrow and thymus, which have been shown to exhibit features of T cell precursors, bear CD44. Immunohlstologlcal studies show that clusters of thymocytes in the subcapsular and the Inner cortex and most medullary thymocytes are clearly CD44 + , whereas the expression of CD44 is selectively downregulated in CD3-and CD3 low functionally Incompetent cortical thymocytes. The expression of CD44 Is not restricted to T cell precursors but also occurs In thymic stroma, which bear a different molecular species of CD44. CD44-specific antibodies exert stimulatory effects on T cell precursors, a process that is dependent on stromal cells. We postulate that CD44 might be an adhesion molecule for precursor homing to thymus and that it participates In cell-to-cell interactions within the thymic environment.

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Section: Introductionmentioning

confidence: 99%

Function of CD44(Pgp-1) homing receptor in human T cell precursors

Hera¹,

Acevedo²,

Marston³

et al. 1989

Int Immunol

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“…In humans three polyadenylation sites are present and in usage, giving rise to RNAs of 1.5; 2.2 and 4.5 kb length (Goldstein et al, 1989;Stamenkovic et al, 1991;Harn et al, 1991). In the mouse there is evidence for four polyadenylation sites, which generate RNAs of 1.6; 3.2; 4.0 and 5.2 kb (Wolffe et al, 1990).…”

Section: Genomic Organization Of the Cd44 Genementioning

confidence: 99%

“…Binding to hyaluronic acid has initially been postulated due to the homology of the amino terminal CD44 region to the HA binding domains of cartilage proteoglycan core and link proteins (Stamenkovic et al, 1989;Goldstein et al, 1989). Hyaluronic acid is a polysaccharide of high molecular mass located in the extracellular matrix (ECM).…”

Section: Functional Implications Of the Cd44 Isoformsmentioning

confidence: 99%

“…The interaction between CD44S and HEV can be blocked with mAb Hermes-3 (Jalkanen et al, 1987), which recognizes an epitope in the membrane proximal region near the insertion site for exons 1v to 10v (Goldstein et al, 1989).…”

Section: Functional Implications Of the Cd44 Isoformsmentioning

confidence: 99%

“…When the human, baboon and murine cDNA sequences were established identity was confirmed. However, the cDNA sequence codes only for about 360 amino acids, revealing a just 37 kD encompassing protein core (Stamenkovic et al, 1989;Goldstein et al, 1989;Idzerda et al, 1989;Nottenburg et al, 1989;Zhou et al, 1989;Wolffe et al, 1990). This protein core is highly glycosylated by N-and O-linked sugars to yield a 85 to 90 kD form and is sometimes additionally linked to chondroitin sulfate side chains to produce a 180 -200 kD form (Jalkanen et al, 1988;Stamenkovic et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CD44: A Multitude of Isoforms with Diverse Functions

Günthert¹

1993

Current Topics in Microbiology and Immunology

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Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions

Bajorath

2000

Proteins

139

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CD44 is a type I transmembrane protein and member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. CD44 is a major cell surface receptor for hyaluronan, a component of the extracellular matrix. It is implicated in diseases such as cancer and inflammation and therefore intensely studied. A characteristic feature of CD44 is the occurrence of many isoforms that are expressed in a cell-specific manner and differentially glycosylated. Although a number of CD44 isoforms have been characterized, the structural diversity of CD44 makes it often challenging to study (isoform-specific) CD44-ligand interactions at the molecular level of detail. The structural organization and ligand binding characteristics of CD44 are focal points of this review. On the basis of recent structural and mutagenesis studies, details of the CD44-hyaluronan interaction are beginning to be understood. Proteins 2000;39:103-111.

show abstract

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

Cited by 517 publications

References 37 publications

Function of CD44(Pgp-1) homing receptor in human T cell precursors

Function of CD44(Pgp-1) homing receptor in human T cell precursors

CD44: A Multitude of Isoforms with Diverse Functions

Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions

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