A Human Lactobacillus Strain (Lactobacillus Gg) Promotes Recovery From Acute Diarrhoea in Children

Isolauri, Erika; Jalonen, Tuula O.; Juntunen, Miia; Rautanen, Tarja; Koivula, Timo

doi:10.1203/00006450-199005000-00026

Cited by 269 publications

(354 citation statements)

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“…During the last 10 years it has been demonstrated in several studies that probiotic strains of lactobacilli, consumed via dairy products or given as freeze-dried preparations, may decrease the duration of diarrhoeal disease in children with intestinal infections (particularly with rotavirus) and in people with diarrhoea associated with antibiotic treatment (Siitonen et al, 1990;Isolauri et al, 1991Isolauri et al, , 1994Kaila et al, 1992;Sheen et al, 1995). In addition, it has been demonstrated that probiotic lactobacilli may modulate parameters of the immune system (Perdigon et al, 1990;Sanders, 1993;Kaila et al, 1995;Pouwels et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…The immunomodulating properties of lactobacilli and the possible mechanisms and effects in relation to intestinal infections have been reviewed by Havanaar & Spanhaak (1994). In mouse experiments (Perdigon et al, 1990;Pouwels et al, 1996) as well as in human studies (DeSimone et al, 1988;Isolauri et al, 1991;Kaila et al, 1992), the oral intake of lactobacilli resulted in stimulation of macrophages, lymphocytes and natural killer (NK) cells, higher production of g-interferon and signi®cantly higher secretory IgA responses against pathogenic agents (Salmonella, Rotavirus).…”

Section: Introductionmentioning

confidence: 99%

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The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

1998

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Objective: To determine the effect of consumption of milk fermented by Lactobacillus casei strain Shirota (L. casei Shirota) on the composition and metabolic activities of the intestinal micro¯ora, and immune parameters in humans. Subjects: Twenty healthy male subjects aged 40±65 years were selected. Design: A placebo-controlled trial was performed in which 10 subjects were randomly assigned to a control and 10 to a treatment group. During the ®rst and last two weeks of the 8-week study the subjects received a strictly controlled diet without fermented products. The same controlled diet was given during the intermediate 4-week test period but then the treatment group received three times daily 100 ml of fermented milk containing 10 9 CFU L. casei Shirotaaml, whereas the same amount of unfermented milk was given to the subjects in the control group. Results: In comparison to the control group, the consumption of L. casei Shirota-fermented milk resulted in an increase of the Lactobacillus count in the faeces in which the administered L. casei Shirota was predominant at the level of 10 7 CFUag wet faeces. This was associated with a signi®cant increase in Bi®dobacterium counts (P`0.05). Some shifts in the other bacterial species were found, such as a decreased number of Clostridium; however the differences were not statistically different between the treatment and the control groups.The b-glucuronidase and b-glucosidase activities per 10 10 bacteria decreased signi®cantly (P`0.05) at the second week of the 4-week test period with the consumption of L. casei Shirota-fermented milk. Furthermore, the consumption of the fermented milk product resulted in a slight but signi®cant increase in the moisture content of the faecal samples (P`0.05). No treatment effects were observed for any of the immune parameters measured (including natural killer (NK) cell activity, phagocytosis and cytokine production). Conclusions:The results suggest that consumption of L. casei Shirota-fermented milk is able to modulate the composition and metabolic activity of the intestinal¯ora and indicate that L. casei Shirota-fermented milk does not in¯uence the immune system of healthy immunocompetent males.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

1998

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“…Probiotics has been suggested as a mode of preventing or moderating the infection. The group of Isolauri et al (1991) has reported a positive effect of a human lactic acid bacterial species, Lactobacilli casei strain gg, on the recovery from acute rotavirus induced diarrhoea in children. The children were randomised to either a lactic acid bacteria fermented milk product containing 10 10 ± 11 Lactobacillus casei, a Lactobacillus casei freeze-dried powder (10 10 ± 11 ), or placebo (pasteurised yogurt with only trace amounts of live lactic acid bacteria).…”

Section: Lactic Acid Bacteria H Hove Et Almentioning

confidence: 99%

“…The best results seem to have been obtained by using Lactobacillus gg (Isolauri et al, 1991, Siitonen et al, 1990, which is a lactobacillus strain initially isolated from healthy humans. The strain was originally selected for its tolerance to acid and bile and the ability to adhere to human small intestinal cells.…”

Section: Lactic Acid Bacteria H Hove Et Almentioning

confidence: 99%

Lactic acid bacteria and the human gastrointestinal tract

1999

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Objective: This review summarises the effects of lactic acid bacteria on lactose malabsorption, bacterialaviral or antibiotic associated diarrhoea, and describes the impact of lactic acid bacteria on cancer and the fermentative products in the colon. Results: Eight studies (including 78 patients) demonstrated that lactase de®cient subjects absorbed lactose in yogurt better than lactose in milk, while two studies (25 patients) did not support this. Two studies (22 patients) showed that unfermented acidophilus milk was absorbed better than milk, while six studies (68 patients) found no signi®cant differences. Addition of lactose hydrolysing enzyme, lactase, to milk improved lactose malabsorption in seven studies (131 lactose malabsorbers), while one study (10 malabsorbers) demonstrated no improvement. Lactic acid bacteria alleviated travellers' diarrhoea in one study (94 individuals) while a study including 756 individuals was borderline statistically signi®cant. One study (50 individuals) did not ®nd an effect of lactic acid bacteria on travellers' diarrhoea. Six studies (404 infants) demonstrated a signi®cant effect of lactic acid bacteria on infant diarrhoea, while one study (40 infants) did not. Lactic acid bacteria moderated antibiotic associated diarrhoea in three studies (66 individuals), while two studies (117 individuals) were insigni®cant. Conclusions: Lactase de®cient subjects bene®t from a better lactose absorption after ingestion of yoghurt compared with milk and from milk added lactase, whereas ingestion of unfermented acidophilus milk does not seem to improve lactose absorption. The majority of studies support that lactic acid bacteria alleviate bacterialaviral induced diarrhoea, especially in infants, while the effect on antibiotic associated diarrhoea is less clear.Experimental studies indicate an effect of lactic bacteria on human cell cancer lines, but clinical evidence is lacking. A`stabilising' effect of lactic acid bacteria on the colonic¯ora has not been documented.

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“…8 Lactobacillus rhamnosus GG is a safe probiotic bacterium, relatively resistant to acid and bile, which adheres in vitro to epithelial cells and intestinal mucus, 9,10 elaborates an antimicrobial substance 11 and transiently colonizes the human intestine. 12,13 Lactobacillus GG has shown promise in the treatment of rotavirus, 14 travellers' 15 and relapsing Clostridium difficile 16 diarrhoea. Although recent studies have provided evidence that beneficial probiotic bacteria can reduce relapses of chronic pouchitis, many questions remain with regard to the dosage required and the selection of the probiotic strain: do we need probiotic cocktails together with antibiotics for a clinical response or is a single probiotic strain effective?…”

Section: Introductionmentioning

confidence: 99%

Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora

Kuisma

Mentula

Järvinen

et al. 2003

Aliment Pharmacol Ther

255

121

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SUMMARYBackground: Preliminary trials of probiotics in preventing recurrent chronic pouchitis have been encouraging. Aim: To investigate the efficacy of Lactobacillus GG supplementation as primary therapy for ileal pouch inflammation, and its effect on the microbial flora. Methods: Twenty patients, with a previous history of pouchitis and endoscopic inflammation, were recruited for a prospective, randomized, double-blind, placebocontrolled trial of Lactobacillus GG supplementation (10 LGG, 10 placebo) in two gelatine capsules [(0.5-1) · 10 10 colony-forming units/capsule] b.d. for 3 months. Quantitative bacterial culture of fresh faecal samples and biopsies taken from the pouch and afferent limb was performed before and after supplementation.

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A Human Lactobacillus Strain (Lactobacillus Gg) Promotes Recovery From Acute Diarrhoea in Children

Cited by 269 publications

References 0 publications

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

Lactic acid bacteria and the human gastrointestinal tract

Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora

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