“…FGF21 levels did not change after cue-reactivity or the priming alcohol drink, but robustly increased after the 2-h alcohol self-administration session and changes in FGF21 levels were trending toward a positive correlation with the amount of alcohol self-administered. 61 Collectively, elevations in endogenous FGF21 following alcohol exposure have been observed across multiple species, including mouse, rat, monkey, and humans.…”