A human homologue to theDrosophila tumour-suppressor gene,l(2)gl, is associated with nonmuscle myosin II heavy chain

Strand, Dennis; Unger, Sylvia; Corvi, R; Hartenstein, Kirsten; Schenkel, Heide; Kalmes, Andreas; Merdes, Gunter; Neuman, Beate; Schwab, Manfred; Mechler, Bernard M.

doi:10.1007/bf02572233

Cited by 50 publications

(65 citation statements)

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“…8 Activation of this kinase leads to specific phosphorylation of p127 and results in the dissociation of myosin-II from p127 without affecting its homomerisation. 8 The interaction between p127 and myosin-II is not only limited to Drosophila but also occurs in human, 9 further supporting the notion that mechanisms similar to those uncovered in Drosophila may also govern the intracellular organisation of human cells.…”

Section: Introductionmentioning

confidence: 64%

The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response

Farkas

Mechler

2000

Cell Death Differ

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Section: Introductionmentioning

confidence: 64%

The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response

Farkas

Mechler

2000

Cell Death Differ

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“…Indeed, Lgl has been shown to bind to the nonmuscle myosin, Myosin II, both in Drosophila and human cells (Strand et al, 1994(Strand et al, , 1995Betschinger et al, 2005). Furthermore, Lgl and Myosin II (Zipper) genetically interact; in lgl mutant neuroblasts, the mislocalization of basal determinants (Miranda) can be rescued by reducing the dose of zipper (Ohshiro et al, 2000;Peng et al, 2000).…”

Section: Scribble/dlg/lgl and Other Polarity Complexesmentioning

confidence: 99%

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

et al. 2008

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The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the vinegar fly Drosophila melanogaster, are currently being actively studied for their potential role in mammalian tumourigenesis. In Drosophila, these tumour suppressors function in a common genetic pathway to regulate apicobasal cell polarity and also play important roles in the control of cell proliferation, survival, differentiation and in cell migration/invasion. The precise mechanism by which Scribble, Dlg and Lgl function is not clear; however, they have been implicated in the regulation of signalling pathways, vesicle trafficking and in the Myosin II-actin cytoskeleton. We review the evidence for the involvement of Scribble, Dlg, and Lgl in cancer, and how the various functions ascribed to these tumour suppressors in Drosophila and mammalian systems may impact on the process of tumourigenesis.

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“…In contrast, Scrib has only one human homolog, hScrib, although related proteins include ERBIN, Lano, and Densin-180 (Santoni et al 2002). Lgl has two human homologs, Llgl1 and Llgl2, and a somewhat related protein called Tomosyn is also present (Tomotsune et al 1993;Strand et al 1995;Fujita et al 1998).…”

Section: Do Vertebrate Ntsg Homologs Play a Role In Cancer?mentioning

confidence: 99%

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

Bilder¹

2004

Genes Dev.

514

510

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Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute to cancer has remained unclear. In Drosophila, mutations in the "neoplastic tumor suppressor genes" (nTSGs) scribble, discs-large, and lethal giant larvae disrupt polarity of epithelia and neuroblasts, and simultaneously induce extensive overproliferation of these cells, which exhibit malignant-like characteristics. Herein I review what is known about the role of the fly nTSGs in controlling cell polarity and cell proliferation. Incorporating data from mammalian studies, I consider how polarity and proliferation can be coupled, and how disruption of polarity could promote cancer.

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A human homologue to theDrosophila tumour-suppressor gene,l(2)gl, is associated with nonmuscle myosin II heavy chain

Cited by 50 publications

References 0 publications

The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response

The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

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