A human combined hepatocellular and cholangiocarcinoma cell line (KMCH-2) that shows the features of hepatocellular carcinoma or cholangiocarcinoma under different growth conditions

Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study

“…The frequency of HBV infection in CHC group was 94.1%, which is higher than the 65% described by Yano et al [21] and the 75.9% described by Kim et al [22]. However, in our study, the median age of patients with CHC was 52 years, which is younger than the median ages of 57 years and 53 years in the above reports [21, 22].…”

“…However, in our study, the median age of patients with CHC was 52 years, which is younger than the median ages of 57 years and 53 years in the above reports [21, 22]. These results strongly suggest that HBV infection is a key etiological mechanism in patients with CHC, and that Chinese CHC patients may be younger at diagnosis compared with patients in the above reports [21, 22]. More interestingly, we identified a concomitant increase in AFP and CA19-9 levels in CHC patients (29.4%, 10/34).…”

“…The frequency of HBV infection in CHC group was 94.1%, which is higher than the 65% described by Yano et al [21] and the 75.9% described by Kim et al [22]. However, in our study, the median age of patients with CHC was 52 years, which is younger than the median ages of 57 years and 53 years in the above reports [21, 22]. These results strongly suggest that HBV infection is a key etiological mechanism in patients with CHC, and that Chinese CHC patients may be younger at diagnosis compared with patients in the above reports [21, 22].…”

“…The cellular origin of CHC is a controversial issue, but three main theories have been proposed: (i) collision (double) tumor of HCC and ICC that coincidentally exist in the same liver; (ii) subsequent differentiation of HCC or ICC into the other component; and (iii) derivation from HPCs, which have the potential to differentiate into both HCC and ICC [21, 23–25]. Despite the above speculations on the cellular origin of CHC, extensive studies on genetic alterations in CHC and comparative analyses between CHC and SHC are lacking.…”

Interferon-αCon1 suppresses proliferation of liver cancer cell lines in vitro and in vivo

“…The cell lines were originally established in our laboratory, and each of the cell lines retains morphological and functional features of original tumor as previously described [13,[30][31][32][33][34][35][36][37].…”