A Human Amnion-Derived Extracellular Matrix-Coated Cell-Free Scaffold for Cartilage Repair:<i>In Vitro</i>and<i>In Vivo</i>Studies

Nogami, Makiko; Kimura, Takeshi; Seki, Shoji; Matsui, Yoshito; Yoshida, Toshiko; Koike-Soko, Chika; Okabe, Motonori; Motomura, Hiroyuki; Gejo, Ryuichi; Nikaido, Toshio

doi:10.1089/ten.tea.2015.0285

Cited by 37 publications

(19 citation statements)

References 41 publications

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“…Wei et al [14] found that human amniotic mesenchymal cells with a collagen scaffold placed in rat articular cartilage defects underwent morphologic changes and led to deposition of type II collagen after induction of chondrogenesis with BMP-2. In another rat model, Nogami et al [15] studied the use of a novel human amniotic mesenchymal cell-derived extracellular matrix (ECM)-coated polyactic-co-glycolic acid (PLGA) scaffold to facilitate cartilage repair. ECM-PLGA scaffolds were placed in osteochondral defects in the trochlear groove of rat knees and were examined histologically.…”

Section: Cartilage and Bone Studiesmentioning

confidence: 99%

Amniotic Product Treatments: Clinical and Basic Science Evidence

Huddleston

Cohn

Haunschild

et al. 2020

Curr Rev Musculoskelet Med

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Purpose of Review Orthobiologics, including amniotic products, have been gaining interest in the past decade for the treatment of various orthopedic conditions including osteoarthritis. However, the use of biologics is varied and is currently available with minimal oversight or regulation. This review will assess the current state of research that utilizes amniotic products both in vitro and in vivo. Recent Findings Amniotic tissue derivatives have been shown to have positive effects in animal models for a variety of conditions. Clinical trials are limited with mixed outcomes, yet some recent studies suggest the rationale for continued investigation. Summary While amniotic products appear promising in numerous animal studies, human clinical trials are still lacking. Future studies are needed to assess whether amniotic products have a role in the treatment of osteoarthritis and other orthopedic pathologies.

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Section: Cartilage and Bone Studiesmentioning

confidence: 99%

Amniotic Product Treatments: Clinical and Basic Science Evidence

Huddleston

Cohn

Haunschild

et al. 2020

Curr Rev Musculoskelet Med

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“…Rat MSCs in vitro, implanted into osteochondral defect in rat knees ECM-coated PLGA Cell-free scaffolds providing an environment for growth of MSCs and facilitating cartilage repair 156 Beck et al…”

Section: Ecm-plgamentioning

confidence: 99%

Reconstruction Strategies of the Ureter and Urinary Diversion Using Tissue Engineering Approaches

Janke

Jonge

Feitz

et al. 2019

Tissue Engineering Part B: Reviews

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Cartilage consists of chondrocytes and a special extracellular matrix (ECM) having unique biochemical, biophysical, and biomechanical properties that play a critical role in the proliferation and differentiation of cells inherent to cartilage functions. Cartilage tissue engineering (CTE) requires recreating these microenvironmental physicochemical conditions to lead to chondrocyte differentiation from stem cells. ECM-derived hybrid scaffolds based on chondroitin sulfate, hyaluronic acid, collagen, and cartilage ECM analogs provide environments conducive to stem cell proliferation. In this review, we describe hybrid scaffolds based on these four cartilage ECM derivatives; we also categorize these scaffolds based on the methods used for their preparation. The use of hybrid scaffolds is increasing in CTE to address the complexity of cartilage tissue. Thus, a comprehensive review on the topic should be a useful guide for future research.Scaffolds fabricated from extracellular matrix (ECM) derivatives are composed of conducive structures for cell attachment, proliferation, and differentiation, but generally do not have proper mechanical properties and load-bearing capacity. In contrast, scaffolds based on synthetic biomaterials demonstrate appropriate mechanical strength, but the absence of desirable biological properties is one of their main disadvantages. To integrate mechanical strength and biological cues, these ECM derivatives can be conjugated with synthetic biomaterials. Hence, hybrid scaffolds comprising both advantages of synthetic polymers and ECM derivatives can be considered a robust vehicle for tissue engineering applications.

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“…Cell‐based and scaffold‐free approaches use various autologous, allogeneic, and xenogeneic cell sources to expand and isolate cell populations to seed a sufficient number of cells . While absorbable and permanent cell‐free constructs are composed of collagen matrix, hyaluronan‐ and polymer‐based materials require cellular recruitment in situ . Each approach shares a common challenge in that it is difficult to grow tissues into their native conformation to replicate the natural structure and function .…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…175 While absorbable and permanent cell-free constructs are composed of collagen matrix, hyaluronan-and polymer-based materials require cellular recruitment in situ. 176 Each approach shares a common challenge in that it is difficult to grow tissues into their native conformation to replicate the natural structure and function. 132 Scaffolds can provide structural support so that cells grow in the correct shape and location.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Current perspectives on biological approaches for osteoarthritis

Whitney

Liebowitz

Bolia

et al. 2017

Annals of the New York Academy of Sciences

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Musculoskeletal injuries that disrupt the structure and function of diarthrodial joints can cause permanent biomechanical alterations and lead to a more severe, chronic condition. Despite advancements that have been made to restore tissue function and delay the need for joint replacement, there are currently no disease-modifying therapies for osteoarthritis (OA). To reduce the risk of OA, innovative preventive medicine approaches have been developed over the last decade to treat the underlying pathology. Several biological approaches are promising treatment modalities for various stages of OA owing to their minimally invasive nature and actively dynamic physiological mechanisms that attenuate tissue degradation and inflammatory responses. Individualized growth factor and cytokine therapies, tissue-engineered biomaterials, and cell-based therapies have revolutionary potential for orthopedic applications; however, the paucity of standardization and categorization of biological components and their counterparts has made it difficult to determine their clinical and biological efficacy. Cell-based therapies and tissue-engineered biologics have become lucrative in sports medicine and orthopedics; nonetheless, there is a continued effort to produce a biological treatment modality tailored to target intra-articular structures that recapitulates tissue function. Advanced development of these biological treatment modalities will potentially optimize tissue healing, regeneration, and joint preservation strategies. Therefore, the purpose of this paper is to review current concepts on several biological treatment approaches for OA.

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A Human Amnion-Derived Extracellular Matrix-Coated Cell-Free Scaffold for Cartilage Repair:In VitroandIn VivoStudies

Abstract: These in vitro and in vivo experiments show that the cell-free scaffold composed of HAM-derived ECM and PLGA provides a favorable growth environment for MSCs and facilitates the cartilage repair process. The ECM-PLGA may become a "ready-made" biomaterial for cartilage repair therapy.

Cited by 37 publications

References 41 publications

Amniotic Product Treatments: Clinical and Basic Science Evidence

Amniotic Product Treatments: Clinical and Basic Science Evidence

Reconstruction Strategies of the Ureter and Urinary Diversion Using Tissue Engineering Approaches

Current perspectives on biological approaches for osteoarthritis

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