A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners

Neira, Víctor; Brito, Bárbara; Agüero, Belén; Berrios, Felipe; Valdés, Valentina; Gutiérrez, Alberto Artamendi; Ariyama, Naomi; Espinoza, Patricio; Retamal, Patricio; Holmes, Edward C.; Gonzalez‐Reiche, Ana S.; Khan, Zenab; Guchte, Adriana van de; Dutta, Jayeeta; Miorin, Lisa; Kehrer, Thomas; Galarce, Nicolás; Almonacid, Leonardo; Lévican, Jorge; Bakel, Harm van; Garcı́a-Sastre, Adolfo; Medina, Rafael

doi:10.1080/22221751.2020.1863132

Cited by 78 publications

(79 citation statements)

References 32 publications

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“…The results of this comprehensive study of SARS-CoV-2 infection in companion and military working dogs sampled before and during the pandemic in areas of active human viral transmission allowed the evaluation of the specificity of the ELISA and AWB assays. The same ELISA test used in our study detected anti-SARS-CoV-2 antibodies in the serum of PCR-positive cats, living in a household in Chile, where a human was infected [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay

et al. 2021

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Dogs are occasionally susceptible to SARS-CoV-2, developing few or no clinical signs. Epidemiological surveillance of SARS-CoV-2 in dogs requires testing to distinguish it from other canine coronaviruses. In the last year, significant advances have been made in the diagnosis of SARS-CoV-2, allowing its surveillance in both human and animal populations. Here, using ELISA and automated western blotting (AWB) assays, we performed a longitudinal study on 809 apparently healthy dogs from different regions of France to investigate anti-SARS-CoV-2 antibodies. There were three main groups: (i) 356 dogs sampled once before the pandemic, (ii) 235 dogs sampled once during the pandemic, and (iii) 218 dogs, including 82 dogs sampled twice (before and during the pandemic), 125 dogs sampled twice during the pandemic and 11 dogs sampled three times (once before and twice during the pandemic). Using ELISA, seroprevalence was significantly higher during the pandemic [5.5% (25/453)] than during the pre-pandemic period [1.1% (5/449)]. Among the 218 dogs sampled twice, at least 8 ELISA-seroconversions were observed. ELISA positive pre-pandemic sera were not confirmed in serial tests by AWB, indicating possible ELISA cross-reactivity, probably with other canine coronaviruses. A significant difference was observed between these two serological tests (Q = 88, p = 0.008). A clear correlation was observed between SARS-CoV-2 seroprevalence in dogs and the incidence of SARS-CoV-2 infection in human population from the same area. AWB could be used as a second line assay to confirm the doubtful and discrepant ELISA results in dogs. Our results confirm the previous experimental models regarding the susceptibility of dogs to SARS-CoV-2, suggesting that viral transmission from and between dogs is weak or absent. However, the new variants with multiple mutations could adapt to dogs; this hypothesis cannot be ruled out in the absence of genomic data on SARS-CoV-2 from dogs.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay

et al. 2021

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“…SARS-CoV-2 infections have been established in a range of animal species, including bats, cats, dogs, ferrets, hamsters, deer mice, otters, white-tailed deer and various nonhuman primates [27][28][29] . Zoonotic transmission from humans to animals has been documented in farmed mink, dogs, and cats [29][30][31][32] as well as in lions and tigers in zoos 33 . Thus, the host range of SARS-CoV-2 extends to a variety of mammalian species, including those maintaining large populations in the wild.…”

Section: Inter-species Spreadmentioning

confidence: 99%

After the pandemic: perspectives on the future trajectory of COVID-19

Telenti

Arvin

Corey

et al. 2021

Nature

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This is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

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“…Four days after the male cat, the two female cats became positive, although asymptomatically. Additionally, one human and one cat showed antibodies against SARS-CoV-2 [ 24 ].…”

Section: Sars-cov-2 Detection In Cats and Their Zoonotic Potentialmentioning

confidence: 99%

Current State of Knowledge about Role of Pets in Zoonotic Transmission of SARS-CoV-2

Dróżdż

Krzyżek

Dudek

et al. 2021

Viruses

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Pets play a crucial role in the development of human feelings, social life, and care. However, in the era of the prevailing global pandemic of COVID-19 disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many questions addressing the routes of the virus spread and transmission to humans are dramatically emerging. Although cases of SARS-CoV-2 infection have been found in pets including dogs, cats, and ferrets, to date there is no strong evidence for pet-to-human transmission or sustained pet-to-pet transmission of SARS-CoV-2. However, an increasing number of studies reporting detection of SARS-CoV-2 in farmed minks raises suspicion of potential viral transmission from these animals to humans. Furthermore, due to the high susceptibility of cats, ferrets, minks and hamsters to COVID-19 infection under natural and/or experimental conditions, these animals have been extensively explored as animal models to study the SARS-CoV-2 pathogenesis and transmission. In this review, we present the latest reports focusing on SARS-CoV-2 detection, isolation, and characterization in pets. Moreover, based on the current literature, we document studies aiming to broaden the knowledge about pathogenicity and transmissibility of SARS-CoV-2, and the development of viral therapeutics, drugs and vaccines. Lastly, considering the high rate of SARS-CoV-2 evolution and replication, we also suggest routes of protection against the virus.

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A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners

Cited by 78 publications

References 32 publications

SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay

SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay

After the pandemic: perspectives on the future trajectory of COVID-19

Current State of Knowledge about Role of Pets in Zoonotic Transmission of SARS-CoV-2

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