A hospital based study of rickettsial diseases evidenced by Weil Felix test in a tertiary care hospital

Udayan, Uttam; Dias, Meena; Machado, Santosh

doi:10.4103/2348-3334.138883

Cited by 5 publications

(3 citation statements)

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“…Fever was the commonest clinical feature in our study followed by rash.A study by Udayan et al showed 61.7% association 15 and a study by Mittal et al showed 51.7% association of rashes with positive WFT a study by Mittal et al showed 5.% association of rashes with positive WFT. 16 Our cases were from both urban and rural areas.…”

Section: Discussionmentioning

confidence: 92%

Prevalence of Rickettsial infections in a tertiary care centre

Akshatha

Vijayalakshmi²

2020

IJMR

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: Rickettsial infections are the most covert re-emerging infections of the present times. They are considered one of the important causes of Pyrexia of Unknown origin (PUO). They are often under diagnosed due to low index of suspicion, nonspecific signs and symptoms and absence of widely available sensitive and specific diagnostic tests. These diseases have a high mortality, which can be averted if diagnosed and treated early. Weil- Felix test is the cheapest and widely used test for diagnosis in India.The present study was undertaken with the objective of evaluating the patients with Febrile illness, for rickettsial infection using Weil- Felix test and study their demographic and clinical profile.: Weil-Felix test was done on serum samples of 120 patients with fever since 7-10 days, from October 2017 to October 2019 and evaluated for Rickettsial infection. Detailed history, signs, symptoms were recorded.: Out the 120 patients, 25 showed a titre of >1:80 in OX2, OX19 and 5 cases showed titre of >1:160 in OX K. The disease was more common in children and in the cooler months. Fever, rash, headache, vomiting and pain abdomen were common symptoms. Most common signs were rash (27 cases) and conjunctival congestion (19 cases).: Though the sensitivity and specificity of Weil-Felix test is low, it is done even today as it is the most convenient and economical test available for the diagnosis of Rickettsial infections. Prevalence of Rickettsial diseases is significant in this region and greater clinical awareness in the differential diagnosis of fevers is required for early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 92%

Prevalence of Rickettsial infections in a tertiary care centre

Akshatha

Vijayalakshmi²

2020

IJMR

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“…Though the test is easy and commonly used in India, the sensitivity is low with high specificity [ 7 ]. The studies ( n = 16) from most of the states of India widely used the WFT as the sole diagnostic tool in RDs ( Table 1 ), and the proportion of non-ST RDs among the studied population ranges from 4.6% to 55% [ 7 , 18 ]. The prevalence of SFG and TG rickettsioses ranges from 0% to 45% and 0 to 6.8% respectively [ 15 , 16 , 18 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…The studies ( n = 16) from most of the states of India widely used the WFT as the sole diagnostic tool in RDs ( Table 1 ), and the proportion of non-ST RDs among the studied population ranges from 4.6% to 55% [ 7 , 18 ]. The prevalence of SFG and TG rickettsioses ranges from 0% to 45% and 0 to 6.8% respectively [ 15 , 16 , 18 , 21 ]. The proportion of samples with undifferentiated rickettsioses with a low positive titre for SFG as well as TG rickettsioses was from 0.5% to 27.6% [ 17 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

A Review of Rickettsial Diseases Other Than Scrub Typhus in India

et al. 2023

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Rickettsial diseases (RD) are widely reported all over the world. Scrub typhus (ST) is a major tropical infection which is well documented all over India. Therefore, the index of suspicion of scrub typhus is high among physicians with regard to patients presenting with acute febrile illness (AFI) and acute undifferentiated febrile illness (AUFI) in India. Rickettsial diseases other than ST (non-ST RDs), which include spotted fever group (SFG) rickettsioses and typhus group (TG) rickettsioses are not uncommon in India, but the index of suspicion is not as high as ST unless there is a history of the presence of fever with rashes and/or recent arthropod bites. This review aims to look into the Indian scenario on the epidemiology of non-ST RDs, especially the SFG and TG rickettsioses based on various investigations, spectrum of clinical presentation, challenges and gaps in knowledge to suspect and diagnose these infections.

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Rickettsial Infections and Q Fever Amongst Febrile Patients in Bhutan

et al. 2018

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There is limited evidence of rickettsial diseases in Bhutan. We explored the contribution of rickettsioses as a cause of undifferentiated febrile illness in patients presenting to 14 Bhutanese hospitals from October 2014 to June 2015. Obvious causes of fever were excluded clinically. Clinico-demographic information and acute blood samples were collected. Samples were tested by immunofluorescence assay (IFA) and qPCR against scrub typhus group (STG), spotted fever group (SFG) and typhus group (TG) rickettsiae, and Q fever (QF). Of the 1044 patients, 539 (51.6%) were female and the mean age was 31.5 years. At least 159 (15.2%) of the patients had evidence of a concurrent rickettsial infection. Of these, 70 (6.7%), 46 (4.4%), 4 (0.4%), and 29 (2.8%) were diagnosed as acute infections with STG, SFG, TG, and QF respectively. Ten (1.0%) patients were seropositive for both SFG and TG. Seven of the 70 STG patients were positive by qPCR. Eschar (p < 0.001), myalgia (p = 0.003), and lymphadenopathy (p = 0.049) were significantly associated with STG, but no specific symptoms were associated with the other infections. Disease incidences were not different between age groups, genders, occupations, and districts, except for students with significantly lower odds of infection with STG (OR = 0.43; 95% CI = 0.20, 0.93; p = 0.031). Rickettsioses were responsible for at least 15% of undifferentiated febrile illnesses in Bhutan, scrub typhus being the commonest. Health authorities should ensure that health services are equipped to manage these infections.

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A hospital based study of rickettsial diseases evidenced by Weil Felix test in a tertiary care hospital

Cited by 5 publications

References 0 publications

Prevalence of Rickettsial infections in a tertiary care centre

Prevalence of Rickettsial infections in a tertiary care centre

A Review of Rickettsial Diseases Other Than Scrub Typhus in India

Rickettsial Infections and Q Fever Amongst Febrile Patients in Bhutan

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