A Hormonal Signaling Pathway Influencing C. elegans Metabolism, Reproductive Development, and Life Span

Gerisch, Birgit; Weitzel, Cindy; Kober-Eisermann, Corinna; Rottiers, Veerle; Antebi, Adam

doi:10.1016/s1534-5807(01)00085-5

Cited by 355 publications

(530 citation statements)

References 55 publications

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“…The D. melanogaster cyp18a1 is also homologous to the Ceanorhabditis elegans (Maupas) gene daf-9, which regulates dauer formation, larval growth, and longevity (Gerisch et al 2001). Dauer formation in C. elegans is a type of dormancy that is similar to insect diapause at both the physiological and molecular level (Sim and Denlinger 2008), and in C. elegans daf-9 loss-of-function mutants form constitutive dauer larvae (Gerisch et al 2001, Jia et al 2002. As illustrated in Fig.…”

Section: Ae Albopictusmentioning

confidence: 99%

Photoperiodic Diapause and the Establishment ofAedes albopictus(Diptera: Culicidae) in North America

Armbruster

2016

J Med Entomol

103

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The invasion and range expansion of Aedes albopictus (Skuse) in North America represents an outstanding opportunity to study processes of invasion, range expansion, and climatic adaptation. Furthermore, knowledge obtained from such research is relevant to developing novel strategies to control this important vector species. Substantial evidence indicates that the photoperiodic diapause response is an important adaptation to climatic variation across the range of Ae. albopictus in North America. Photoperiodic diapause is a key determinant of abundance in both space and time, and the timing of entry into and exit out of diapause strongly affects seasonal population dynamics and thus the potential for arbovirus transmission. Emerging genomic technologies are making it possible to develop high-resolution, genome-wide genetic markers that can be used for genetic mapping of traits relevant to disease transmission and phylogeographic studies to elucidate invasion history. Recent work using next-generation sequencing technologies (e.g., RNA-seq), combined with physiological experiments, has provided extensive insight into the transcriptional basis of the diapause response in Ae. albopictus. Applying this knowledge to identify novel targets for vector control represents an important future challenge. Finally, recent studies have begun to identify traits other than diapause that are affected by photoperiodism. Extending this work to identify additional traits influenced by photoperiod should produce important insights into the seasonal biology of Ae. albopictus.

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Section: Ae Albopictusmentioning

confidence: 99%

Photoperiodic Diapause and the Establishment ofAedes albopictus(Diptera: Culicidae) in North America

Armbruster

2016

J Med Entomol

103

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“…Previous studies by us and other groups showed that CS affects larval development of C. elegans (Gerisch et al, 2001;Jeong et al, 2010). In the present study, we have identified genes likely responsible for the defects of larval development in CS condition using proteomic and RNAi analyses.…”

Section: Discussionmentioning

confidence: 82%

“…Caenorhabditis elegans is a cholesterol auxotroph, which requires exogenously supplied cholesterol for normal growth (Lozano et al, 1984). Cholesterol deprivation or starvation (CS) inhibits growth (Gerisch et al, 2001;Jeong et al, 2010). The effects accumulate with succeeding generations, with CS-mediated developmental defects worsening in the progeny until finally they are arrested at the larval stage (Jeong et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Cholesterol-Responsive Metabolic Proteins Are Required for Larval Development in Caenorhabditis elegans

Kawasaki

Jeong

Yun

et al. 2013

Molecules and Cells

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Caenorhabditis elegans, a cholesterol auxotroph, showed defects in larval development upon cholesterol starvation (CS) in a previous study. To identify cholesterol-responsive proteins likely responsible for the larval arrest upon CS, a comparative proteomic analysis was performed between C. elegans grown in normal medium supplemented with cholesterol (CN) and those grown in medium not supplemented with cholesterol (cholesterol starvation, CS). Our analysis revealed significant change (more than 2.2-fold, p < 0.05) in nine proteins upon CS. Six proteins were down-regulated [CE01270 (EEF-1A.1), CE08852 (SAMS-1), CE11068 (PMT-2), CE09015 (ACDH-1), CE12564 (R07H5.8), and CE09655 (RLA-0)], and three proteins were up-regulated [CE29645 (LEC-1), CE16576 (LEC-5), and CE01431 (NEX-1)]. RNAi phenotypes of two of the down-regulated genes, R07H5.8 (adenosine kinase) and rla-0 (ribosomal protein), in CN were similar to that of larval arrest in CS, and RNAi of a down-regulated gene, R07H5.8, in CS further enhanced the effects of CS, suggesting that downregulation of these genes is likely responsible for the larval arrest in CS. All three up-regulated genes contain putative DAF-16 binding sites and mRNA levels of these three genes were all decreased in daf-16 mutants in CN, suggesting that DAF-16 activates expression of these genes.

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“…Here, it was demonstrated that lifelong reduction of somatic growth is not sufficient to increase the length of life. Instead, these findings support the concepts that integrate reproductive development, energy metabolism, and lifespan, which have already been demonstrated in worms and flies (Gerisch et al ., 2001; Flatt et al ., 2008). Imaginal morphogenesis protein‐late 2 (IMP‐L2), a protein homologous to MAC25 (IGFBP7) that binds to insulin in Drosophila, has also been demonstrated to increase lifespan (Honegger et al ., 2008; Alic et al ., 2011), and it was discussed that IGFBPs may play a role in mammalian aging.…”

Section: Discussionmentioning

confidence: 99%

Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD ‐deficient IGFBP ‐2 variant in female transgenic mice

et al. 2015

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SummaryImpaired growth is often associated with an extension of lifespan. However, the negative correlation between somatic growth and life expectancy is only true within, but not between, species. This can be observed because smaller species have, as a rule, a shorter lifespan than larger species. In insects and worms, reduced reproductive development and increased fat storage are associated with prolonged lifespan. However, in mammals the relationship between the dynamics of reproductive development, fat metabolism, growth rate, and lifespan are less clear. To address this point, female transgenic mice that were overexpressing similar levels of either intact (D‐mice) or mutant insulin‐like growth factor‐binding protein‐2 (IGFBP‐2) lacking the Arg‐Gly‐Asp (RGD) motif (E‐ mice) were investigated. Both lines of transgenic mice exhibited a similar degree of growth impairment (−9% and −10%) in comparison with wild‐type controls (C‐mice). While in D‐mice, sexual maturation was found to be delayed and life expectancy was significantly increased in comparison with C‐mice, these parameters were unaltered in E‐mice in spite of their reduced growth rate. These observations indicate that the RGD‐domain has a major influence on the pleiotropic effects of IGFBP‐2 and suggest that somatic growth and time of sexual maturity or somatic growth and life expectancy are less closely related than thought previously.

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A Hormonal Signaling Pathway Influencing C. elegans Metabolism, Reproductive Development, and Life Span

Cited by 355 publications

References 55 publications

Photoperiodic Diapause and the Establishment ofAedes albopictus(Diptera: Culicidae) in North America

Photoperiodic Diapause and the Establishment ofAedes albopictus(Diptera: Culicidae) in North America

Cholesterol-Responsive Metabolic Proteins Are Required for Larval Development in Caenorhabditis elegans

Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD ‐deficient IGFBP ‐2 variant in female transgenic mice

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