A Hope for Hope: The Role of Hope in Education

Post, Dror

doi:10.47925/2006.271

Cited by 1 publication

(1 citation statement)

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“…As this systematic review takes into account the recently published results of the randomised controlled trial by van Rijn and colleagues (2021), it is currently the most thorough and updated critical analysis of the outcomes of liver transplantation following machine perfusion. Our study shows that HMP is superior to SCS with regards to reducing the risk of EAD, IC, NAS, total biliary complications, major complications and graft loss.…”

Section: Discussionmentioning

confidence: 99%

Liver transplant outcomes after ex vivo machine perfusion: a meta-analysis

Liew

Nasralla

Iype

et al. 2021

British Journal of Surgery

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Background The pressure on liver-transplant programmes has expanded the usage of extended-criteria allografts. Machine perfusion may be better than conventional static cold storage (SCS) in alleviating ischaemia–reperfusion injury in this setting. Recipient outcomes with hypothermic or normothermic machine perfusion were assessed against SCS here. Methods A search in MEDLINE, EMBASE and Scopus was conducted in February 2021. Primary studies investigating ex vivo machine perfusion were assessed for the following outcomes: morbidity, ICU and hospital stay, graft and patient survival rates and relative costs. Meta-analysis was performed to obtain pooled summary measures. Results Thirty-four articles involving 1742 patients were included, of which 20 were used for quantitative synthesis. Odds ratios favoured hypothermic machine perfusion (over SCS) with less early allograft dysfunction, ischaemic cholangiopathy, non-anastomotic strictures and graft loss. Hypothermic machine perfusion was associated with a shorter hospital stay and normothermic machine perfusion with reduced graft injury. Two randomized clinical trials found normothermic machine perfusion reduced major complication risks. Conclusion Machine perfusion assists some outcomes with potential cost savings.

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Section: Discussionmentioning

confidence: 99%