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Catalase Inhibitors with Dual Pro‐Oxidant Effect as New Therapeutic Agents in Castration‐Resistant Prostate Cancer

“…Cellular LIP is defined as a pool of chelatable and redoxactive iron that comprises the entirety of every heterogenous sub-pools of iron, which is not only essential for a wide variety of metabolic processes but also acts as a catalyst in the Haber-Weiss/Fenton reaction, resulting in the generation of ROS. [34][35][36] FPN is the sole known cellular exporter of iron that plays an important role in cellular and systemic iron metabolism. Recently, FPN has been found to be low-expressed in several cancers, such as prostate, [22] acute myeloid leukaemia (AML), breast, ovarian, colorectal, and multiple myeloma, [37][38][39][40][41][42] which may lead to inefficient iron export thus an enrichment of iron ions and a rise of LIP within cancer cells.…”

Ferritin iron as substrate for synthesis of protoheme in intact rat liver mitochondria

“…For this reason the mitochondria are the ultimate destination for a major part of the iron entering the cell [3]. At present little is known about the pathway of iron transport across cytosol and the nature of the compound(s) donating iron to the mitochondria (review [3,4]). In vitro studies have focused particularly on transferrin [5-71, low M, iron-binding compounds [4,8,9] and ferritin [lO,l I] as possible iron donors to the mitochondria.…”