A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

Seal, Snehaa V.; Henry, Mathilde; Pajot, Clémentine; Holuka, Cyrielle; Bailbé, Danielle; Movassat, Jamileh; Darnaudéry, Muriel; Turner, Jonathan D.

doi:10.3389/fimmu.2022.896179

Cited by 2 publications

(2 citation statements)

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“…One of the relevant features of the mice models is that they are immunologically different with some prone to develop Th1 type of immune responses (such as C57bl/6) while others develop Th2 type of immune responses (such as Balb/c) 20 . Similar strain‐dependent effects are also noted in rats as well 37–40 . C57bl/6 and Balb/c are inbred strains of mice which are the most utilized animal models to model obesity and diabetes mellitus, the former more frequently used than the latter.…”

Section: Effect Of Immune Bias In Diet‐induced Obesitymentioning

confidence: 96%

“…20 Similar strain-dependent effects are also noted in rats as well. [37][38][39][40] C57bl/6 and Balb/c are inbred strains of mice which are the most utilized animal models to model obesity and diabetes mellitus, the former more frequently used than the latter. It is tempting to speculate that differential immune response to high-fat feeding may account for the variations that are observed in immunologically different strains of mice such as C57bl/6 (a Th1-biased strain) and Balbc (a Th2-biased strain).…”

Section: Effect Of Immune Bias In Diet-induced Obesitymentioning

confidence: 99%

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High‐fat‐diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis

Pierangeli

Cui²

2023

Chronic Diseases and Translational Medicine

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Obesity and diabetes mellitus are common metabolic diseases prevalent worldwide. Mice are commonly used to study the pathogenesis of these two conditions. Obesity and diabetes mellitus are induced by administering a high‐fat diet in many studies although other diet‐induced models are also used. Several factors may influence the outcome of the studies done to study diet‐induced obesity in mice. The immune system plays a crucial role in the susceptibility of mice to develop obesity and metabolic disease. In this article, the reasons for differences in susceptibility to develop obesity and diabetes mellitus in mice in response to high‐fat‐diet feeding and the influence of immunological bias of the mice strain used in studies are evaluated. Mice strains that induce proinflammatory and Th1‐type immune responses are found to be susceptible to high‐fat‐diet‐induced obesity. A few studies which directly compared the effect of a high‐fat diet on obesity and diabetic phenotype in Th1‐ and Th2‐biased mice strains were briefly analyzed. Based on the observations, it is proposed that the liver and adipose tissue may respond differently to high‐fat‐diet feeding regimens in Th1‐ and Th2‐biased mice strains. For instance, in Th1‐biased mice, adipose tissue fat content was high both in the baseline as well as in response to a high‐fat diet whereas in the liver, it was found to be less. It can be inferred that the immune responses to diet‐induced models may provide insights into the pathogenesis of obesity and diabetes mellitus.

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Section: Effect Of Immune Bias In Diet‐induced Obesitymentioning

confidence: 96%

Section: Effect Of Immune Bias In Diet-induced Obesitymentioning

confidence: 99%

High‐fat‐diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis

Pierangeli

Cui²

2023

Chronic Diseases and Translational Medicine

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Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality

Lezoualc’h

Badimon

Baker

et al. 2022

Cardiovascular Research

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Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery disease and valvular or congenital heart disease, is now recognized as a distinct, multifactorial disease leading to ventricular hypertrophy and abnormal myocardial contractility that correlates with an array of complex molecular and cellular changes. Animal models provide the unique opportunity to investigate mechanistic aspects of diabetic CM, but important caveats exist when extrapolating findings obtained from preclinical models of diabetes to humans. Indeed, animal models do not recapitulate the complexity of environmental factors, most notably the duration of the exposure to insulin resistance that may play a crucial role in the development of diabetic CM. Moreover, most preclinical studies are performed in animals with uncontrolled or poorly controlled diabetes, whereas patients tend to undergo therapeutic intervention. Finally, whilst T2DM prevalence trajectory mainly increases at 40- < 75 years (with a currently alarming increase at younger ages, however), it is a legitimate concern how closely rodent models employing young animals recapitulate the disease developing in old people. The aim of this review is to identify the current limitations of rodent models, and to discuss how future mechanistic and preclinical studies should integrate key confounding factors to better mimic the diabetic CM phenotype.

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A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

Cited by 2 publications

References 68 publications

High‐fat‐diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis

High‐fat‐diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains: A brief overview and hypothesis

Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality

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