A holistic study on potential toxic effects of carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) on zebrafish (Danio rerio) embryos/larvae

Nitrogen-Doped Multiwalled Carbon Nanotubes Enhance Bone Remodeling through Immunomodulatory Functions

“…MWCNTs have been investigated for potential application in cancer diagnosis, in viral enrichment, as vehicles for drug/vaccine delivery, , as immunomodulators, , in viral enrichment, and as biomaterials in tissue engineering. , As nanotechnology rapidly advances, increasing research has been directed toward evaluation of the biological and physiological responses associated with administration of MWCNTs. − The bioreactivity of nanocarbons has been shown to depend on the length, diameter, surface area, dispersibility in solution, functionalization, , and doping properties. , Herein, we provide several lines of evidence showing that N-MWCNTs exhibit good biocompatibility in both human cell lines and mouse models. This demonstrable hypotoxicity is likely due to the nitrogen doping and addition of carboxylic acid functional groups, which is supported by previous reports showing their increased solubility in biocompatible media and diminished toxicity compared with unmodified MWCNTs. , Another reason for low toxicity is likely attributable to the low dosages used in this study, given that the 0.2 μg/mL concentration in vitro and 1 mg/kg bw dosage in vivo were both substantially lower than doses applied in earlier studies. ,, Previous studies have established that exposure dosages strongly affect nanomaterial toxicity and biological activity, , for example, indicated by developmental toxicity to zebrafish embryos/larvae exposed to high dosages of N-MWCNT-COOH . The hypotoxicity and the good biocompatibility ensure broad potential adoption of this material in biomedical and bioengineering applications.…”

“…10,11 Another reason for low toxicity is likely attributable to the low dosages used in this study, given that the 0.2 μg/mL concentration in vitro and 1 mg/kg bw dosage in vivo were both substantially lower than doses applied in earlier studies. 17,36,37 Previous studies have established that exposure dosages strongly affect nanomaterial toxicity and biological activity, 39,40 for example, indicated by developmental toxicity to zebrafish embryos/larvae exposed to high dosages of N-MWCNT-COOH. 39 The hypotoxicity and the good biocompatibility ensure broad potential adoption of this material in biomedical and bioengineering applications.…”

“…17,36,37 Previous studies have established that exposure dosages strongly affect nanomaterial toxicity and biological activity, 39,40 for example, indicated by developmental toxicity to zebrafish embryos/larvae exposed to high dosages of N-MWCNT-COOH. 39 The hypotoxicity and the good biocompatibility ensure broad potential adoption of this material in biomedical and bioengineering applications.…”

Piezoresistive and mechanical Behavior of CNT based polyurethane foam

“…As the picture shows, it is possible to see single nanotubes, using secondary electrons at 10k x magnification. CNT produced by NanoAmor have been well characterized and investigated in previous research works [26][27][28][29]. Later, the same analysis was performed on a neat sample (Figure 2a) to have a reference for further images.…”