A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects — the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action

Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status

“…Together, these events decreased the OSI after three months of atorvastatin administration. The mechanism involved in this phenomenon may be the ability of atorvastatin to reduce the production of reactive oxygen species [34,39,40,45]. On the other hand, atorvastatin may play a role in protecting LDL, and HDL from oxidation by increasing antioxidant activity of the HDL-associated enzyme, PON1 [16,20,31,36,41].…”

Effects of Rosuvastatin on Nitric Oxide–Dependent Function in Aorta and Corpus Cavernosum of Diabetic Mice

“…Statins also attenuate rolling, adherence, and transmigration of leukocytes (45), inhibit superoxide production, and reduce LDL oxidation (46,47) independent of lipid lowering.…”

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

“…It is expressed mainly in the endothelium and its level is increased by angiotensin II or oscillatory shear stress in a NADPH oxidase-dependent manner (McNally et al 2003;Landmesser et al 2007). In experimental atherosclerosis caused by diet induced hypercholesterolemia, excess O 2 •− production was inhibited by oxypurinol, a xanthine oxidase inhibitor (Sumi et al 2001). The mitochondrial electron transport chain generates O 2 •− as a by-product of electron transport during oxidative phosphorylation.…”