A History of the Production and Use of Carbon Tetrachloride, Tetrachloroethylene, Trichloroethylene and 1,1,1-Trichloroethane in the United States: Part 2--Trichloroethylene and 1,1,1-Trichloroethane

Doherty, Richard

doi:10.1006/enfo.2000.0011

Cited by 159 publications

(85 citation statements)

References 24 publications

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“…CCl 4 induces oxidative stress in many settings (Abraham et al, 1999); therefore, it might be expected to contribute to nephrotoxicity. CCl 4 does not occur naturally, it is a clear liquid with sweet smell that can be detected at low levels (Doherty, 2000). Exposure to various compounds including a number of environmental pollutants and drugs can cause cellular damages through metabolic activation of those compounds to a highly reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Effect of melatonin on carbon tetrachloride- induced kidney injury in wistar rats

Adewole¹,

Salako²,

Doherty³

et al. 2010

African Journal of Biomedical Research

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Exposure to carbon tetrachloride (CCl 4 ) induces acute and chronic renal injuries as well as oxidative stress in rats. The aim of this study was to evaluate the effect of exogenous melatonin (MEL) treatment on CCl 4 -induced oxidative stress and nephrotoxicity in rats using histopathological and biochemical parameters. Serum creatinine, blood urea nitrogen (BUN), nitrite and albumin concentrations were measured for the evaluation of renal function. Antioxidant status in the kidney tissue was estimated by determining the activities of superoxide dismustase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and glutathione-S-transferase (GST) as well as thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH

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Section: Introductionmentioning

confidence: 99%

Effect of melatonin on carbon tetrachloride- induced kidney injury in wistar rats

Adewole¹,

Salako²,

Doherty³

et al. 2010

African Journal of Biomedical Research

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“…hlorinated solvents such as tetra-and trichloroethene (PCE/ TCE) have been among the most common subsurface contaminants in the United States for decades (1,2). In situ bioremediation is an effective, economical, and environmentally friendly technology for treating chlorinated solvents (2,3).…”

mentioning

confidence: 99%

Sustainable Growth of Dehalococcoides mccartyi 195 by Corrinoid Salvaging and Remodeling in Defined Lactate-Fermenting Consortia

Men

Seth

et al. 2014

Appl Environ Microbiol

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dCorrinoids are essential cofactors of reductive dehalogenases in Dehalococcoides mccartyi, an important bacterium in bioremediation, yet sequenced D. mccartyi strains do not possess the complete pathway for de novo corrinoid biosynthesis. Pelosinus sp. and Desulfovibrio sp. have been detected in dechlorinating communities enriched from contaminated groundwater without exogenous cobalamin corrinoid. To investigate the corrinoid-related interactions among key members of these communities, we constructed consortia by growing D. mccartyi strain 195 (Dhc195) in cobalamin-free, trichloroethene (TCE)-and lactateamended medium in cocultures with Desulfovibrio vulgaris Hildenborough (DvH) or Pelosinus fermentans R7 (PfR7) and with both in tricultures. Only the triculture exhibited sustainable dechlorination and cell growth when a physiological level of 5,6-dimethylbenzimidazole (DMB), the lower ligand of cobalamin, was provided. In the triculture, DvH provided hydrogen while PfR7 provided corrinoids to Dhc195, and the initiation of dechlorination and Dhc195 cell growth was highly dependent on the growth of PfR7. Corrinoid analysis indicated that Dhc195 imported and remodeled the phenolic corrinoids produced by PfR7 into cobalamin in the presence of DMB. Transcriptomic analyses of Dhc195 showed the induction of the CbiZ-dependent corrinoid-remodeling pathway and BtuFCD corrinoid ABC transporter genes during corrinoid salvaging and remodeling. In contrast, another operon annotated to encode a putative iron/cobalamin ABC transporter (DET1174-DET1176) was induced when cobalamin was exogenously provided. Interestingly, a global upregulation of phage-related genes was observed when PfR7 was present. These findings provide insights into both the gene regulation of corrinoid salvaging and remodeling in Dhc195 when it is grown without exogenous cobalamin and microbe-to-microbe interactions in dechlorinating microbial communities.C hlorinated solvents such as tetra-and trichloroethene (PCE/ TCE) have been among the most common subsurface contaminants in the United States for decades (1, 2). In situ bioremediation is an effective, economical, and environmentally friendly technology for treating chlorinated solvents (2, 3). Dehalococcoides mccartyi is the only known bacterium capable of carrying out respiratory reductive dechlorination of chloroethenes to nontoxic ethene and plays a key role in the bioremediation of contaminated groundwater (4, 5).As cofactors of reductive dehalogenases (RDases), the enzymes responsible for reductive dechlorination, corrinoids (e.g., cobalamin) are essential nutrients for supporting D. mccartyi growth and dechlorination. Genomic analyses of sequenced D. mccartyi strains reveal a lack of complete corrinoid biosynthesis pathways, rendering D. mccartyi incapable of synthesizing corrinoids de novo (6, 7). Exogenous cobalamin (a specific corrinoid also known as vitamin B 12 ) is generally added to grow D. mccartyi in isolation (8). Cobalamin, 5-methylbenzimidazolylcobamide ([5-MeBza]Cba), and 5-methoxyb...

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“…The heavy industrial use of trichloroethene (TCE) as a chlorinated solvent peaked in the early 1970s, when the compound was shown to have both adverse human and adverse environmental effects (12). Consequentially, a seemingly safer alternative, 1,1,1-trichloroethane (1,1,1-TCA), was widely adopted.…”

mentioning

confidence: 99%

A 1,1,1-Trichloroethane-Degrading Anaerobic Mixed Microbial Culture Enhances Biotransformation of Mixtures of Chlorinated Ethenes and Ethanes

Grostern¹,

Edwards

2006

Appl Environ Microbiol

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-TCA) is a common groundwater pollutant as a result of improper disposal and accidental spills. It is often found as a cocontaminant with trichloroethene (TCE) and inhibits some TCEdegrading microorganisms. 1,1,1-TCA removal is therefore required for effective bioremediation of sites contaminated with mixed chlorinated organics. This study characterized MS, a 1,1,1-TCA-degrading, anaerobic, mixed microbial culture derived from a 1,1,1-TCA-contaminated site in the northeastern United States. MS reductively dechlorinated 1,1,1-TCA to 1,1-dichloroethane (1,1-DCA) and then to monochloroethane (CA) but not further. Cloning of bacterial 16S rRNA genes revealed among other organisms the presence of a Dehalobacter sp. and a Desulfovibrio sp., which are both phylogenetically related to known dehalorespiring strains. Monitoring of these populations with species-specific quantitative PCR during degradation of 1,1,1-TCA and 1,1-DCA showed that Dehalobacter proliferated during dechlorination. Dehalobacter growth was dechlorination dependent, whereas Desulfovibrio growth was dechlorination independent. Experiments were also performed to test whether MS could enhance TCE degradation in the presence of inhibiting levels of 1,1,1-TCA. Dechlorination of cis-dichloroethene (cDCE) and vinyl chloride (VC) in KB-1, a chloroethenedegrading culture used for bioaugmentation, was inhibited with 1,1,1-TCA present. When KB-1 and MS were coinoculated, degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE.

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A History of the Production and Use of Carbon Tetrachloride, Tetrachloroethylene, Trichloroethylene and 1,1,1-Trichloroethane in the United States: Part 2--Trichloroethylene and 1,1,1-Trichloroethane

Cited by 159 publications

References 24 publications

Effect of melatonin on carbon tetrachloride- induced kidney injury in wistar rats

Effect of melatonin on carbon tetrachloride- induced kidney injury in wistar rats

Sustainable Growth of Dehalococcoides mccartyi 195 by Corrinoid Salvaging and Remodeling in Defined Lactate-Fermenting Consortia

A 1,1,1-Trichloroethane-Degrading Anaerobic Mixed Microbial Culture Enhances Biotransformation of Mixtures of Chlorinated Ethenes and Ethanes

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