A history of the American Society for Clinical Investigation

Howell, Joel D.

doi:10.1172/jci39091

Cited by 18 publications

(9 citation statements)

References 80 publications

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“…The sultan was deposed by the young Turks in the year 1909, when the ASCI held its inaugural meeting. The founding members based their new society on a revolutionary approach to research that emphasized newer physiological methods, with the hope of bringing sweeping reforms to research, which was analogous to the original young Turks in the Ottoman Empire ( 19 ).…”

Section: The War and Subsequent Jama Controversymentioning

confidence: 99%

A Review of the History of Radioactive Iodine Theranostics: The Origin of Nuclear Ontology

Ehrhardt

Güleç

2020

Mirt

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Studies on the first years of radioactive iodine (RAI) use in thyroid diseases have focused on hyperthyroidism. Saul Hertz’s success with RAI in thyrotoxicosis fueled a seamless transition to Samuel Seidlin’s investigations with RAI in thyroid cancer. These landmark events embody nuclear ontology, a philosophical foundation for the creation and existence of radio-therapeutic principles that continue to influence clinical practices today. Laying this ontological foundation, Dr. Saul Hertz who is the founding director of Massachusetts General Hospital Thyroid Clinic, affiliated with Harvard University created a framework for RAI theranostics with preclinical experiments and clinical cases from 1937 to 1942. The first thyroid cancer treatment with RAI was applied in 1942 by Samuel Seidlin. The sensational effect of the first application was interestingly powerful enough to overshadow scientific data. Seidlin and colleagues assembled a sixteen-patient series showcasing a unique entity: functional thyroid metastases that respond to RAI. Other investigations at the time demonstrated that RAI had little efficacy as a therapeutic agent, mainly because most thyroid tumors do not form colloid, and therefore cannot concentrate RAI. These findings were soon overshadowed by a mainstream article in the October 1949 issue of Life that portrayed RAI as a lifesaving therapy for thyroid cancer. The paradigm was set, and later writings by William H. Beierwaltes and other prominent nuclear medicine physicians established the primary goals and principles of RAI therapy. The developments in theoretical physics and nuclear instrumentation and the scientists who made these developments in the early years contributed greatly to the development of the concept. In the field of nuclear medicine, William H. Beierwaltes has gone down in our history as a clinical researcher with his most important contributions. The classical paradigm that started with him has carried us to today’s molecular theranoistic viewpoint. This paper examines controversial topics in the advent of thyroid theranostics, and applies historical significance to current discussions on the role of RAI in thyroid cancer management. Another paradigm shift is on the horizon as thyroidology enters the age of genomics. The molecular theranostic profiles will soon be incorporated into a dynamic clinical decision-making and management algorithm for thyroid surgery and RAI therapy. From now on, nuclear oncology will gain a new ontological identity with molecular pathology and new theranostic expansions.

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Section: The War and Subsequent Jama Controversymentioning

confidence: 99%

A Review of the History of Radioactive Iodine Theranostics: The Origin of Nuclear Ontology

Ehrhardt

Güleç

2020

Mirt

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“…The Society was first proposed in 1907 by Samuel Meltzer, a relatively new member of the Rockefeller Institute (later becoming Rockefeller University). At the American Medical Association meeting, he proposed the creation of a new organization focused on clinical research; in 1909, Dr. Meltzer provided introductory remarks for the first ASCI meeting, incorporated the previous year with a chief objective for "the advancement of medical science" (1). Two years later would witness the release of the Flexner Report, which transformed medical education from a predominately for-profit enterprise with widely divergent curricula and expertise to a universitybased endeavor with a consistent curriculum and result (2).…”

Section: Asci In Briefmentioning

confidence: 99%

Empowering ASCI’s support of physician-scientists through stronger institutional connections

Marr¹,

Rathmell²,

Hawley³

et al. 2019

Journal of Clinical Investigation

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“…But it is incumbent upon us as individuals and as a society to keep the faith. Samuel Meltzer identified one of the key obligations of society membership as the duty to "further the objectives of the society in the diffusion of the scientific spirit, particularly among his or her students and professional associates" (2). We must continue to nurture and disseminate what Bob Lefkowitz referred to in his 1988 ASCI presidential address as the "spirit of science" (7).…”

Section: Missions For the Futurementioning

confidence: 99%

Leading by example: pastors, mentors, physician-scientists, and the ASCI

Tontonoz¹

2014

J. Clin. Invest.

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A history of the American Society for Clinical Investigation

Cited by 18 publications

References 80 publications

A Review of the History of Radioactive Iodine Theranostics: The Origin of Nuclear Ontology

A Review of the History of Radioactive Iodine Theranostics: The Origin of Nuclear Ontology

Empowering ASCI’s support of physician-scientists through stronger institutional connections

Leading by example: pastors, mentors, physician-scientists, and the ASCI

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