A History of Pivotal Advances in Clinical Research into Bone and Mineral Diseases

Cummings, Steven R.; Eastell, Richard

doi:10.1002/jbmr.3353

Cited by 5 publications

(4 citation statements)

References 105 publications

(132 reference statements)

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“…The results of our study indicate that the trabecular bone pattern could be considered as a potential screening tool for systemic disorders involving changes in bone structure during dental examination. The majority of the included studies assessed osteoporosis, and this fact is consistent with its domination in the published literature (Cummings & Eastell, ). We demonstrated that diseases that highly affect the world's population such as osteoporosis and diabetes may be opportunistically screened in routine dental imaging.…”

Section: Discussionsupporting

confidence: 71%

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

et al. 2018

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The purpose of this systematic review was to evaluate the potential use of dental imaging assessment of trabecular bone structure in the maxillomandibular complex as an adjuvant screening tool to identify systemic disorders. Five electronic databases and grey literature were searched. Studies were included if they investigated subjects with altered trabecular bone determined by dental radiographs. The QUADAS-2 assessed the risk of bias (RoB) among the studies, while the GRADE determined the strength of evidence. A total of 14 studies that included 1,466 individuals were considered eligible for the qualitative analysis. All studies presented an overall low RoB and low concern regarding applicability. Systemic disorders such as osteoporosis, osteogenesis imperfecta, diabetes, and primary hyperparathyroidism, with their respective control groups, were analyzed among the included studies.Osteoporosis was the condition presenting the most significant results, and 72% of the studies detected changes in the maxillomandibular trabecular bone structure.Studies exploring diabetic edentulous patients found less dense trabecular bone pattern (p < 0.05). In summary, periapical and panoramic radiographs, computed tomography, and cone beam computed tomography imaging could be considered useful for the assessment of the mandibular trabecular bone structure of patients affected by osteoporosis and patients with diabetes.

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Section: Discussionsupporting

confidence: 71%

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

et al. 2018

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“…We read with interest the editorial by Cummings and Eastell, A History of Pivotal Advances in Clinical Research in Bone and Mineral Diseases , published in a recent issue of the JBMR .…”

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confidence: 99%

“…In the relevant article, Genant and colleagues were at pains to emphasize the importance of recognizing end‐plate damage as evidence of OVF, but it has proved deceptively simple for readers to see only the diagram which Cummings and Eastell reproduce without noting these constraints. Historically the GSQ method was proposed as an attempt at structured diagnosis in fracture evaluation when such a concept was uncommon.…”

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confidence: 99%

Vertebral Fractures and Morphometric Deformities

Lentle¹,

Oei²,

Goltzman³

et al. 2018

Journal of Bone and Mineral Research

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“…We were pleased to read and are delighted to acknowledge the Editorial of Cummings and Eastell that reviewed the history of pivotal advances in clinical research into bone and mineral disease in connection with the 40th anniversary celebration of the ASBMR. The article provides a succinct review of several key epidemiological, technological, biochemical, and therapeutic advances that, overall, have signaled landmark achievements in our field.…”

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confidence: 99%

Re: A History of Pivotal Advances in Clinical Research Into Bone and Mineral Diseases

Miller

Bilezikian

Lewiecki

et al. 2018

Journal of Bone and Mineral Research

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We were pleased to read and are delighted to acknowledge the Editorial of Cummings and Eastell (1) that reviewed the history of pivotal advances in clinical research into bone and mineral disease in connection with the 40th anniversary celebration of the ASBMR. The article provides a succinct review of several key epidemiological, technological, biochemical, and therapeutic advances that, overall, have signaled landmark achievements in our field.The importance of the combined effects of enhanced study design, analysis, and capability coupled with knowledge of how to apply different research methods to most appropriately address relevant research questions over the past 40 years cannot be overemphasized. (2-7) It was a daunting task to cover everything and, while the Editorial includes many issues, it omits several key points. These include references to key advances, such as the prevalence and importance of fractures in postmenopausal women relative to other diseases, (8) specific delineation of risk factors in postmenopausal women with and without prior fracture, (9-11) age-, sex-, and ethnicity-matched normative reference values for bone mineral density, (12) and the timing, location, and mechanism of fragility fractures among postmenopausal women in many countries. (13)

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A History of Pivotal Advances in Clinical Research into Bone and Mineral Diseases

Cited by 5 publications

References 105 publications

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

Vertebral Fractures and Morphometric Deformities

Re: A History of Pivotal Advances in Clinical Research Into Bone and Mineral Diseases

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