A history of early antiseptics

Dunker, Melvin F.W.

doi:10.1021/ed015p58

Cited by 6 publications

(10 citation statements)

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“…The dimer formation was tested by SDSpolyacrylamide gel electrophoresis (Dunker & Rueckert, 1969) and quantitatively determined by scanning the gels after staining with amido black.…”

Section: Ascorbic Acid Oxidationmentioning

confidence: 99%

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Preparation and Some Properties of a Dimeric Form (S‐s) of Horse Muscle Acylphosphatase

Stefani

Berti

Camici³

et al. 1979

International Journal of Peptide and Protein Research

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The use o f sodium selenite as a catalyst in the presence o f oxygen was a suitable technique to obtain in good yield an interchain S-S dimeric form of horse muscle acylphosphatase. The dimer so obtained possesses kinetic properties very similar to those o f the native enzyme. On the other hand the dimer has shown a generally lower stability in respect o f the thermal inactivation, particularly in the acidic environment, to the lyophilization and to the proteolytic attack. As regards the 8 M urea inactivation, the dimer is not able to completely regain its activity by dilution, showinga behaviour quite different from that of the native enzyme.

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“…The dimer formation was tested by SDSpolyacrylamide gel electrophoresis (Dunker & Rueckert, 1969) and quantitatively determined by scanning the gels after staining with amido black.…”

Section: Ascorbic Acid Oxidationmentioning

confidence: 99%

“…The molecular weights were determined by SDS-polyacrylamide disc-gel electrophoresis according to Dunker (Dunker & Rueckert, 1969) and also by Sephadex G-75 gel filtration according to Andrews (1964).…”

Section: Ascorbic Acid Oxidationmentioning

confidence: 99%

Preparation and Some Properties of a Dimeric Form (S‐s) of Horse Muscle Acylphosphatase

Stefani

Berti

Camici³

et al. 1979

International Journal of Peptide and Protein Research

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“…Chemicals used to clean objects and surfaces in contact with microorganisms are called disinfectants and those applied to living tissues are called antiseptics [1]. The history of the use of chemicals to fight micro-organisms goes back to the time of ancient Egypt [2]. In the 19 th century, disinfection and antisepsis changed with the discovery of chemicals such as chlorine by Carl Scheele; iodine by Bernard Courtois and hydrogen peroxide by Louis Thénard [3].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Assessment of the Toxic Effects of an AKWATON based-disinfectant on Human Tissues

MK¹,

Lesage²,

Gauvin³

et al. 2017

J Antimicrob Agents

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The purpose of this study is to prove the potential safe use of AKWATON as a new antimicrobial product. Many service products are often removed from the market due to their toxic effects on the human body or to their aggressiveness towards the environment. Antimicrobial products such as disinfectants may contain harmful ingredients that can cause disease. Some disinfecting products are corrosive or irritating; others produce strong odors, which in the long run can cause real health problems. AKWATON is a new disinfectant, member of the family of guanidine polymers.Its bactericidal, fungicidal and sporicidal properties have been demonstrated and widely documented. In this study, the toxic effects of AKWATON and of three well known commercial antimicrobial products currently on market, were evaluated and compared on various human tissues including eyes, lung, skin and liver cells. The testing were performed using the TB (Trypan blue) and MTT (3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) methods. Cell-cultures and the different tests done, showed that the AKWATON based-disinfectant was much less toxic, killing many fewer cells than the commercial disinfectants. It spared more than 64% of skin cells; 65% of lung cells; 66% of eye cells and 64% of liver cells while some well-known disinfectants currently marketed killed 100% of cells. This study demonstrated that AKWATON can be used as an odorless, colorless, non-corrosive and harmless disinfectant for hospital, agriculture industry, farming, food service and household facilities or as antiseptic.

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“…10 Most notable is Hippocrates' use of tar ointment, an organic source of carbolic acid, on wounds for the prevention of purulence. 11 More than 2000 years later, carbolic acid would resurface in the treatment of infection after the acceptance of germ theory. 11 In the Middle Ages, specific accounts of the use of topical agents to prevent purulence for head injuries appear in the writings of Abu Bakr Muhammad Ibn Zakariya al-Razi (ad 865-925), a Persian physician whose work was influenced by Hippocrates.…”

mentioning

confidence: 99%

“…11 More than 2000 years later, carbolic acid would resurface in the treatment of infection after the acceptance of germ theory. 11 In the Middle Ages, specific accounts of the use of topical agents to prevent purulence for head injuries appear in the writings of Abu Bakr Muhammad Ibn Zakariya al-Razi (ad 865-925), a Persian physician whose work was influenced by Hippocrates. In a chapter dedicated to neurotrauma in his book Liber Almansoris, al-Razi recommended the use of a concoction consisting of aloe, myrrh, dragon's blood (resin of the Calamus plant species), starch, olibanum, and coral-several of which are compounds that have been found to have antimicrobial properties.…”

mentioning

confidence: 99%

The history of antibiotic irrigation and prophylaxis in operative neurotrauma: perpetuation of military care in civilian settings

Alfawares

Folz

Johnson

et al. 2022

Neurosurgical Focus

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The benefit of antibiotic irrigation for prophylaxis against wound infections, not only for traumatic cranial injuries but also in elective neurosurgical care, has recently been called into question. Several articles have cast doubt on the utility of topical antibiotics, and recently, bacitracin irrigation was made unavailable in some US markets. The pervasive nature of antibiotic irrigation, considering the lack of evidence supporting its use, led the authors to question when and how neurosurgeons started using antibiotic irrigation in cranial neurosurgery. Through a review of historical literature, they highlight the adoption of antibiotic irrigation as it began in battlefield surgical practice, gradually leading to the modern concept of antibiotic prophylaxis in civilian and military care.

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A history of early antiseptics

Cited by 6 publications

References 0 publications

Preparation and Some Properties of a Dimeric Form (S‐s) of Horse Muscle Acylphosphatase

Preparation and Some Properties of a Dimeric Form (S‐s) of Horse Muscle Acylphosphatase

In Vitro Assessment of the Toxic Effects of an AKWATON based-disinfectant on Human Tissues

The history of antibiotic irrigation and prophylaxis in operative neurotrauma: perpetuation of military care in civilian settings

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