A Historical Recount

Moshtaghi, Omid; Sahyouni, Ronald; Lin, Harrison W.; Ghavami, Yaser; Djalilian, Hamid R.

doi:10.1097/mao.0000000000001122

Cited by 19 publications

(9 citation statements)

References 28 publications

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“…Several cross-sectional studies have also reported a high frequency of migraine headaches in MD (Moshtaghi et al 2016) and migraine symptoms during the attacks (Radtke et al 2002;Lopez-Escamez et al 2015). In addition, migraine is associated with inner ear pathologies, including tinnitus, vertigo, and sudden sensorineural hearing loss (Chu et al 2015).…”

Section: Discussionmentioning

confidence: 98%

A Predictive Model of Bilateral Sensorineural Hearing Loss in Meniere Disease Using Clinical Data

et al. 2021

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Objectives: Meniere disease (MD) is defined by a clinical syndrome of recurrent attacks of spontaneous vertigo associated with tinnitus, aural fullness, and sensorineural hearing loss (SNHL). Most patients have unilateral SNHL, but some of them will develop contralateral SNHL during the course of the disease. Several studies have reported a frequency of 2 to 73% SNHL in the second ear, according to the duration of disease and the period of follow-up. We hypothesize that unilateral and bilateral MD are different conditions, the first would initially involve the apical turn of the cochlea, while bilateral MD would affect the entire length of the cochlea. The aim of the study is to search for clinical predictors of bilateral SNHL in MD to build a predictive model of bilateral involvement. Design:A retrospective, longitudinal study including two cohorts with a total of 400 patients with definite MD was carried out. The inception cohort consisted of 150 patients with MD and the validation cohort included 250 cases. All of the cases were diagnosed of unilateral MD according to their hearing loss thresholds. The following variables were assessed as predictors of bilateral SNHL for the two cohorts: sex, age of onset, familiar history of MD, migraine and high-frequency hearing loss (HFHL, defined if hearing threshold >20 dB in two or more consecutive frequencies from 2 to 8 KHz). A descriptive analysis was carried out according to the presence of HFHL in the first audiogram for the main variables. By using multiple logistic regression, we built-up several predictive models for the inception cohort and validated it with the replication cohort and merged dataset.Results: Twenty-three (19.3%) and 78 (41%) of patients with HFHL developed contralateral SNHL during the follow-up, in the inception and validation cohorts, respectively. In the inception cohort, the best predictive model included HFHL in the first audiogram (OR = 6.985, p = 0.063) and the absence of migraine (OR = 0.215, p = 0.144) as clinical predictors for bilateral SNHL [area under the curve (AUC) = 0.641, p = 0.002]. The model was validated in the second cohort (AUC = 0.621, p < 0.001). Finally, we merged both datasets to improve the precision of the model including HFHL in the first audiogram (OR = 3.168, p = 0.001), migraine (OR = 0.482, p = 0.036) and age of onset >35 years old (OR = 2.422, p = 0.006) as clinical predictors (AUC = 0.639, p < 0.001).Conclusions: A predictive model including the age of onset, HFHL in the first audiogram and migraine can help to assess the risk of bilateral SNHL in MD. This model may have significant implications for clinical management of patients with MD.

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Section: Discussionmentioning

confidence: 98%

A Predictive Model of Bilateral Sensorineural Hearing Loss in Meniere Disease Using Clinical Data

et al. 2021

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“…2–5 Even Prosper Meniere mentioned in his original papers that his patients all suffered from migraine. 6 While in the past, Meniere’s disease was thought to be autoimmune 7 or purely peripheral in etiology 8, current evidence points to migraine as the underlying etiology, which manifests with peripheral symptoms via change in the blood flow within the cochlea and vestibule as well as fluid extravasation in the tissues of the inner ear caused by trigeminal nerve activation, the nerve intimately involved with the symptoms of migraine. 3…”

Section: Diagnosis: Migraine-related Meniere’s Syndromementioning

confidence: 99%

Symptom: Vertigo After Labyrinthectomy

Frank

Tawk

Abouzari

et al. 2023

The Hearing Journal

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“…Cochlear migraine consists of migraine and non‐vestibular ear symptoms 11 . Even earlier, in 1966, Atkinson termed MD “migraine in the ear,” characterized by hearing loss secondary to vasospasms in the inner ear 17 . Therefore, MD is theorized to be a manifestation of cochleovestibular migraine as both conditions share a common pathophysiology.…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

A proposed association between subjective nonpulsatile tinnitus and migraine

Lee

Abouzari

Akbarpour

et al. 2022

World j. otorhinolaryngol.-head neck surg.

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Objective: Tinnitus is defined as the perception of sound in the absence of an external source. We propose the hypothesis that migraine can cause exacerbation of tinnitus in some patients.Methods: English literature from PubMed has been reviewed. Results:Studies have reported a high prevalence of cochlear symptoms in patients with migraine headaches and up to 45% of tinnitus patients have been shown to concomitantly suffer from migraine. Both conditions are thought to stem from central nervous system disturbances, involving disruption of the auditory and trigeminal nerve pathways. One proposed mechanism of this association is the modulation of sound sensitivity by trigeminal nerve activation of the auditory cortex during migraine attacks, resulting in tinnitus fluctuation in some patients. Increased brain and inner ear vascular permeability resulting from trigeminal nerve inflammation, can also cause observed headache and auditory symptoms. Tinnitus and migraine also share a number of symptom triggers including stress, sleep disturbances, and dietary factors. These shared features may help explain promising results of migraine therapies for the treatment of tinnitus. Conclusion:Given the complex association between tinnitus and migraine, further investigation is needed to identify the underlying mechanisms and determine the optimal treatment strategies for managing migraine-related tinnitus patients.

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A Historical Recount

Cited by 19 publications

References 28 publications

A Predictive Model of Bilateral Sensorineural Hearing Loss in Meniere Disease Using Clinical Data

A Predictive Model of Bilateral Sensorineural Hearing Loss in Meniere Disease Using Clinical Data

Symptom: Vertigo After Labyrinthectomy

A proposed association between subjective nonpulsatile tinnitus and migraine

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