A Historical-Genetic Reconstruction of Human Extra-Pair Paternity

Larmuseau, Maarten; Berg, Pieter van den; Claerhout, Sofie; Calafell, Francesc; Boattini, Alessio; Gruyters, Leen; Vandenbosch, Michiel; Nivelle, Kelly; Decorte, Ronny; Wenseleers, Tom

doi:10.1016/j.cub.2019.09.075

Cited by 28 publications

(17 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this population, these psychological adaptations are unlikely to explain lineage differences: monogamy was strictly adhered to in this population, with the church forbidding divorce and enforcing punishment for adultery 60 (thus the social environment provided fathers with little reason to doubt paternity). Indeed, historical extra-marital paternity rates in Europe are estimated to have been very low during this period (less than 1.5%) 61,62 . The population parameter of paternity uncertainty is an ancestral, taxonwide parameter, but the impact this might have had on patrilineal grandmaternal behaviour is unknown and may be negligible.…”

Section: Discussionmentioning

confidence: 97%

Offspring fertility and grandchild survival enhanced by maternal grandmothers in a pre-industrial human society

Chapman

Lahdenperä

Pettay

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Help is directed towards kin in many cooperative species, but its nature and intensity can vary by context. Humans are one of few species in which grandmothers invest in grandchildren, and this may have served as an important driver of our unusual life history. But helping behaviour is hardly uniform, and insight into the importance of grandmothering in human evolution depends on understanding the contextual expression of helping benefits. Here, we use an eighteenth-nineteenth century pre-industrial genealogical dataset from Finland to investigate whether maternal or paternal grandmother presence (lineage relative to focal individuals) differentially affects two key fitness outcomes of descendants: fertility and survival. We found grandmother presence shortened spacing between births, particularly at younger mother ages and earlier birth orders. Maternal grandmother presence increased the likelihood of focal grandchild survival, regardless of whether grandmothers had grandchildren only through daughters, sons, or both. In contrast, paternal grandmother presence was not associated with descendants’ fertility or survival. We discuss these results in terms of current hypotheses for lineage differences in helping outcomes.

show abstract

Section: Discussionmentioning

confidence: 97%

Offspring fertility and grandchild survival enhanced by maternal grandmothers in a pre-industrial human society

Chapman

Lahdenperä

Pettay

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…A total of 130 males with their residence in Belgium or the Netherlands (the Low Countries) were selected from previous studies investigating extra-pair paternity rates, haplogroup-specific Y-STR mutation rates, parallel Y-STR evolution and chrY-surname correlation [ 17 , 27 , 30 , 44 , 70 , 71 ]. These samples are further subdivided into five non-related males, 61 genealogical pairs with confirmed biological kinship and four extensive deep-rooted pedigrees enclosing three or four paternally related males.…”

Section: Methodsmentioning

confidence: 99%

CSYseq: The first Y-chromosome sequencing tool typing a large number of Y-SNPs and Y-STRs to unravel worldwide human population genetics

et al. 2021

Self Cite

View full text Add to dashboard Cite

Male-specific Y-chromosome (chrY) polymorphisms are interesting components of the DNA for population genetics. While single nucleotide polymorphisms (Y-SNPs) indicate distant evolutionary ancestry, short tandem repeats (Y-STRs) are able to identify close familial kinships. Detailed chrY analysis provides thus both biogeographical background information as paternal lineage identification. The rapid advancement of high-throughput massive parallel sequencing (MPS) technology in the past decade has revolutionized genetic research. Using MPS, single-base information of both Y-SNPs as Y-STRs can be analyzed in a single assay typing multiple samples at once. In this study, we present the first extensive chrY-specific targeted resequencing panel, the ‘CSYseq’, which simultaneously identifies slow mutating Y-SNPs as evolution markers and rapid mutating Y-STRs as patrilineage markers. The panel was validated by paired-end sequencing of 130 males, distributed over 65 deep-rooted pedigrees covering 1,279 generations. The CSYseq successfully targets 15,611 Y-SNPs including 9,014 phylogenetic informative Y-SNPs to identify 1,443 human evolutionary Y-subhaplogroup lineages worldwide. In addition, the CSYseq properly targets 202 Y-STRs, including 81 slow, 68 moderate, 27 fast and 26 rapid mutating Y-STRs to individualize close paternal relatives. The targeted chrY markers cover a high average number of reads (Y-SNP = 717, Y-STR = 150), easy interpretation, powerful discrimination capacity and chrY specificity. The CSYseq is interesting for research on different time scales: to identify evolutionary ancestry, to find distant family and to discriminate closely related males. Therefore, this panel serves as a unique tool valuable for a wide range of genetic-genealogical applications in interdisciplinary research within evolutionary, population, molecular, medical and forensic genetics.

show abstract

“…Followed by the first empirical demonstrations of their suitability for male relative differentiation (Ballantyne et al, 2012, 2014), many subsequent studies provided increasing evidence on the value of RM Y‐STRs for differentiating related, including closely related, and also unrelated men (Adnan, Ralf, Rakha, Kousouri, & Kayser, 2016; Alghafri, Goodwin, & Hadi, 2013; Boattini et al, 2016, 2019; Lang et al, 2017; Niederstätter, Berger, Kayser, & Parson, 2016; Robino et al, 2015; Salvador et al, 2019; Turrina, Caratti, Ferrian, & De Leo, 2016; Westen et al, 2015; Zgonjanin, Alghafri, Antov et al, 2017). In genetic genealogy too, RM Y‐STRs are advantageous as they provide improved differentiation of unrelated individuals (Ballantyne et al, 2014) and they allow distinguishing closely related from more distantly related males by taking the number of observed mutations into account (Larmuseau et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of novel rapidly mutating Y‐chromosomal short tandem repeat markers

et al. 2020

View full text Add to dashboard Cite

Short tandem repeat polymorphisms on the male‐specific part of the human Y‐chromosome (Y‐STRs) are valuable tools in many areas of human genetics. Although their paternal inheritance and moderate mutation rate (~10−3 mutations per marker per meiosis) allow detecting paternal relationships, they typically fail to separate male relatives. Previously, we identified 13 Y‐STR markers with untypically high mutation rates (>10−2), termed rapidly mutating (RM) Y‐STRs, and showed that they improved male relative differentiation over standard Y‐STRs. By applying a newly developed in silico search approach to the Y‐chromosome reference sequence, we identified 27 novel RM Y‐STR candidates. Genotyping them in 1,616 DNA‐confirmed father–son pairs for mutation rate estimation empirically highlighted 12 novel RM Y‐STRs. Their capacity to differentiate males related by 1, 2, and 3 meioses was 27%, 47%, and 61%, respectively, while for all 25 currently known RM Y‐STRs, it was 44%, 69%, and 83%. Of the 647 Y‐STR mutations observed in total, almost all were single repeat changes, repeat gains, and losses were well balanced; allele length and fathers' age were positively correlated with mutation rate. We expect these new RM Y‐STRs, together with the previously known ones, to significantly improving male relative differentiation in future human genetic applications.

show abstract

A Historical-Genetic Reconstruction of Human Extra-Pair Paternity

Cited by 28 publications

References 51 publications

Offspring fertility and grandchild survival enhanced by maternal grandmothers in a pre-industrial human society

Offspring fertility and grandchild survival enhanced by maternal grandmothers in a pre-industrial human society

CSYseq: The first Y-chromosome sequencing tool typing a large number of Y-SNPs and Y-STRs to unravel worldwide human population genetics

Identification and characterization of novel rapidly mutating Y‐chromosomal short tandem repeat markers

Contact Info

Product

Resources

About