A historic disease still prevalent today

Mitchell, Lorne V; Wilson, Matthew R.; Holmes, Susan

doi:10.1136/bmj.j1013

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…According to case reports of scurvy, in addition to fatigue, anemia, bruising, hematomas, and different types of pain, vitamin C deficiency has been associated with various cardiovascular symptoms [67,68,69,70,71,72,73,74,75,76], dyspnea [64,70,71,72,73,74,75,76,77,78,79,80,81], lower limb edema [13,64,66,70,72,80,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175], infection-type symptoms [66,67,68,73,160,161,165,167,174,175,176,177], bleeding in the gastrointestinal and other regions [76,164,172,175,177,178,…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a comparison between plasma levels of ascorbate and pool sizes showed a very poor correlation… In general, it is fair to say that scurvy appeared when the body pool fell below 300 mg” ([56], p. 441). The most undisputable evidence of scurvy symptoms is that they disappear with vitamin C administration [13,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

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