A histopathological study of the appendix at autopsy and after surgical resection

Andreou, Pantelis; Blain, Stuart; Boulay, C. E. H. du

doi:10.1111/j.1365-2559.1990.tb00763.x

Cited by 47 publications

(33 citation statements)

References 9 publications

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“…Andreou et al . [33] worked on the appendices of 71 male and 30 female post-mortem cases at Southampton General Hospital, Southampton, UK residents. The mean age of the patients was 69.4 years with the majority (80%) being over 60 years of age.…”

Section: Discussionmentioning

confidence: 99%

Negative correlation between age of subjects and length of the appendix in Bangladeshi males

Bakar¹,

Shamim²,

Alam³

et al. 2013

aoms

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IntroductionThe anatomy of the vermiform appendix shows variations in its macroscopic dimensions some of which have potential to influence the clinical aspects of the appendix. Anatomical studies on the appendix using people in Bangladesh as a sample are limited and fall short of producing any standardized anthropometric data. This study is predominantly a cross-sectional observational study which also uses some statistical analysis to understand the relationships amongst variables.Material and methodsFifty-six adult male postmortem appendices and adnexa were examined for macroscopic features. Possible interrelationships among the variables were assessed through statistical analysis. The age of the samples ranged from 18 to 67 years. The most common position of the appendix was retrocolic (53.57%) followed by pelvic (30.35%), postileal (12.5%), and subcaecal (3.5%).ResultsIn most cases (62.5%) the mesoappendix did not reach the tip of the appendix. The appendicular length varied from 6.00 cm to 16.30 cm with mean (± SD) and median value of 10.21 ±2.50 cm and 10.00 cm respectively. The base of the appendix was 1.90 to 3.80 cm away from the ileocaecal junction. The other macroscopic measurements of the appendix were taken at the base, at the midzone and at the tip of the appendix and the mean of the three measurements was considered as the overall value. Thus, the overall external diameter varied between 0.32 cm and 0.83 cm. Assessment of possible correlations amongst different variables revealed a significant negative correlation between the age of the subjects and the length of the appendix.ConclusionsThe data of the present study may provide a baseline along with some previous data in the standardization of the anthropometric information regarding the vermiform appendix of Bangladeshi males.

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Section: Discussionmentioning

confidence: 99%

Negative correlation between age of subjects and length of the appendix in Bangladeshi males

Bakar¹,

Shamim²,

Alam³

et al. 2013

aoms

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“…These challenges to the accepted definition of acute inflammation need to be studied further but are unlikely to replace the time-honoured 'neutrophilic infiltration' yardstick in the foreseeable future for at least two reasons. Firstly, handling of the appendix at laparotomy might explain or contribute to increased cytokine expressions in Wang's cases, and secondly flattening of the appendiceal mucosal surface epithelium often results from hernial obstruction or presence of faecoliths which, while possibly contributing to the subsequent events in acute appendicitis, are not always associated with neutrophilic infiltration [18].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy in Appendicitis: A Histopathological Study

Sathar

Junaid²

2001

Med Princ Pract

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Objective: Although appendicectomy accounts for the highest number of unnecessary surgical procedures, there is little information on the accuracy of the procedure in Kuwait. Therefore, the objective of this study was to determine the accuracy of pre-operative diagnosis of acute appendicitis and the influence of age, gender and surgical personnel on the rate of normal appendicectomy. Materials and Methods: A retrospective histopathological review of specimens involving ‘acute appendicitis’ in the surgical pathology files of the Mubarak Al-Kabeer Hospital, Kuwait in 1982–1986 and 1992–1996 was carried out. The diagnostic accuracy (DA) was defined as the proportion of specimens in which an inflamed appendix was confirmed microscopically and the negative appendicectomy rate (NAR) was the proportion of appendices that were microscopically normal. Results: The DA was 80 and 84% for 1982–1986 and 1992–1996, respectively. There was a marked decline in the number of females in the second period from 42 to 30%. Females, who accounted for 36% of all cases, comprised 61% of normal appendicectomies with the highest NAR in the 20- to 29-year age group (23.7%). The NAR decreased in the second period from 18.4 to 12.4%. Conclusion: The results show that the clinical diagnostic accuracy of appendicitis in Mubarak Al-Kabeer Hospital is consistent with reports from several centres. However, auditing with routine histopathological examination is still necessary to improve clinical evaluation, particularly in females, many of whom are still subjected to the risks of unnecessary laparotomy.

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“…Obstruction can also be the result of lymphoid hyperplasia (Humes, 2007;Walker, 1990), or rarely caecal tumours can obstruct the lumen (Sieren, 2010). A number of authors find little convincing evidence that appendiceal obstruction is the principle cause of acute appendicitis (Carr, 2000;Andreou, 1990). In a small series by Horton (1997) the lumen was empty in 25% of 44 cases and faecoliths were only found in 9% and in the rest, only purulent material or soft faeces were found within the lumen of the appendix.…”

Section: The Pathophysiological Mechanisms Of Acute Appendicitismentioning

confidence: 99%