A Histopathologic Evaluation of Nevocellular Nevi in Pregnancy

Foucar, Elliott; Bentley, Teresa J.; Laube, Douglas W.; Rosai, Uan

doi:10.1097/00006254-198601000-00008

Cited by 23 publications

(37 citation statements)

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“…Hormones may play a role in the pattern of nevi in Turner syndrome. It is known that acquired nevomelanocytic nevi may enlarge during puberty (38) and may increase in number and size, as well as become darker during pregnancy (39). The fact that patients with Turner syndrome have elevated levels of luteinizing hormone and follicle-stimulating hormone during infancy, as well as higher levels at age 10 and 11 years compared with normal girls (40), raises interesting questions about the possible role of hormones in the development and transformation of nevi.…”

Section: Discussionmentioning

confidence: 99%

Melanocytic Nevi in Turner Syndrome

Becker¹,

Jospe

Goldsmith³

1994

Pediatric Dermatology

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One morphologic feature of Turner syndrome is increased numbers of melanocytic nevi; however, little attention has been given to their characterization. The development of a melanoma in one of our patients with Turner syndrome prompted this study. We prospectively examined 10 patients with the disease, confirmed by karyotype. All patients underwent full body skin examination noting the number, size, distribution, and degree of clinical atypia of melanocytic nevi. Representative and unusual lesions were photographed. An average of 115 nevi were seen, with the majority measuring 1 to 5 mm. Most were located on the back and extremities. Clinical atypia was uncommon. Our patients had larger numbers of benign-appearing nevi than the general population. Large numbers of melanocytic nevi is a risk factor for melanoma, suggesting that these patients have an increase in one risk factor. Longitudinal studies are indicated to clarify this issue; nevertheless, we recommend periodic skin examinations and the regular use of sunscreens for individuals with Turner syndrome.

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Section: Discussionmentioning

confidence: 99%

Melanocytic Nevi in Turner Syndrome

Becker¹,

Jospe

Goldsmith³

1994

Pediatric Dermatology

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“…Although the impact of age was not specifically addressed in this study, our experience is these changes are much more prevalent in young adults than in the elderly. The role estrogen plays in the biology and altered histology of breast lesions is intriguing 29,30 but yet unfounded. These features are found on breast lesions of both men and women and are not restricted to the papillomatous variety of pregnancy, 31 for now arguing against the sole impact of the hormonal milieu.…”

Section: Breastmentioning

confidence: 99%

Nevi with site‐related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site

2008

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A subset of melanocytic nevi share features with melanoma and nevi with architectural disorder but are biologically inert and to date do not appear to portend an increased risk for the development of malignancy. These benign nevi with certain atypical histologic features cluster among specific anatomic sites and are thus designated nevi with site-related atypia. We categorize these lesions into four main groups: acral, genital, special site and conjunctival, based on anatomy and relative prevalence of specific atypical histologic features. As the literature and our recognition of these lesions continue to grow, our understanding of their biology has not kept pace.Hosler GA, Moresi JM, Barrett TL. Nevi with site-related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site.

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“…In general, histologic comparison of nevus samples from pregnant women to non-pregnant controls have failed to note a significant difference in cytologic atypia between the study and the control groups (4,(6)(7)(8). However, one series did report a trend towards increased histopathological atypia in nevi from pregnant patients (8). A photographical, clinical and histological analysis of patients with the dysplastic nevus syndrome (DNS) (9) used clinical photographs and histopathology to document both a macroscopic increase in nevi changes and histopathological dysplasia during pregnancy.…”

Section: Introductionmentioning

confidence: 98%

“…However, many of these reports have been criticized because of their reliance on subjective reports from patients regarding nevus size and colour changes (6). In general, histologic comparison of nevus samples from pregnant women to non-pregnant controls have failed to note a significant difference in cytologic atypia between the study and the control groups (4,(6)(7)(8). However, one series did report a trend towards increased histopathological atypia in nevi from pregnant patients (8).…”

Section: Introductionmentioning

confidence: 99%

Estrogen receptor β expression in nevi during pregnancy

Nading

Nanney

Boyd

et al. 2008

Experimental Dermatology

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Estrogen levels increase during pregnancy and clinical evidence has long suggested that melanocytes are estrogen-responsive. We hypothesized that nevi from pregnant patients would exhibit increased expression of estrogen receptor β (ERβ) and thus enhanced potential to respond to altered estrogen levels. Normal, dysplastic and congenital nevi (n = 212) were collected from pregnant and nonpregnant women ranging from 18 to 45 years of age. Immunohistochemical staining was performed on these nevi using antibodies specifically directed against estrogen receptor α (ERα) and ERβ. ERα was not observed in any lesions; thus, ERβ was the predominant estrogen receptor in melanocytic cells from all types of nevi. Enhanced positivity for ERβ in normal nevi during pregnancy was noted, compared with non-pregnant controls including nevocytes residing in both the epidermal and dermal micro-environments (P = 0.005 and P = 0.001 respectively). Nevi with increasingly melanocytic atypia showed increased ERβ in nevocytes nested within the epidermis. No additional increase in ERβ in atypical nevi was observed during pregnancy. For normal and congenital nevi, regardless of pregnancy status, dermally associated nevocytes tended to have greater ERβ immunoreactivity. Significant decreases in ERβ immunoreactivity were observed in congenital nevi from pregnant women compared with normal and dysplastic nevi from pregnant women. Our data suggest that nevi possess the capacity to be estrogen-responsive. Factors such as pregnancy and degree of atypia are associated with enhanced ERβ with the exception of congenital nevi where the melanocytes were unique in their response to pregnancy.

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A Histopathologic Evaluation of Nevocellular Nevi in Pregnancy

Cited by 23 publications

References 0 publications

Melanocytic Nevi in Turner Syndrome

Melanocytic Nevi in Turner Syndrome

Nevi with site‐related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site

Estrogen receptor β expression in nevi during pregnancy

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