A Histomorphometric Comparison of Bio-Oss Alone Versus Bio-Oss and Platelet-Derived Growth Factor for Sinus Augmentation: A Postsurgical Assessment

Froum, Stuart J.; Wallace, Stephen S.; Cho, Sang-Choon; Rosenburg, Edwin; Froum, Scott H; Schoor, Robert; Mascarenhas, Patrick; Tarnow, Dennis P.; Corby, Patricia; Elian, Nicolas; Fickl, Stefan; Ricci, John L.; Hu, Bin; Bromage, Timothy G.; Khouly, Ismael

doi:10.11607/prd.1614

Cited by 38 publications

(71 citation statements)

References 33 publications

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“…Regarding sinus floor augmentation (Supporting Information Table S3), seven studies evaluated rhBMP‐2 (recombinant human morphogenetic protein‐2) in different doses, such as 0.75, 1, and 1.5 mg/ml . One study evaluated a 80:20 ratio of rhBMP‐2/Absorbable collagen sponge mixed with inorganic bovine bone xenograft (Bio‐Oss, Geistlich Pharma, Switzerland).…”

Section: Resultsmentioning

confidence: 99%

“…Only one clinical trial evaluated bovine bone morphogenetic protein (bBMP), or recombinant human osteogenic protein‐1 (rhOP‐1), or recombinant human platelet‐derived growth factor BB (rhPDGF‐BB) for sinus floor augmentation. The controls mainly used were: autogenous bone grafts in four studies, and inorganic bovine bone xenografts in another four clinical trials . The other two clinical trials with sinus floor augmentation used a mineralized cancellous bone allograft.…”

Section: Resultsmentioning

confidence: 99%

“…Other bioactive molecules tested together with bone grafts for sinus floor augmentation were bovine‐extracted osteogenic protein (bBMP) and rhPDGF‐BB . Although some authors have reported using bBMPs successfully in humans, only one study evaluated bBMP in sinus floor augmentation, and demonstrated that the xenogenic bBMP promoted a partial bone formation with the presence of the fibrous tissue in the grafted area.…”

Section: Discussionmentioning

confidence: 99%

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Bioactive treatments in bone grafts for implant‐based rehabilitation: Systematic review and meta‐analysis

Rosa

Silva

et al. 2017

Clin Implant Dent Rel Res

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bioactive treatments in bone grafts for implant‐based rehabilitation: Systematic review and meta‐analysis

Rosa

Silva

et al. 2017

Clin Implant Dent Rel Res

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“…The histological and radiographic findings of few case series showed the regenerative potential of rhPDGF‐BB combined with DBBM for sinus augmentation (Kubota, Sarmiento, Alqahtani, Llobell & Fiorellini, ; Nevins, Garber et al., ), and an RCT showed that this combination could reduce the healing period to 4 months (Froum, Wallace, Cho, Rosenburg, et al., ) (Appendix S6).…”

Section: Resultsmentioning

confidence: 99%

“…rhPDGF‐BB is the only growth factor, beside rhBMP‐2 (and few studies on rhGDF‐5), that has been clinically tested for bone regeneration procedures in the maxillofacial area. Currently, there is limited clinical evidence on its effectiveness for ridge preservation and augmentation (Froum, Wallace, Cho, Rosenburg, et al., b; Kubota et al., ; Nevins, Camelo, Nevins, et al., ; Nevins, Camelo, Schupbach, et al., ) (Appendix S2 and S4). RCTs are needed to clarify whether rhPDGF‐BB combined with different grafting materials can promote post‐extraction ridge preservation, as well as the horizontal and vertical regeneration of alveolar defects.…”

Section: Discussionmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Human platelet‐derived growth factor‐BB (rhPDGF‐BB) with collagen matrix for sinus elevation without using a bone graft

Ghassib,

Saleh,

Wang

2023

Clin Adv Periodontics

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BackgroundThis case report involves a 38‐year‐old male who presented to the clinic after experiencing complications from a tooth extraction, including a dislodged root segment in the sinus, a sinus wall fenestration on the palate, a residual bone height (RBH) of 3 mm, and inadequate healing of the soft tissue. He presented for implant placement.MethodsRecombinant human platelet‐derived growth factor‐BB (rh‐PDGF‐BB) was applied to a wound dressing material and placed in the sinus cavity alongside a 4.8 × 10 mm dental implant (Straumann SP, Straumann, Andover, MA, USA.). As documented in the literature, a graftless sinus lift via a lateral window was performed using a split‐thickness flap technique to elevate the sinus membrane, re‐establish its integrity, and restore its barrier function.ResultsAn 8‐month cone beam computed tomography assessment showed a 6.2 mm vertical bone gain and complete implant coverage.ConclusionThis approach provided a successful alternative to shorten treatment duration and achieve favorable radiographic outcomes during early healing.Key PointsThe use of rhPDGF‐BB and a collagen matrix in a sinus lift procedure emerges as a practical therapeutic option when grafting might lack predictability and notably consume more treatment time, while also achieving the desired bone height when used with a simultaneously placed implant.

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A Histomorphometric Comparison of Bio-Oss Alone Versus Bio-Oss and Platelet-Derived Growth Factor for Sinus Augmentation: A Postsurgical Assessment

Cited by 38 publications

References 33 publications

Bioactive treatments in bone grafts for implant‐based rehabilitation: Systematic review and meta‐analysis

Bioactive treatments in bone grafts for implant‐based rehabilitation: Systematic review and meta‐analysis

The use of bioactive factors to enhance bone regeneration: A narrative review

Human platelet‐derived growth factor‐BB (rhPDGF‐BB) with collagen matrix for sinus elevation without using a bone graft

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