A histological study on the effect of prenatal and postnatal administration of monosodium glutamate on the developing renal cortex of male albino rats

Background: Pregabalin is used for treatment of neuropathic pain, fibromyalgia, and migraine. Objectives: This study was designed to assess the effect of pregabalin on the developing kidney of albino rat's offspring. Material and methods: This study was conducted between September 2019 and January 2020, at Faculty of Medicine for Girls, Al-Azhar University. Twenty pregnant rats were divided into two equal groups: group I (control) group and group II (treated) group which received pregabalin (150 mg/kg/day) from the first day of gestation up to 21 days after delivery. Offsprings were selected to be sacrificed at the 2 nd postnatal day and at the 21 st postnatal day, kidney specimens were prepared for light and electron microscopic examination. Results: Maternal pregabalin administration disrupted the development of the kidney in offsprings with a significant increase in urea and creatinine level. Histological examination of the kidney offsprings at the 2 nd postnatal day revealed irregular thickening of the glomerular basement membrane, fusion, and effacement of podocyte's foot processes and tubulointerstitial injury. Examination of the kidney offsprings at the 21 st postnatal day revealed thickened distorted glomerular basement membrane, broadening, and fusion of the foot processes and vacuolar degeneration of tubules. Conclusion: Maternal pregabalin might disturbed the renal development in the offspring. So, it should be used with caution during pregnancy and lactation.

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Effect of Lead on the Prenatal and Postnatal Development of kidney in Albino Rat and the Possible Protective Effect of Vitamin C (Light and ElectronMicroscopic Study)

Yousef

Assaly

Zahran

2021

Al-Azhar International Medical Journal

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A histological study on the effect of prenatal and postnatal administration of monosodium glutamate on the developing renal cortex of male albino rats

Cited by 3 publications

References 21 publications

Monosodium glutamate in a type 2 diabetes context: A large scoping review

Monosodium glutamate in a type 2 diabetes context: A large scoping review

Effects of Pregabalin on Postnatal Development of The Kidney in Albino Rat’s Offsprings

Effect of Lead on the Prenatal and Postnatal Development of kidney in Albino Rat and the Possible Protective Effect of Vitamin C (Light and ElectronMicroscopic Study)

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