A histological study of tissue response to simulated cleft palate surgery at different ages in Beagle dogs

Wijdeveld, Maarten G.M.M.; Maltha, Jaap C.; Grupping, Ellen M.; Jonge, Jeroen de; Kuijpers-Jagtman, Anne Marie

doi:10.1016/0003-9969(91)90033-q

Cited by 92 publications

(62 citation statements)

References 6 publications

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“…The histological findings in the mucoperiosteum excision group are in agreement with the findings of Wijdeveld et al(1991). The composition of healed tissues was different from normal mucoperiosteum.…”

Section: Discussionsupporting

confidence: 80%

“…Nowadays, surgery is considered one of the major factors causing disturbances in the facial growth of cleft palate patients. This is especially true in the mucoperiosteal denudation of bone followed by wound contraction and formation of scar tissues on the palatal lateral denuded bone area (Kremenak and Searls, 1971;Wijdeveld et al, 1991;Ishikawa et al, 1998;Pigott et al, 2002;Shetye, 2004;Weinzweig et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…In the studies of Wijdeveld et al(1989;1991), palatal surgery according to von Langenbeck technique was simulated in beagle dogs and resulted in inhibition of the growth and development of dento-alveolar structures. They attributed this result to: (1) the initial wounds construction, (2) the firm attachment of scar tissues to the palatine by means of Sharpey's fibers, (3) no elastic fibers demonstrated in the healing tissue, and (4) periodontal fibers being fanned out into the scar tissues.…”

Section: Introductionmentioning

confidence: 99%

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Effects of different types of palatal lateral excisions on growth and development of maxilla and dental arch

Zheng

Shi

et al. 2008

J. Zhejiang Univ. Sci. B

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Abstract:Objective: This study aimed to explore the effects of different types of palatal lateral excisions on the growth and development of the maxilla and dental arch, and to investigate the underlying mechanisms. Methods: A total of 112 3-week-old Sprague-Dawley (SD) male rats were randomly divided into a control and 3 experimental groups: the mucoperiosteal denudation group, the mucosal flap excision group, and the periosteum excision group. In the experimental groups, bilateral mucoperiosteal, mucosal flap and periosteum were excised respectively in the lateral one half of the palate. Four rats in each group were randomly chosen for sacrifice every two weeks. The maxilla was dissected following the excision. The widths of the maxilla and dental arch were measured and the histological phenomena were investigated at different phases. At the same time, 12 animals in each group were sequentially injected with calcein every two weeks. Three animals in each group, whose fluorescent labeling was used, were sacrificed for investigating bone formation at Week 8 following injection. Results: (1) Each experimental group presented the constriction of the maxilla and dental arch. The upper first molars in the experimental groups inclined medially. The mucoperiosteal denudation group showed the largest degree of effect followed by the periosteum excision group. The indices of the mucosal flap excision group, which retained the structures of the periosteum layer, had the most approximate values to the control group; (2) Different histological changes among the experimental groups were detected. The fibers penetrated into the palatal bone as Sharpey's fibers in the mucoperiosteal denudation group. The pattern of bone deposition was the bundle type. Sharpey's fibers were not found in the mucosal flap and periosteum excision groups and the depositions of palatal bone were the lamellar type as those in the control group; (3) The rates of bone deposition in the experimental groups decreased compared with the control group. The rates in different phases were the most approximate values to those of the control group in the mucosal flap excision group, which has the same structure of periosteum as the control group. Conclusion: There were different effects on the growth and development of the maxilla and dental arch in different types of palatal lateral excisions. Periosteum is important for bone formation and deposition pattern. The prevention of Sharpey's fibers forming and attaching to the palatine can effectively avert the following malformation.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of different types of palatal lateral excisions on growth and development of maxilla and dental arch

Zheng

Shi

et al. 2008

J. Zhejiang Univ. Sci. B

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“…16,18,19,24 Kramer et al 25 verified that sagittal maxillary growth slows down immediately after hard palate closure. Kremenak et al 26 and Wijdeveld et al 27 confirmed this relationship with animal studies. Their studies showed that the healing tissue from palate repair led to the restriction of sagittal palatal growth.…”

Section: Discussionmentioning

confidence: 77%

3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life

et al. 2017

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3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life Abstract: This study aimed at monitoring the maxillary growth of children with cleft lip/palate in the first two years of life, and to evaluate the effects of primary surgeries on dental arch dimensions. The sample consisted of the three-dimensional digital models of 25 subjects with unilateral complete cleft lip and palate (UCLP) and 29 subjects with isolated cleft palate (CP). Maxillary arch dimensions were measured at 3 months (before lip repair), 1 year (before palate repair), and at 2 years of age. Student's ttest was used for comparison between the groups. Repeated measures ANOVA followed by Tukey's test was used to compare different treatment phases in the UCLP group. Paired ttest was used to compare different treatment phases in the CP group. P<0.05 was considered statistically significant. Decreased intercanine distance and anterior arch length were observed after lip repair in UCLP. After palate repair, maxillary dimensions increased significantly, except for the intercanine distance in UCLP and the intertuberosity distance in both groups. At the time of palate repair and at two years of age, the maxillary dimensions were very similar in both groups. It can be concluded that the maxillary arches of children with UCLP and CP changed as a result of primary surgery.

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“…Smahel et al 2 and Ishikawa et al 5 described that the lingual inclination of the dentoalveolar process on the cleft side was a result of periosteal denudation of the bone and its scar tissue. Wijdeveld et al, 23 in their histologic studies on beagle dogs, showed that the scar tissue covering denuded bone on lateral sides of the palate were mainly transversally orientated collagenous fibers that lacked blood supply and elastic fibers and had a continuation with the periodontal ligament. This was suggested to be responsible for narrowing of the arch.…”

Section: Discussionmentioning

confidence: 99%

Incisor and molar overjet, arch contraction, and molar relationship in the mixed dentition in repaired complete unilateral cleft lip and palate: A qualitative and quantitative appraisal

Disthaporn

Suri

Ross

et al. 2017

The Angle Orthodontist

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Objective: To compare the mixed dentition incisor and molar overjet, severity of contraction of the dental arch, and the sagittal molar relationship on the cleft side vs the noncleft side in children with repaired complete unilateral cleft of the lip and palate (UCLP). Materials and Methods: Orthodontic records taken prior to orthodontic preparation for alveolar bone grafting were screened to select study casts from patients with nonsyndromic repaired complete UCLP who did not have mandibular skeletal or dental asymmetry. The study sample comprised dental casts from 74 children aged 8.9 6 1 years. Standardized digital photographs were acquired at 1:1 magnification. A coordinate system was developed using digital imageprocessing software (Photoshop CS4 and Adobe Illustrator). Incisor and molar overjet, Angle's classification, and arch contraction were recorded. Descriptive statistics, paired t-tests, and kappa statistics were used to compare the cleft and noncleft sides. Results: A negative overjet of À1 to À5 mm was often present at the incisors, with greater frequency and magnitude on the cleft side. Class II molar relation was more frequent on the cleft side (61.1%) than on the noncleft side (47.2%). Significantly greater contraction of the cleft side deciduous canine and deciduous first molar was noted, while the difference was very minor at the first permanent molar. Conclusions: Cleft side maxillary arch contraction was most severe in the deciduous canine and first deciduous molar region and progressively less severe in the posterior region of the arch. A greater frequency and severity of negative overjet and Class II molar relationship was seen on the cleft side. (Angle Orthod. 2017;87:603-609)

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A histological study of tissue response to simulated cleft palate surgery at different ages in Beagle dogs

Cited by 92 publications

References 6 publications

Effects of different types of palatal lateral excisions on growth and development of maxilla and dental arch

Effects of different types of palatal lateral excisions on growth and development of maxilla and dental arch

3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life

Incisor and molar overjet, arch contraction, and molar relationship in the mixed dentition in repaired complete unilateral cleft lip and palate: A qualitative and quantitative appraisal

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