A Histological Study of the Hepatic and Renal Effects of Subchronic Low Dose Oral Monosodium Glutamate in Swiss Albino Mice

Onaolapo, Adejoke Yetunde

doi:10.9734/bjmmr/2013/2065

Cited by 22 publications

(16 citation statements)

References 19 publications

(14 reference statements)

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“…Periductal fiberous tissue proliferations were also noticed. These results agreed with Wear and Edress (2006), Mohammed (2007), , Eweka et al (2011), Al-Mosaibih (2013) and Onaolapo et al (2013). The bronchioles showed mildest degree of catarrhal bronchiolitis with presence of eosinophilic debris in the lumen and focal areas of leukocytic aggregations.…”

Section: Discussionsupporting

confidence: 87%

“…Other mechanisms for the tubular lesions might involve reactive intermediates or oxidative stress, or both Alden and Frith, (1992) and Ebaid and Tag, (2012). These results agreed with Eweka (2007), Abass and Abd El-Haleem (2011), Eraque (2011), Afeefy et al (2012, Onaolapo et al (2013) and Dixit, et al (2014) who postulated that the degenerative effect of MSG on the cortex and medulla of kidney was due to the direct effect of toxins on cells of kidney which coincided with (Porter, 1994) who reported that one of the possible mechanism for the tubular lesions was the direct toxic effect on the cell function.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Pathological study on the effect of some food additives in male albino rats

AL-Sharkawy

Gab-Allah

El-Mashad

et al. 2017

Benha Veterinary Medical Journal

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A B S T R A C TThe histo and clinicopathological effect of MonoSodium Glutamate (food enhancer) and Sodium MetaBisulfite (food preservatives) on different tissues and organs of male Albino rats were investigated. Eighty male Albino rats (150-180 gm) were divided into 5 groups: control group and 4 groups administrated 30 and 60 mg MSG /kg b.wt; 260 and 520 mg SMB /kg b.wt for 12 weeks per os. Rats were sacrificed at 2, 4, 8 and 12 weeks from beginning the experiment. Significant decrease in Hb concentration, PCV, MCV and MCH; and significant increase in RBCs, leukogram, platelet counts, GPT, GOT, BUN, creatinine and total protein were observed in rats administred 30 and 60 mg MSG /kg b.wt. Histopathologically, mild changes were observed in liver, kidney, heart, stomach and intestine. Multifocally, marked degenerative and necrotic changes were seen in the lining epithelium of the seminiferous tubules and neurons particularly in high doses after 8 and 12 weeks post MSG administration. On the other hand, administration of SMB by a dose 260 and 520 mg/kg b.wt resulted in significant increase in Hb, MCH, MCHC, Platelets, total leukocytic counts, GPT, GOT, albumin, BUN and creatinine values. Microscopically, hyperplasia of the biliary epithelium, lymphoid depletion of white pulpe of the spleen and mild degenerative changes in the lining epithelium of the seminiferous tubules, neurons and cardiac muscle were detected. Moderate changes were seen in the renal tissue characterized by degenerative changes in the endothelial cells of glomeruli and renal tubular epithelium with desquamation of the lining epithelial cells and presence of hyaline casts in the lumen. Multifocally, necrotic gastroenteritis with heavy leukocytic infiltration in the lamina propria of the stomach and intestine. In conclusion, the addition of MSG resulted in marked changes in brain and testes while, SMB lead to marked changes in gastrointestinal tract and brain. These changes are dose and time independent in MSG and dose independent only in SMB.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 85%

Pathological study on the effect of some food additives in male albino rats

AL-Sharkawy

Gab-Allah

El-Mashad

et al. 2017

Benha Veterinary Medical Journal

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“…Similar studies showed that MSG could cause kidney damage. 11,[47][48][49][50][51][52] In the present study, many renal tubules of the rat kidneys showed marked degenerative lesions under the effect of MSG. This is expected since the renal tubules are particularly sensitive to toxic assault.…”

Section: Weight Changementioning

confidence: 74%

Organo-Protective Effect of Moringa oleifera (Moringa) and Camellia sinensis (Green Tea) against Histopathological Damage in Monosodium Glutamate-induced Oxidative-Stressed Rats

Ezeagu¹,

Ayoola²,

Ejiofor³

et al. 2019

Adv Food Technol Nutr Sci Open J

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Cite this articleAyoola MB, Ejiofor NC, Ezeagu IE, Achukwu P. Organo-Protective Effect of Moringa oleifera (Moringa) and Camellia sinensis (Green Tea) against Histopathological Damage in Monosodium Glutamate-induced Oxidative-Stressed Rats. cc BackgroundMoringa oleifera and Camellia sinensis are widely consumed edible plants in parts of South East, Nigeria. It is used as a beverage and also used in the treatment of several ailments by alternative medical practitioners because of its medicinal properties medicinal plant. The histopathological damage repair properties of Moringa oleifera and Camelia sinensis on the brain, liver and kidney organs were investigated on monosodium glutamate (MSG)-induced oxidative-stressed rats. MethodTwenty male Wister rats were divided into five groups of four rats each. Rats were administered with 0.6 mg/g body weight (b.w) dose of MSG solution for 14 days to induce oxidative stress. Control group was given distilled water. A subsequent treatment with MO, GT and their mixture for a period of 28 days was carried out. One group was left untreated. On day 28 of the treatment regime, animals were sacrificed and necessary organs (brain, liver and kidney) harvested. These organs were processed according to paraffin wax embedding technique, stained with haematoxylin and eosin for light microscopy. ResultsThe plant samples both showed in vivo nitric oxide scavenging properties. The plant samples also presented an increased catalase enzyme activity and the lipid profile analyses showed no significant difference at 95% level of probability. Both plants resulted in reversing the damage that occurred in MSG-induced oxidative stressed rats. This was particularly true for both the kidney and liver. ConclusionThe study provides a pharmacological basis for the traditional use of Camellia sinensis and Moringa oleifera extracts in alleviating common medical conditions.

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“…Alterations in the levels of lipid peroxides and antioxidants such as reduce glutathione, catalase and superoxide dismutase were observed in different organs and systems of adult rat during MSG treatment [6,29]. The effects observed in both liver and kidneys could have occurred because these organs are involved in the metabolism of glutamate [30]. MSG has a toxic effect on many body organs by altering ionic permeability of neural membrane and induced persistent depolarization.…”

Section: Discussionmentioning

confidence: 99%

Effect of Nigella Sativa Extract on Inflammatory Cells, Interleukin-10, Interferon-γ and Histological of Kidney in Monosodium Glutamate-Induced Rats

Yousif

Sujuti

Widjajanto

2016

JTLS

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Overconsumption of food additives monosodium glutamate (MSG), a flavour enhancer was unhealthy. Herbal medicine Nigella sativa (NS) has antioxidant properties able to cure the toxic induced by MSG. This study aimed to evaluate the risks of excessive use of MSG and to study the role of NS to inhibit inflammation and renal damage. Treated rats (twenty four male wistar rats) were divided into six group and analyzed by measuring the cells in blood, interleukin-10, interferon-γ serum levels by ELISA method and remove kidneys for histological examination. Histological of kidney for all groups except control, were showed different abnormalities include congestion of some blood vessels, hemorrhage between tubules, widening in the renal tubules, revealed severe dilatation of Bowman's capsule, shrinkage of glomeruli, and huge vacuole area, were observed compared with control. Interleukin-10 was reduced in Groups 2,3,4 and 5, whereas increase in group 6 compared with control. Interferon-γ was increased in groups 2,3,4 and reduced in groups 5,6 compared with control. Eosinophil was increased in groups 2,5 and reduced in groups 3,4 and 6. Basophil was reduced in groups 2, 3 and increased in groups 5 and 6 compared with control. This present study showed that administration of MSG to rats induced many changes effffects on inflammatory cells, cytokines and histological of kidneys. NS has benefit in blood parameters, whereas harmful on kidney at these doses.

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A Histological Study of the Hepatic and Renal Effects of Subchronic Low Dose Oral Monosodium Glutamate in Swiss Albino Mice

Cited by 22 publications

References 19 publications

Pathological study on the effect of some food additives in male albino rats

Pathological study on the effect of some food additives in male albino rats

Organo-Protective Effect of Moringa oleifera (Moringa) and Camellia sinensis (Green Tea) against Histopathological Damage in Monosodium Glutamate-induced Oxidative-Stressed Rats

Effect of Nigella Sativa Extract on Inflammatory Cells, Interleukin-10, Interferon-γ and Histological of Kidney in Monosodium Glutamate-Induced Rats

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