A Histological and Immunohistochemical Study on Chronic Irritant Contact Dermatitis

Non-Invasive Evaluation of the Kinetics of Allergic and Irritant Contact Dermatitis

“…non-invasive evaluation of epidermal hyperproliferation induced by irritants and allergens over time. Our results are compatible with previous immunohistochemical and histological findings by Le et al (1995Le et al ( , 1998 using involucrin and keratin 16 expression, MIB-1 as well as Ki 67 expression to describe differences of ICD and ACD over time.…”

“…Monici et al (1995) have observed an excitation band at 270 nm associated with inflammation. It is not known, however, whether the 278 nm band measured in this study is the same with the 270 nm band reported in the literature (Le et al, 1995(Le et al, , 1998.…”

“…ICD and other skin diseases Ghadially et al, 1996) have previously been associated with changes in epidermal growth, epidermal proliferation as well as differentiation (Le et al, 1996), often resulting in regenerative hyperplasia (Medenica and Rostenberg, 1971). In ICD increased epidermal thickness is a function of parakeratosis and hyperkeratosis (Medenica and Rostenberg, 1971;Le et al, 1995Le et al, , 1998. For ACD, focal parakeratosis, hyperkeratosis, and significantly increased epidermal thickness have previously been described in late phases during follow-up of ACD (Medenica and Rostenberg, 1971), reflecting a delayed hyperproliferative response of subacute ACD reactions.…”

Gene expression profile of AIDS-related Kaposi's sarcoma

“…A strong induction of keratin 16 occurs after physical injury to the human epidermis and is an active part of the epidermal response to wound healing. Keratin 16 is also abundant in many hyperproliferative disorders, including psoriasis, lamellar ichthyosis and chronic irritant dermatitis [46-48]. Expression of epidermal keratins 1, 5, and 10 was lower in KS than in normal skin (Table 6), suggesting that epidermal gene expression is also affected.…”

Serine Proteinase Inhibitors in the Skin: Role in Homeostasis and Disease

“…Psoriasis is the most prominent example [73][74][75], but other disorders such as Behcet's syndrome, Sweet's syndrome, pyoderma gangrenosum, cutaneous allergic vasculitis and acute bacterial infection (cellulitis) not in conditions with dermal lymphocyte infiltration as in chronic prurigo and discoid lupus erythematosus [65]. Elafin is only found in a minority of skins with chronic irritant dermatitis [76] which underlines that an inflammatory skin condition per se is not a prerequisite for elafin expression. It is currently believed that inflammatory mediators such as IL-1β or TNF-α secreted by dermal neutrophils may be involved in overexpression of elafin in keratinocytes; this could protect the epidermis from degradation by dermal neutrophil infiltration.…”