A histological and immunohistochemical study on human penile cavernosal tissue with viewpoints of venogenic erectile dysfunction

Radwan, Dina Mohamed; Kamel, Ehab I.

doi:10.1097/01.ehx.0000395195.49207.98

Cited by 2 publications

(3 citation statements)

References 46 publications

(42 reference statements)

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“…The penile morphology of mammals, which is an integrated part of the complex physiology of male sexual behavioral, varies greatly among the distinct species [4]–[7]. The widely prevalent description of the mammal corpora cavernosa is that they are composed of prominent vascular spaces (also known as sinusoidal, lacunar spaces or cave), separated by incomplete fibromuscular trabeculae, rich in smooth muscle [8], [9]. Each hollow shows incomplete fibromuscular trabeculae, rich in smooth muscle.…”

Section: Introductionmentioning

confidence: 99%

“…The erection is described as sanguineous [2] or as lymphatic and sanguineous in snakes [12], [15]. In birds it is generally considered lymphatic [2], [10].In mammals the erection is a well known blood vascular mechanism [4], [8], [9] Moreover, the hemipenises are functionally independent of one another and only one hemipenis is used during mating, which can last from 3 min to 28 h [22]–[26].…”

Section: Introductionmentioning

confidence: 99%

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The Evolutionary Implications of Hemipenial Morphology of Rattlesnake Crotalus durissus terrificus (Laurent, 1768) (Serpentes: Viperidae: Crotalinae)

et al. 2013

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Most amniotes vertebrates have an intromittent organ to deliver semen. The reptile Sphenodon and most birds lost the ancestral penis and developed a cloaca-cloaca mating. Known as hemipenises, the copulatory organ of Squamata shows unique features between the amniotes intromittent organ. They are the only paired intromittent organs across amniotes and are fully inverted and encapsulated in the tail when not in use. The histology and ultrastructure of the hemipenes of Crotalus durissus rattlesnake is described as the evolutionary implications of the main features discussed. The organization of hemipenis of Crotalus durissus terrificus in two concentric corpora cavernosa is similar to other Squamata but differ markedly from the organization of the penis found in crocodilians, testudinata, birds and mammals. Based on the available data, the penis of the ancestral amniotes was made of connective tissue and the incorporation of smooth muscle in the framework of the sinusoids occurred independently in mammals and Crotalus durissus. The propulsor action of the muscle retractor penis basalis was confirmed and therefore the named should be changed to musculus hemipenis propulsor.The retractor penis magnus found in Squamata has no homology to the retractor penis of mammals, although both are responsible for the retraction of the copulatory organ.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Evolutionary Implications of Hemipenial Morphology of Rattlesnake Crotalus durissus terrificus (Laurent, 1768) (Serpentes: Viperidae: Crotalinae)

et al. 2013

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“…In Masson's trichrome sections of penile cavernosal tissue representing muscular degeneration similar to venogenic ED in human, and collagen fibers were the most abundant component of the trabeculae accompanied with a decrease in smooth muscle area. They appeared as wavy bundles of fibers [19].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of curcumin on microvascular complicationin streptozotocin-induced diabetic rat penis

Khimmaktong¹,

Komolkriengkrai²,

Boonyoung³

et al. 2019

FFHD

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Background: Vascular diseases from diabetes typically result in conditions that interfere with the microvascular functions, such as erectile dysfunction (ED) of the penis. It is unrevealed which morphological changes the microvasculature of the penis may result from the treatment and supplementation of curcumin.Objective: This study aims to determine the effects of curcumin, the active compound of turmeric, on penile microvasculature in experimentally induced diabetic rats.Methods: Rat were divided into three groups, control © and diabetic (DM). Diabetic rats supplemented with curcumin (DMC) (200 mg/kg BW). For induction of a diabetic condition, rats were injected with a single intraperitoneal injection of streptozotocin (60 mg/kg BW). A histological study and vascular corrosion casting along with scanning electron microscopy (SEM) were used to determine a morphological change of microvessels in the penis of rats after 8 weeks of experiments.Results: The histological investigations of penile tissue of DM group revealed thickly lined venous sinuses with smooth but sparse muscle layers. Dorsal arteries (DA) and deep dorsal veins (DV) of the penis were present of narrow lumen and showed thickening of collagen fibers at their wall of tunica media. An increasing thickness of collagen fibers was observed. Vascular corrosion casting revealed critically decreased diameters of DM venous sinus in the penis’ glans, which were observed as shrunken and partially lacking in the distal area of the glans. The diameter of venous sinuses in corpus cavernosum (CC) of DM rats were dilated and the density of venous sinuses was decreased. Interestingly, the signs of vessel restoration and improvement were presented by increasing diameters and recovering with healthy and nourished DA, DV, venous sinus at the area of the glans, and CC of the penis in DMC groups. Conclusion: The results have shown that the effects of curcumin could improve the destruction of the penile microvasculature in induced diabetic rats by STZ. Keywords: Diabetes mellitus, streptozotocin, curcumin, penis, Microvasculature, vascular corrosion cast

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A histological and immunohistochemical study on human penile cavernosal tissue with viewpoints of venogenic erectile dysfunction

Cited by 2 publications

References 46 publications

The Evolutionary Implications of Hemipenial Morphology of Rattlesnake Crotalus durissus terrificus (Laurent, 1768) (Serpentes: Viperidae: Crotalinae)

The Evolutionary Implications of Hemipenial Morphology of Rattlesnake Crotalus durissus terrificus (Laurent, 1768) (Serpentes: Viperidae: Crotalinae)

Ameliorative effects of curcumin on microvascular complicationin streptozotocin-induced diabetic rat penis

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