A histological and histochemical examination of autogenous vein grafts

McCabe, Mary Margaret; Cunningham, Georgina; Wyatt, A P; Rothnie, N. G.; Taylor, G. W.

doi:10.1002/bjs.1800540216

Cited by 60 publications

(11 citation statements)

References 16 publications

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“…The fact that intimal hyperplasia increases the thickness of the vessel wall during arterialization of vein grafts is well-known. 12,13 In this study, medial necrosis of the graft segments was observed. The reason why medial necrosis occurs has not been clarified.…”

Section: Discussionmentioning

confidence: 84%

An absorbable pinned-ring device for microvascular anastomosis of vein grafts: Experimental studies

Muneshige

Ikuta

1999

Microsurgery

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In the rabbit, posterior facial vein segments were grafted to the femoral arteries using either conventional suture technique or a mechanical absorbable pinned-ring device. The purpose of this study was to compare patency rates and anastomotic times for the two different methods. The anastomoses were evaluated macroscopically and using light and scanning electron microscopy. The grafts anastomosed with the absorbable rings exhibited 100% patency, while only 83% of the sutured grafts were patent. The mean anastomotic time using the mechanical pinned-ring device was 18.1 min (range 9.8-30 min). The conventionally sutured anastomoses were completed in a mean time of 60 min (range 50-75 min). The experiment has confirmed that the absorbable pinned-ring device provides a safe and fast way to perform microvascular anastomosis.

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Section: Discussionmentioning

confidence: 84%

An absorbable pinned-ring device for microvascular anastomosis of vein grafts: Experimental studies

Muneshige

Ikuta

1999

Microsurgery

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“…This was aided by previous histological investigations 25,27,29 in which the location of typical intimal hyperplastic cells has been well defined (Fig. 1).…”

Section: Preparation and Study Of Specimensmentioning

confidence: 99%

An ultrastructural study of the intimal hyperplasia in healing microarterial anastomoses

et al. 1998

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The purpose of the study was to investigate the ultrastructure of intimal hyperplastic cells. End-to-end microarterial anastomoses were studied in a rabbit free-tissue-transfer model. There were five experimental groups, with 1, 3, 7, 14, or 28 days follow-up. At sacrifice the anastomoses were tested for patency and then examined by light and electron microscopy. At days 1 and 3 the repaired intima was covered with macrophages and extravasated erythrocytes. At day 7 spindle-shaped fibroblasts with copious rough endoplasmic reticulum were seen. Some of these cells also contained pinocytotic vesicles, filaments with focal densities, and subplasmalemmal attachment sites, the features of smooth muscle cells. At day 14, more cells contained smooth muscle features and these features were also more pronounced. These young myofibroblasts were plumper than adjacent fibroblasts. At day 28 mature myofibroblasts with a full complement of organelles were present. The results, therefore, supported the hypothesis that myofibroblasts are present in the intimal hyperplasia of healing microarterial anastomoses.

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“…MaCabe et al (10) reported that LDH activity in the saphenous vein of greyhounds was intensely positive. In experiments with guinea pigs, Lorenz et al (9) reported that LDH activity in the femoral vein was demonstrated slightly in the intima and the adventitia, but was clearly demonstrated in the media.…”

Section: First Groupmentioning

confidence: 99%

“…MaCabe et al (10) reported that the degree of ICDH and SDH activity was variable in each layer of the venous wall, and that the activity was especially intense in smooth muscle cells.…”

Section: First Groupmentioning

confidence: 99%