A histochemical study of bone marrow hypoplasia in anorexia nervosa

Cornbleet, P. Joanne; Moir, Robert C.; Wolf, Paul L.

doi:10.1007/bf00427118

Cited by 39 publications

(28 citation statements)

References 5 publications

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“…Histological findings are atrophic adipocytes, marrow hypoplasia, and deposition of acid mucopolysaccarides, which are visible on HE stainings as an amorphous ground substance that stains positive by Alcian blue. 2,8 Based on this, the observed AFM likely represents serous fat atrophy, although no macroscopic findings were observed during necropsy. Serous fat atrophy is seen in many different conditions.…”

Section: Discussionmentioning

confidence: 93%

Detection of Porcine Circovirus Type 2 and Viral Replication by In Situ Hybridization in Primary Lymphoid Organs From Naturally and Experimentally Infected Pigs

et al. 2013

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Porcine circovirus type 2 (PCV2) infection is the cause of postweaning multisystemic wasting syndrome (PMWS). It has been speculated whether cell types permissive of replication are found in the primary lymphoid organs and whether infection of these tissues has an important role in the pathogenesis of PMWS. The aim of this study was to determine if primary lymphoid organ cells support viral replication during PCV2 infection. This was done by histopathological examination of thymus and bone marrow from pigs experimentally inoculated with PCV2 (n ¼ 24), mock-infected pigs (n ¼ 12), pigs naturally affected by PMWS (n ¼ 33), and age-matched healthy control animals (n ¼ 29). In situ hybridization (ISH) techniques were used to detect PCV2 nucleic acid irrespective of replicative status (complementary probe, CP) or to detect only the replicative form of the virus (replicative form probe, RFP). PCV2 was not detected in the experimentally PCV2-inoculated pigs or the control animals. Among the PMWSaffected pigs, 19 of 20 (95%) thymuses were positive for PCV2 by CP ISH, and 7 of 19 (37%) of these also supported viral replication. By CP ISH, PCV2 was detected in 16 of 33 (48%) bone marrow samples, and 5 of 16 (31%) of these also supported replication. The 2 ISH probes labeled the same cell types, which were histiocytes in both organs and lymphocytes in thymus. The RFP labeled fewer cells than the CP. Thus, PCV2 nucleic acids and replication were found in bone marrow and thymus of PMWSaffected pigs, but there was no evidence that primary lymphoid organ cells are major supporters of PCV2 replication.

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Section: Discussionmentioning

confidence: 93%

Detection of Porcine Circovirus Type 2 and Viral Replication by In Situ Hybridization in Primary Lymphoid Organs From Naturally and Experimentally Infected Pigs

et al. 2013

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“…In AN, there is a reduction in normal hematopoietic tissue and increase in fat fraction, size, and number of adipocytes in the bone marrow, but the pathophysiology behind the gelatinous bone marrow transformation is unclear [13] . A large retrospective study looked at 80,000 bone marrows and found 155 cases of gelatinous bone marrow transformation (GMT) (fat cell atrophy, focal loss hematopoietic cells, deposition of extracellular gelatinous substances).…”

Section: Discussionmentioning

confidence: 99%

A case of unusual etiology for thrombocytopenia in a young male

Bade

Liu

Mobarek

2015

CRIM

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Anorexia nervosa (AN) has a lifetime prevalence in men of 0.2%-0.3%. AN has been implicated in hematologic abnormalities including anemia, leukopenia, and less frequently thrombocytopenia. Only about 5% of patients with AN related cytopenias will have thrombocytopenia.Herein we discuss a patient with AN who initially presented with fatigue and thrombocytopenia (platelet count nadir of 49,000/µL). His initial workup was negative; however a bone marrow biopsy revealed profound hypocellularity of ten percent. AN related marrow suppression can occur via gelatinous bone marrow transformation as was the situation with our patient. His peripheral cell counts improved with improvement in his nutritional status. This is one of the few case reports of male anorexia leading to profound hypocellularity of the bone marrow.

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“…The marrow gelatinous transformation has been referred to as starvation marrow. Most of the cases of severe nutritional deficiency were seen with anorexia nervosa [1,3,5]. A depletion of protein or fat appears to account for many of the reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…Gelatinous transformation has been reported to occur in a variety of chronic disorders, including prolonged starvation, anorexia nervosa, malabsorption, malignant disease, and HIV infection [1,2]. The gelatinous substances deposited in the marrow had been demonstrated histochemically as hyaluronic acid mucopolysaccharides [3,4]. However, the pathogenic mechanism of the marrow lesion remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Gelatinous transformation of bone marrow from a starch‐free diet

2001

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Gelatinous marrow transformation is characterized by marrow hypoplasia, fat atrophy, and gelatinous material deposition, and usually develops as a hematologic complication of chronic wasting disorders. Most of the cases associated with severe nutritional deficiency were seen in anorexia nervosa due to a depletion of protein or fat. This report describes a case of gelatinous transformation attributed to a specific restriction of carbohydrates in diet. The hematologic deficiency was eventually recovered after the patient resumed a regular starch-containing diet. This brief report illustrates the potential side effect of the compulsive dietary behavior on the hematologic system. Am. J. Hematol. 68:58-59, 2001.

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A histochemical study of bone marrow hypoplasia in anorexia nervosa

Cited by 39 publications

References 5 publications

Detection of Porcine Circovirus Type 2 and Viral Replication by In Situ Hybridization in Primary Lymphoid Organs From Naturally and Experimentally Infected Pigs

Detection of Porcine Circovirus Type 2 and Viral Replication by In Situ Hybridization in Primary Lymphoid Organs From Naturally and Experimentally Infected Pigs

A case of unusual etiology for thrombocytopenia in a young male

Gelatinous transformation of bone marrow from a starch‐free diet

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