A histochemical and electron‐microscope study of submucous fibrosis of the palate

Sirsat, Satyavati M.; Khanolkar, V. R.

doi:10.1002/path.1700730214

Cited by 27 publications

(23 citation statements)

References 5 publications

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“…Moreover, they were more frequently pointed in tobacco users (Table III). Deep invagination of epithelium into subjacent lamina propria in cases of submucous fibrosis has been described by Sirsat and Khanolkar (1962). Liquefaction in basal cell layer was not observed in our cases as reported by Sharan (1959) andPindborg et al (1965).…”

Section: Commentssupporting

confidence: 80%

“…Sirsat and Khanolkar (1957), Sharan (1959, and Rao (1962) have described marked increase in dense collagen in the sub-epithelial tissue. Sirsat andKhanolkar (1957 and1962) and Sharan (1959) have also described hyalinization of the connective tissue. The changes in connective tissue have been interpreted as fibrinoid degeneration by Sharan (1959) and elastotic degeneration by Sirsat and Khanolkar (1962).…”

Section: Commentsmentioning

confidence: 96%

“…Sirsat andKhanolkar (1957 and1962) and Sharan (1959) have also described hyalinization of the connective tissue. The changes in connective tissue have been interpreted as fibrinoid degeneration by Sharan (1959) and elastotic degeneration by Sirsat and Khanolkar (1962). Rao (1962), on the other hand, did not find elastotic or fibrinoid degeneration.…”

Section: Commentsmentioning

confidence: 99%

“…Sirsat andKhanolkar (1957, 1962) also described a thickened epithelium with deep invagination into subjacent lamina propria. Sharan (1959) described hypertrophy with occasional areas of atrophy.…”

Section: Commentsmentioning

confidence: 99%

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Submucous fibrosis of the oral cavity. Histomorphological studies.

Wahi¹,

Luthra²,

Kapur³

1966

Br J Cancer

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Section: Commentssupporting

confidence: 80%

Section: Commentsmentioning

confidence: 96%

Section: Commentsmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

See 2 more Smart Citations

Submucous fibrosis of the oral cavity. Histomorphological studies.

Wahi¹,

Luthra²,

Kapur³

1966

Br J Cancer

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“…15 Shanta and Krishnamurthi, 1963). The lack of protein in the diet produces many tissue changes in the oral cavity such as thinning of the mucosal epithelium (Stahl, Sandler and Cahn, 1955;Unakar, 1960) and retarded wound healing (Udupa, Woessner and Dunphy, 1956 Clark, 1953;Pirani et al, 1950;1951;Sirsat and Khanolkar, 1960;Ketkar and Sirsat, 1966). There was originally some confusion as to whether DOCA was responsible for the production of inflammation per se.…”

mentioning

confidence: 99%

Histological changes in the oral mucosa of the wistar rat treated with commercial lime (calcium hydroxide)--an optical and submicroscopic study

Sirsat¹,

Kandarkar²

1968

Br J Cancer

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THE high incidence of oral cancer in different population groups in many south-east Asian nations has been stressed repeatedly in early and recent reports (Orr, 1933; Balendra, 1949; Cooray, 1944; Khanolkar, 1959; Muir, 1962; Pindborg, 1965). In India, and elsewhere, epidemiological and biological investigations have been done, or are in progress, on any possible correlation between the habitual use of the betel chew or " pan " and oral cancer. The involvement of the main constituents of " pan "-betel leaf (Piper betel), betel nut (Areca catechu), tobacco (Nicotiana tabacum), slaked shell or stone lime (slaked calcium hydroxide) and catechu (Acacia catechu) have also been considered individually or in combination (Mody and Ranadive, 1959;Muir and Kirk, 1960;Dunham, Muir and Hamner, 1966). The role of lime appears rather controversial, though some reports do suggest its correlation with the occurrence of oral cancer. It was therefore considered worthwhile to study the effects of slaked commercial lime on the oral mucosa of laboratory animals. The main aims of the study were to evaluate the part played by lime in the causation of oral malignancy or of oral conditions considered to be precancerous and the trauma it caused to epithelial and subepithelial tissue. This paper reports the histological changes produced on short term and prolonged application of lime to the oral mucosa of normal, diet conditioned and hormone treated Wistar rats. MATERIAL AND METHODSOne hundred and thirty-nine weanling Wistar rats (66 male and 73 female) were divided into four experimental groups as follows:Group I-36 animals on standard laboratory diet (wheat 66%; cracked lentils 15%; pea nut 5%; fish meal 7 %, shark liver oil 1%, sesame oil 1%).Group 11-35 animals on a protein deficient diet (milled rice 1000 g.; NaCl 10 g.; vegetable oil 50 ml.; cod liver oil 20 ml.; B-complex tablets (100 mg.) 3 tablets).Group llI-36 animals on a vitamin B deficient diet (Sucrose 34.5%; corn starch 34.0%; vegetable oil (vitamin A + D -700 Units) 6-7%; vitamin free casein 20%; NaCl 1.0%; CaCO3 0.5%).Group IV-32 animals on standard laboratory diet, pretreated locally with deoxycorticosterone acetate (DOCA). The hormone (Decortone-Cipla Ltd., Bombay) was injected on the palate biweekly in a dose of 1 mg. per injection.

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Some observations on oral and pharyngeal carcinomas in the state of bombay

Paymaster

1962

Cancer

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A histochemical and electron‐microscope study of submucous fibrosis of the palate

Cited by 27 publications

References 5 publications

Submucous fibrosis of the oral cavity. Histomorphological studies.

Submucous fibrosis of the oral cavity. Histomorphological studies.

Histological changes in the oral mucosa of the wistar rat treated with commercial lime (calcium hydroxide)--an optical and submicroscopic study

Some observations on oral and pharyngeal carcinomas in the state of bombay

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