Abstract:A hydrophilic interaction liquid chromatography (HILIC) method coupled with a refractive index (RI) detector was developed for the determination of hydroxypropyl-β-cyclodextrin (HP-β-CD). This HILIC method used simple acetonitrile/water (80/20, v/v) as the mobile phase to provide sufficient retention for HP-β-CD. The method was found to be specific without interference from the other constituents in pharmaceutics. The method was also validated for linearity and accuracy of the drug sample. The effects of vario… Show more
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