2020
DOI: 10.1016/j.jhazmat.2020.122902
|View full text |Cite
|
Sign up to set email alerts
|

A highly substituted and fluorescent aromatic-fused imidazole derivative that shows enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
8
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 18 publications
(8 citation statements)
references
References 44 publications
0
8
0
Order By: Relevance
“…They are known to inhibit the synthesis of ergosterol, the main sterol of fungal membranes, as well as other important components [26,27]. Imidazoles are currently the focus of numerous medicinal chemistry efforts and many derivatives have shown potent antibacterial and anti-biofilm activity [28][29][30][31]. Therefore, it is not surprising that they were also identified as positive hits in our study.…”
Section: Hit-to-lead Identification Processmentioning
confidence: 58%
“…They are known to inhibit the synthesis of ergosterol, the main sterol of fungal membranes, as well as other important components [26,27]. Imidazoles are currently the focus of numerous medicinal chemistry efforts and many derivatives have shown potent antibacterial and anti-biofilm activity [28][29][30][31]. Therefore, it is not surprising that they were also identified as positive hits in our study.…”
Section: Hit-to-lead Identification Processmentioning
confidence: 58%
“…Interestingly, A. mali FL18 became resistant to all the antibiotics tested, except to chloramphenicol and tetracycline. The MIC values determined against ampicillin, erythromycin, kanamycin, streptomycin, and vancomycin were comparable to those of other antibiotic-resistant bacteria, as well as those relative to bacitracin (700 µg/ml) and ciprofloxacin (up to 1 mg/ml) (D'Aimmo et al, 2007;Minarini et al, 2012;Bulut et al, 2020). Besides the putative gene coding for BcrC and possibly responsible for bacitracin resistance (see above), it can be hypothesized that the expression of several multidrug-efflux transporters (Table 5) is responsible for the resistance to the other tested antibiotics.…”
Section: Antibiotic Susceptibility In a Mali Fl18mentioning
confidence: 58%
“…Particularly, the PVDF‐2 membrane performed much better against E. coli and S. aureus strains. The multiple pathways relating to zinc and imidazole involvement in antibacterial activity have been reported 57,58 . The zinc and imidazole could bind to the cell membrane of bacteria and possibly destroy the strain's arrangement.…”
Section: Resultsmentioning
confidence: 99%