A highly sensitive microfluidics system for multiplexed surface-enhanced Raman scattering (SERS) detection based on Ag nanodot arrays

Chen, Gang; Wang, Yuyang; Wang, Hailong; Cong, Ming; Chen, Lei; Yang, Ye; Geng, Yijia; Li, Haibo; Xu, Shuping; Xu, Weiqing

doi:10.1039/c4ra09251a

Cited by 39 publications

(25 citation statements)

References 31 publications

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“…Each SERS spectrum shows four major peaks at Δ v = 485, 708, 1073, and 1586 cm −1 , respectively. The peaks at Δ v = 485 and 708 cm −1 correspond to the symmetric SiOSi and SiC stretching of PDMS, while the peaks at Δ v = 1073 and 1586 cm −1 correspond to v 12 and v 8a aromatic ring vibrations of MBA . The PDMS Raman peak intensities increase with x c while the MBA SERS intensities decrease with x c .…”

Section: Resultsmentioning

confidence: 98%

A Flexible Strategy to Fabricate Gradient Plasmonic Nanostructures

Larson

Bradley

et al. 2018

Adv Materials Inter

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geometric parameters were fabricated to provide varied reflection spectra and surface enhanced Raman scattering (SERS) signals. [11] These types of plasmonic substrates can be applied as integrated platforms in optical biosensing, [12] telecommunication, [13] surface-enhanced spectroscopy, [14] and light harvesting. [15] Material gradients are also a valuable material research tool that allows highthroughput and cost-effective screening material properties in a minimum amount of time. To speed up materials discovery, an artificial library containing gradients of the material parameters of interest (morphology, composition, surface property, etc.) under similar condition is experimentally created, [16] and rapid, local, and automated measurements are performed to establish a material parameter-property relationship. [1,17] Such a methodology is generally faster and less expensive than traditional (e.g., "one material at a time") approach. Since all characterizations are carried out on the same library samples with the same measurement tools over a short time period, most systematic errors are eliminated, thus generating a comprehensive and reliable data set. In particular, plasmonic library based on ordered and well-defined noble metal gradient nanostructures has been extensively studied. Plasmonics, known as coherent oscillations of conduction electrons on a metal surface excited by electromagnetic radiation at a metal-dielectric interface, constitute one of the most important building blocks of contemporary nanoscience and nanotechnology. [18] Plasmonic properties are strongly dependent on the size, shape, orientation, and interspacing of the nanostructures. [19] The study of geometric-dependent (or compositional) optical properties and the optimization of nanofabrication protocols can be greatly facilitated by establishing plasmonic libraries.The development of plasmonic library is basically determined by the nanofabrication techniques. Conventional lithography (hard lithography) techniques, such as electron beam lithography (EBL) and focused ion beam lithography (FIB), are most widely used to introduce ordered and well-defined gradient nanostructures. While these techniques are capable of precise control over the size, shape, and spacing of metallic nanostructures, they are limited by high cost, low throughput, and requirement of sophisticated equipment. [9,10,17,20] Recent research has been focused on developing low-cost and efficient unconventional techniques to produce gradient plasmonic structures (GPSs). Fery and co-workers used a dip-coating Gradient plasmonic nanostructures are produced by a straightforward and powerful fabrication strategy-deposition on curved nanomask (DCNM), a physical vapor deposition on a curved mask substrate covered with a mono layer of closepacked nanospheres. The feasibility of the DCNM strategy is demonstrated by producing wellordered Ag gradient single/double nanotri angle (NT) arrays with continuously adjustable color, extinction, localized sur face plasmon resonance wavelen...

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Section: Resultsmentioning

confidence: 98%

A Flexible Strategy to Fabricate Gradient Plasmonic Nanostructures

Larson

Bradley

et al. 2018

Adv Materials Inter

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“…The high‐density nanodots endowed this substrate with a sensitive and nanodot‐thickness‐dependent SERS response . Through the AAO template‐based method, Xu and co‐workers obtained a silver nanodot array and integrated it into a microfluid system . The combination of microfluid technology substantially enhanced the sensitivity of the nanodot array, with which a low detection limit of 5.0×10 −7 m for thiram was achieved (Figure a,b).…”

Section: Advanced Morphology Features Of Nanostructured Arrays Preparmentioning

confidence: 99%

“…Reproduced with permission from Ref. , Copyright 2014, The Royal Society of Chemistry. c,d) Ag nanodot arrays for SERS applications that exhibit the highest sensitivity if the Ag nanodot diameter is 70 nm.…”

Section: Advanced Morphology Features Of Nanostructured Arrays Preparmentioning

confidence: 99%

Template‐Assisted Fabrication of Nanostructured Arrays for Sensing Applications

Lei

2018

ChemPlusChem

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High sensitivity imposes strict requirements on a sensing platform, for which nanostructured arrays are promising candidates. The template‐assisted method is an effective strategy to prepare various nanostructured arrays, which are widely developed for different sensing applications. Herein, nanostructured array based sensing platforms prepared from four widely used templates, a colloidal monolayer, anodic aluminum oxide, block copolymer, and a nanoimprint mold, are reviewed. In a series of sensing applications (e.g., biosensing and gas sensing), the resulting nanostructure‐array‐based platforms are high sensitive owing to their advanced morphology features: 1) high‐density alignment of arrayed nanostructures, 2) high surface‐to‐volume ratio, and 3) convex‐rich morphology. In surface‐enhanced Raman spectroscopy (SERS) applications, noble‐metal particle arrays with high‐density alignment produce an enhanced SERS signal owing to a strong concentration of plasmonic resonance on the substrate. To sense biomolecules in solution and gaseous molecules, arrays with a high surface‐to‐volume ratio or convex‐rich morphology can sensitively respond to changes in the environment. Moreover, the nanostructure‐array‐based sensing platforms are divided into three types (0D, 1D, and 3D nanostructured arrays) to demonstrate the morphological origin of the sensing performances.

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“…Generally speaking, the rough surface of metals, such as gold or silver, could contribute to a large enhancement of the adsorbed analyte's Raman signals. In recent years, with the rapid progress of microfluidics, the combination of SERS‐active substrates with portable microfluidic chips becomes more and more promising for the purpose of developing portable SERS detection devices . For example, the integration of SERS substrates within the microfluidic channel enables on‐chip detection and in situ monitoring of chemical reactions; the powerful microfluidic systems may, in turn, facilitate high through‐put SERS detection, and further promote the efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…For example, the integration of SERS substrates within the microfluidic channel enables on‐chip detection and in situ monitoring of chemical reactions; the powerful microfluidic systems may, in turn, facilitate high through‐put SERS detection, and further promote the efficiency. Thus far, various methods have been proposed to resolve the problem about how to integrate SERS substrates within a microfluidic chip, including metal colloid self‐assembly, electron beam or physical vapor deposition, soft lithography, and the use of natural materials . Although these fabrication techniques have successfully demonstrated the feasibility of making SERS‐active microfluidic chips, problems with respect to flexible and localized integration of a SERS substrate inside a microfluidic chip significantly limits their practical application in the development of SERS enabled microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

Femtosecond Laser Direct Writing of Plasmonic Ag/Pd Alloy Nanostructures Enables Flexible Integration of Robust SERS Substrates

Zhang

Han

et al. 2017

Adv Materials Technologies

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This paper demonstrates femtosecond laser direct writing mediated flexible integration of plasmonic Ag/Pd alloy nanostructures that can be potentially used as a robust surface-enhanced Raman spectroscopy substrate inside the microfluidic chip. Silver-palladium alloy with controllable composition ratio can be patterned into plasmonic nanostructures due to two-photon absorption induced coreduction of silver/palladium double metal ions. Since the alloy structures can effectively protect the silver from oxidation, thus they can facilitate the stable on-chip detection devices with long lifetime. The as-fabricated silver-palladium alloy substrate with 18% content of palladium maintains a relatively high enhancement factor of about 2.62 × 10 8 while at the same time demonstrating the best stability against aerobic oxidation, as it is stable for up to 20 d under ambient aerobic conditions, exhibiting a significant improvement compared to those unprotected silver substrates which have a limited lifetime of only 3 or 4 d. www.advmattechnol.de Figure 7. a) SERS spectra of R6G collected on the randomly selected nine points of the Ag-Pd alloy nanostructure. b) Corresponding intensity variation of the peaks at 1509 cm −1 .Figure 8. The comparison with respect to the drop in EF over time between the alloy and the pure silver nanostructures. All the enhancement factors are the result of average values after several times of calculation.

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A highly sensitive microfluidics system for multiplexed surface-enhanced Raman scattering (SERS) detection based on Ag nanodot arrays

Abstract: We present a microfluidics system with Ag nanodot arrays as the enhancement substrate for multiplexed SERS detection of low-concentration mixtures of thiram and adenine.

Cited by 39 publications

References 31 publications

A Flexible Strategy to Fabricate Gradient Plasmonic Nanostructures

A Flexible Strategy to Fabricate Gradient Plasmonic Nanostructures

Template‐Assisted Fabrication of Nanostructured Arrays for Sensing Applications

Femtosecond Laser Direct Writing of Plasmonic Ag/Pd Alloy Nanostructures Enables Flexible Integration of Robust SERS Substrates

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