A highly sensitive graphene oxide based label-free capacitive aptasensor for vanillin detection

Mohan, Hari Krishna Salila Vijayalal; Chee, Wai Kit David; Li, Yida; Nayak, Suryakanta; Poh, Chueh Loo; Thean, Aaron

doi:10.1016/j.matdes.2019.108208

Cited by 30 publications

(8 citation statements)

References 39 publications

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“…Because graphene has chemical stability in contact with electrolytes, mechanical elasticity and good electrical conductivity, it is widely used as a storage medium for lithium [72][73][74][75]. It is also used in gas sensors such as NO 2 , CO, H 2 S, H 2 , NO, NH 3 , and CO 2 [76][77][78][79][80][81][82][83][84][85], or even as a biosensor for the detection of dopamine [86,87], β-nicotinamide adenine dinucleotide [88], paracetamol [87,89], Kojic acid [90], uric acid [86,87], vanillin [91], and caffeic acid [92]. Graphene is also used as a drug carrier [93][94][95][96][97] and as a charge conductor in solar cells as well as a light collector including cells and photodetectors [53,[60][61][62][98][99][100].…”

Section: Graphite and Graphenementioning

confidence: 99%

Current State of Porous Carbon for Wastewater Treatment

et al. 2020

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Porous materials constitute an attractive research field due to their high specific surfaces; high chemical stabilities; abundant pores; special electrical, optical, thermal, and mechanical properties; and their often higher reactivities. These materials are currently generating a great deal of enthusiasm, and they have been used in large and diverse applications, such as those relating to sensors and biosensors, catalysis and biocatalysis, separation and purification techniques, acoustic and electrical insulation, transport gas or charged species, drug delivery, and electrochemistry. Porous carbons are an important class of porous materials that have grown rapidly in recent years. They have the advantages of a tunable pore structure, good physical and chemical stability, a variable specific surface, and the possibility of easy functionalization. This gives them new properties and allows them to improve their performance for a given application. This review paper intends to understand how porous carbons involve the removal of pollutants from water, e.g., heavy metal ions, dyes, and organic or inorganic molecules. First, a general overview description of the different precursors and the manufacturing methods of porous carbons is illustrated. The second part is devoted to reporting some applications such using porous carbon materials as an adsorbent. It appears that the use of porous materials at different scales for these applications is very promising for wastewater treatment industries.

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Section: Graphite and Graphenementioning

confidence: 99%

Current State of Porous Carbon for Wastewater Treatment

et al. 2020

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“…All the non-faradaic capacitance measurements on the sequentially modified LSG microgap were carried out in 4 µl of PBS (10 mM, pH 7.4) to provide a neutral biological condition for the interactions of biomolecules. Any disturbance presented at the triangular junction with the separation of 95 ± 1.33 µm leads to a change in capacitance characteristics over a frequency range 35 , 38 . Figure 4 a shows the capacitance measurement for different surface modified LSG microgaps.…”

Section: Resultsmentioning

confidence: 99%

1,1'-Carbonyldiimidazole-copper nanoflower enhanced collapsible laser scribed graphene engraved microgap capacitive aptasensor for the detection of milk allergen

Subramani

Perumal

Gopinath

et al. 2021

Sci Rep

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The bovine milk allergenic protein, ‘β-lactoglobulin’ is one of the leading causes of milk allergic reaction. In this research, a novel label-free non-faradaic capacitive aptasensor was designed to detect β-lactoglobulin using a Laser Scribed Graphene (LSG) electrode. The graphene was directly engraved into a microgapped (~ 95 µm) capacitor-electrode pattern on a flexible polyimide (PI) film via a simple one-step CO2 laser irradiation. The novel hybrid nanoflower (NF) was synthesized using 1,1′-carbonyldiimidazole (CDI) as the organic molecule and copper (Cu) as the inorganic molecule via one-pot biomineralization by tuning the reaction time and concentration. NF was fixed on the pre-modified PI film at the triangular junction of the LSG microgap specifically for bio-capturing β-lactoglobulin. The fine-tuned CDI-Cu NF revealed the flower-like structures was viewed through field emission scanning electron microscopy. Fourier-transform infrared spectroscopy showed the interactions with PI film, CDI-Cu NF, oligoaptamer and β-lactoglobulin. The non-faradaic sensing of milk allergen β-lactoglobulin corresponds to a higher loading of oligoaptamer on 3D-structured CDI-Cu NF, with a linear range detection from 1 ag/ml to 100 fg/ml and attomolar (1 ag/ml) detection limit (S/N = 3:1). This novel CDI-Cu NF/LSG microgap aptasensor has a great potential for the detection of milk allergen with high-specificity and sensitivity.

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“…Taken together, the Thermal-T7RNAPs has expanded the synthetic biology thermal control toolkit for biomedical (Abedi et al, 2020;Gamboa et al, 2020;Miller et al, 2018;Piraner et al, 2017) and industrial applications (Harder et al, 2018;Rodrigues et al, 2017;Salila Vijayalal Mohan et al, 2020;Wang et al, 2021;Xu et al, 2020) by providing an alternative mode of thermal regulation. The Thermal-T7RNAPs can be an useful addition for combinatorial multi-level temperature-based gene regulations (e.g.…”

Section: Discussionmentioning

confidence: 99%

Highly Reversible Tunable Thermal-repressible Split-T7 RNA polymerases (Thermal-T7RNAPs) for dynamic gene regulation

Chee

Yeoh

Dao

et al. 2021

Preprint

Self Cite

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Temperature is a physical cue that is easy to apply, allowing cellular behaviors to be controlled in a contactless and dynamic manner via heat-inducible/repressible systems. However, existing heat-repressible systems are limited and rely on thermal sensitive mRNA or transcription factors which function at low temperatures, lack tunability, suffer delays or overly-complex. To provide an alternative mode of thermal regulation, we developed a library of compact, reversible and tunable thermal-repressible split-T7 RNA polymerase systems (Thermal-T7RNAPs) which fuses temperature-sensitive domains of Tlpa protein with split-T7RNAP to enable direct thermal control of the T7RNAP activity between 30-42 °C. We generated a large mutant library with varying thermal performances via automated screening framework to extend temperature tunability. Lastly, using the mutants, novel thermal logic circuitry was implemented to regulate cell growth and achieve active thermal control of the cell proportions within co-cultures. Overall, this technology expands avenues for thermal control in biotechnology applications.

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A highly sensitive graphene oxide based label-free capacitive aptasensor for vanillin detection

Cited by 30 publications

References 39 publications

Current State of Porous Carbon for Wastewater Treatment

Current State of Porous Carbon for Wastewater Treatment

1,1'-Carbonyldiimidazole-copper nanoflower enhanced collapsible laser scribed graphene engraved microgap capacitive aptasensor for the detection of milk allergen

Highly Reversible Tunable Thermal-repressible Split-T7 RNA polymerases (Thermal-T7RNAPs) for dynamic gene regulation

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