A highly sensitive fluorescence turn-on platform with silver nanoparticles aptasening for human platelet-derived growth factor-BB

Thrombin-linked aptamer assay for detection of platelet derived growth factor BB on magnetic beads in a sandwich format

“…The limit of detection (LOD) on the basis of 3 times the standard deviation of the blank was 16 pM. This detection limit is comparable to or better than those reported by some aptamerbased assays for PDGF-BB [3,5,8,9,[48][49][50][51][52][53][54][55]. An aptamer proximity binding assay for fluorescent detection of PDGF-BB was reported, which did not require separation [53].…”

A signal-enhanced and sensitive lateral flow aptasensor for the rapid detection of PDGF-BB

“…The regression equation is Y ¼ 144.6X + 25.13 with a correlation coefficient of 0.9902, where Y is peak area of the test line, and X is the log concentration of PDGF-BB. This enhanced response provided several advantages over previously published methods (Table 2), [33][34][35][36][37][38][39][40] and was 1000 times smaller than the traditional double sandwich antibody lateral ow biosensor (Fig. 6).…”

An electrochemical impedance aptasensor based on selenomolybdate nanodot/antimonene hybrid for platelet-derived growth factor-BB

“…The hybrid bioelectrode's detection limit (three times signal-tonoise ratio) was found to be 3.5 pM, which was significantly lower than those published previously in the literature, demonstrating the superiority of the current sensing platform (Table 3). 16,[52][53][54] The bioelectrode's stability was further tested by repeating EIS measurements using the same dispensed PDGF-BB-spiked PB and measuring the related R et response. Even after more than three repeated observations, a virtually constant R et response was seen, showing that the bioelectrode in solution was stable.…”