“…3.1.4.1, E.C. 3.6.1.8, and 3.6.1.9) represent a group of conserved eukaryotic proteins that are expressed both as transmembrane ecto-enzymes and as soluble proteins in body fluids [1,2]. Three members of the NPP family hydrolyze nucleotides, namely, NPP1 (PC-1), NPP2 (autotaxin), and NPP3 (B10, gp130 [3,4].…”