A highly sensitive and selective biosensor based on nitrogen-doped graphene for non-enzymatic detection of uric acid and dopamine at biological pH value

Foroughi, Faranak; Rahsepar, Mansour; Kim, Hasuck

doi:10.1016/j.jelechem.2018.09.008

Cited by 29 publications

(14 citation statements)

References 40 publications

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“…However, their high price and low natural abundance limit their application. Carbon‐based materials, like multi‐walled carbon nanotubes (MWCNT) [15], graphen oxide (GO) [16], doped graphene [17] and functionalized carbon nanotubes with noble/non‐noble metals, metal oxides and conducting polymers (FCNT) [18–25], have also attracted the attention of scientists due to their excellent physical and chemical properties. Reedy et al.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Enzyme‐free Sensor Based on a Carbon Paste Electrode Modified with Binary Zinc Oxide/Polyaniline Nanocomposites for Dopamine, Ascorbic Acid and Uric Acid Sensing

Kadri

Bekri-Abbess²,

Herrasti

2022

Electroanalysis

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Hybrid composites ZnO/PANI were facily synthesized by a sonication process at room temperature. This procedure is non-expensive, time/energy saving and environmentally safe. The as-prepared ZnO/PANI were characterized by FTIR, UV-vis spectroscopies and SEM in order to investigate the structure and morphology of the studied composites. The samples were used to modify carbon paste electrode (CPE) in order to develop electrochemical biosensors (ZnO/PANI/CPE). The sensing properties of the nanoparticles were evaluated for dopamine, ascorbic acid and uric acid non-enzymatic detection. The effect of percentage of polyaniline in the composites and the effect of calcination on the biosensor's response were also examined in the present study. It was revealed that the existence of PANI in ZnO/PANI/CPE largely enhanced the electroactive surface area and therefore the sensitivity for electrochemical sensing. A good electrochemical behavior was noted for ZnO/40 wt% PANI-cal/ CPE modified electrode toward DA, AA and UA oxidation. The electroactive surface area of the previously mentioned modified electrode (0.235 cm 2 ) was two times higher than that of the bare electrode (0.117 cm 2 ). The liner relationships between current intensities and concentrations were found to be 0.01-1.4 mM, 0.1-1.3 mM and 0.01-0.12 mM, with detection limit of 0.029 mM, 0.063 mM and 0.007 mM, for DA, AA and UA respectively. In the mixtures of ascorbic acid (AA), dopamine (DA) uric acid (UA) and glucose (Glu) the sensor showed high selectivity of DA with low interference of ascorbic acid by a current change of 14 %. The asprepared ZnO/PANI/CPE biosensor displayed a good reproducibility and stability.

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Section: Introductionmentioning

confidence: 99%

Highly Sensitive Enzyme‐free Sensor Based on a Carbon Paste Electrode Modified with Binary Zinc Oxide/Polyaniline Nanocomposites for Dopamine, Ascorbic Acid and Uric Acid Sensing

Kadri

Bekri-Abbess²,

Herrasti

2022

Electroanalysis

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“…The limit of detection was found to be 2.85 lM (based on 3.3 S b /m) and is well within the range expected for UA within many biofluids. The response sensitivity was 361 lA mM -1 cm -2 and, while many literature reports fail to provide comparative data, of those that do [32][33][34], the system here appears competitive without having to undergo the more complex surface modifications.…”

Section: Resultsmentioning

confidence: 65%

Microneedle array sensors based on carbon nanoparticle composites: interfacial chemistry and electroanalytical properties

et al. 2019

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Conductive microneedle patches consisting of carbon nanoparticles embedded in a polystyrene matrix have been prepared using micro-moulding techniques. The interfacial properties of the structures before and after electrochemical etching have been characterised using X-ray photoelectron spectroscopy and contact angle. Anodisation of the needles leads to a significant increase in oxygen functionality and is shown to dramatically improve the electroanalytical capabilities of the microneedle array. The detection of uric acid in horse blood was used as a model system through which to assess the performance of the system. The composite approach is shown to lead to viable carbon-based sensors and can offer a rapid prototype option for the development of tailored microneedle systems.

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“…Graphene, a simple 2D material, has attracted significant attention since its discovery in 2004 by Novoselov and Geim . Due to its impressive theoretical traits such as: high surface area, capacitance, charge carrier mobility, and functionalization ability, graphene has a variety of applications for capacitors,, batteries,, and sensors ,. Graphene can be synthesized via numerous routes from graphite, graphene oxide (GO), and even gases such as methane .…”

Section: Methodsmentioning

confidence: 99%

A One‐Pot Synthesis of Platinum Nanoparticles on Electrochemically Exfoliated Graphite

2019

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Graphite rods were electrochemically exfoliated in an aqueous solution of H2PtCl6 at potentials ranging from 2.5 V to 10 V. The solution was then directly reduced in the same pot with hydrazine hydrate. Scanning Electron Microscopy (SEM) confirmed the platinum deposition onto the exfoliated graphene while Raman spectroscopy and X‐Ray Diffraction (XRD) displayed varying degrees of disorder and oxidation in the graphitic lattices exfoliated at the various potentials. Half‐cell electrochemical tests showed the reduced graphene oxide supported platinum catalysts exfoliated at 5 V displayed the highest electrochemical activity for oxygen reduction in the acidic media while the catalyst exfoliated at 8 V displayed the lowest activity.

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A highly sensitive and selective biosensor based on nitrogen-doped graphene for non-enzymatic detection of uric acid and dopamine at biological pH value

Cited by 29 publications

References 40 publications

Highly Sensitive Enzyme‐free Sensor Based on a Carbon Paste Electrode Modified with Binary Zinc Oxide/Polyaniline Nanocomposites for Dopamine, Ascorbic Acid and Uric Acid Sensing

Highly Sensitive Enzyme‐free Sensor Based on a Carbon Paste Electrode Modified with Binary Zinc Oxide/Polyaniline Nanocomposites for Dopamine, Ascorbic Acid and Uric Acid Sensing

Microneedle array sensors based on carbon nanoparticle composites: interfacial chemistry and electroanalytical properties

A One‐Pot Synthesis of Platinum Nanoparticles on Electrochemically Exfoliated Graphite

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