A highly sensitive and selective fluorescein-based fluorescence probe for Au3+ and its application in living cell imaging

Srinivasulu, K.; Wang, Bihui; Wang, Fang; Wang, Yong; Chen, Haiyan; Yin, Jun; Chen, Xiaoqiang

doi:10.1016/j.snb.2014.12.085

Cited by 56 publications

(19 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gold ions are known to activate carbon-carbon multiple bonds, especially alkynes, toward nucleophilic addition. Owing to the characteristic alkynophilicity of the gold ion, a variety of organic transformations have been investigated by employing gold ions (Hashmi et al, 2008;Jun et al, 2011;Kambama et al, 2015;Liu et al, 2010;Pina et al, 2008;Wang et al, 2009;Wang et al, 2012) and based on gold-ion-promoted cyclizations from the non-fluorescent apocoumarin to the strongly fluorescent coumarin (Do et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes

Yang

Bai

Jin

et al. 2016

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Two new acetylenic compounds were designed and synthesized as the probes to realize the detection and recognition of Au(3+). The latent fluorophores was rearranged into the fluorescent coumarin derivatives with strong fluorescence by a gold ion-mediated hydroarylation reaction. In the meanwhile, the generated fluorescent substances were also isolated and characterized. The probes identified Au(3+) ions highly selectively over other biologically relevant metal ions, and detection concentration of Au(3+) was as low as 0.1µM or less. Fluorescent imaging of Au(3+) in living cells was also successfully demonstrated.

show abstract

Section: Introductionmentioning

confidence: 99%

Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes

Yang

Bai

Jin

et al. 2016

Biosensors and Bioelectronics

View full text Add to dashboard Cite

show abstract

“…For example, an acidic pH can usually activate a nonfluorescent rhodamine spirolactam to be a highly fluorescent rhodamine derivative . Recently, rhodamine‐based sensors for cations and other analytes have received ever‐increasing interest in areas such as sensors for Pb 2+ , Cu 2+ , Hg 2+ , Fe 3+ , Cr 3+ , Au 3+ , NO, and OCl − . Our research expands expertise and knowledge in a rhodamine B derivative synthesis that can help to design and develop chemosensors based on rhodamine B derivative …”

Section: Introductionmentioning

confidence: 84%

Spray coating thin polymeric sensor films for Au³⁺

Chansri

Wanno

Keawwangchai

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

A novel polymeric sensor of the poly(sodium-4-styrenesulfonate) (PSS)-modified rhodamine B derivative (Rho) was synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/N,N 0 -dimethylpyridin-4-amine (DMAP) as coupling reagents to obtain PSS-Rho4 in 21% yield. The characterization and "Off-On" sensing phenomena were established through UV-Vis, fluorescence, NMR, and FTIR techniques. The PSS-Rho4 showed high selectivity and sensitivity for Au 3+ over other metal ions. Upon the addition of Au 3+ , significant color change and "Off-On" fluorescence were observed due to a cation Au 3+ induced spirolactam ring-opening process with detection limit down to micromolar values (1.2 μM). In addition, spray coating thin polymeric sensor films were produced onto the surface of material (PSS-Rho4-ITO and PSS-Rho4-filtered paper) providing a fast, portable, and easy-to-use molecular device for the detection of Au 3+ in the real system. Reversibility was evaluated by rinsing with EDTA solution under basic condition. We believe that, this approach provides a sensitive and accurate method for the detection of Au 3+ in environmental and biological applications.

show abstract

“…After the cells absorb dyes, a series of metabolic processes are carried out to reach the corresponding sites. At present, fluorescent dyes used for fluorescence imaging labeling mainly include fluorescein [2], cyanine [3], rhodamine [4,5], triphenylamine [6,7], fluoroboron fluorescein [8]. But most of the organic small molecule fluorescent dyes have high cytotoxicity and poor biocompatibility, so cell imaging has limitations.…”

Section: Discussionmentioning

confidence: 99%

Establishment of Fluorescence Sensitization Method for Hydroxysafflor Yellow A

Cao

Qin

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

As the main active ingredient in Chinese medicine safflower, hydroxysafflor yellow A (HSYA) has multiple pharmacological effects. In the work, the absorption and fluorescence spectra of HSYA under different environmental conditions (such as acidity, temperature, ions, viscosity, and surfactant) were investigated. The fluorescence intensity of HSYA varied greatly with acidity, temperature, viscosity, and surfactant, but was less affected by common cations and anions. Among various surfactants, we found that borax can significantly enhance the HSYA fluorescence intensity, and thus, a borax-HSYA sensitization system for HSYA fluorescence was established. In the optimized sensitization system, the fluorescence intensity of HSYA increased by 20 times and showed a good linearity with HSYA concentrations in the range of 0∼10 μM with a detection limit of 8 nM. The borax-HSYA sensitization system is nontoxic to T24 cells and mice and can be used for the fluorescence imaging of HSYA in cells, thereby providing an effective method for analyzing HSYA in vitro and monitoring its metabolism in cells.

show abstract

A highly sensitive and selective fluorescein-based fluorescence probe for Au3+ and its application in living cell imaging

Cited by 56 publications

References 48 publications

Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes

Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes

Spray coating thin polymeric sensor films for Au³⁺

Establishment of Fluorescence Sensitization Method for Hydroxysafflor Yellow A

Contact Info

Product

Resources

About

A highly sensitive and selective fluorescein-based fluorescence probe for Au3+ and its application in living cell imaging

Cited by 56 publications

References 48 publications

Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes

Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes

Spray coating thin polymeric sensor films for Au3+

Establishment of Fluorescence Sensitization Method for Hydroxysafflor Yellow A

Contact Info

Product

Resources

About

Spray coating thin polymeric sensor films for Au³⁺