A highly sensitive and selective enzyme activated fluorescent probe for in vivo profiling of carboxylesterase 2

New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis

“…The detection limit of the probe was calculated to be as low as 0.3 ng/mL (3S/N), which was lower than that previously reported in the literature (Table S1). ,,,− Figure C shows that MOR-CES2 could resist interference from common endogenous ions and substances, which was indicative of its high selectivity. The kinetic relationship between MOR-CES2 and CES2 was comprehensively examined.…”

Cytotoxicity of AuCu–Cu2S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

“…In this present study, the genes involved in the metabolism of cofactors and vitamins, xenobiotic biodegradation metabolism, amino acid metabolism, and carbohydrate metabolism peaked in the fat body. Carboxylic ester (COE) hydrolases, KWMTBOMO08294, are multigene superfamily enzymes involved in a wide range of biological functions such as neural transmission, reproduction development, pheromone degradation, and a number of ester-containing xenobiotics such as drugs, insecticides, and environmental toxicants . COEs are one of the most important detoxification enzyme systems in insects, participating in the metabolic detoxification of xenobiotics.…”

“…Carboxylic ester (COE) hydrolases, KWMTBOMO08294, are multigene superfamily enzymes involved in a wide range of biological functions such as neural transmission, reproduction development, pheromone degradation, and a number of estercontaining xenobiotics such as drugs, insecticides, and environmental toxicants. 52 COEs are one of the most important detoxification enzyme systems in insects, participating in the metabolic detoxification of xenobiotics. Previous studies have reported that carboxylic ester genes are mostly expressed in the larval stages of insects.…”

A carboxylesterase-activatable near-infrared phototheranostic probe for tumor fluorescence imaging and photodynamic therapy

“…[27][28][29][30][31][32] Besides, some CESresponsive uorescence probes for single imaging were proposed. [33][34][35][36][37][38][39][40][41][42][43][44][45] These probes were generally designed by incorporating varied substrates with carboxyl groups into uorophores with hydroxyl groups, which displayed rational sensitivity and selectivity toward CES. They have been used for bioimaging at cellular level or in vivo, verifying the feasibility of such sensing strategy.…”