2008
DOI: 10.1021/ja806928n
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A Highly Sensitive and Selective OFF-ON Fluorescent Sensor for Cadmium in Aqueous Solution and Living Cell

Abstract: A highly selective and sensitive OFF-ON fluorescent sensor 1, employing the PET mechanism, was designed and synthesized. It could be used to detect Cd(2+) ion in aqueous solution and to image Cd(2+) ion in living cells. The fluorescence intensity significantly enhanced about 195-fold and the quantum yield increased almost 100-fold. Moreover the fluorescence intensity of 1 increased linearly with high sensitivity (0-1 microM) toward Cd(2+).

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Cited by 335 publications
(139 citation statements)
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“…The hexadentate donor motif 81 utilizes amides rather than acetates to bind Hg 2+ or Cd 2+ , the PET-type signaling of which is monitored by conjugated (94)(95)(96) or tethered (97 and 98) fluorophores [96][97][98][99]. …”
Section: Strategymentioning
confidence: 99%
“…The hexadentate donor motif 81 utilizes amides rather than acetates to bind Hg 2+ or Cd 2+ , the PET-type signaling of which is monitored by conjugated (94)(95)(96) or tethered (97 and 98) fluorophores [96][97][98][99]. …”
Section: Strategymentioning
confidence: 99%
“…Organic solid-state photoactive chromophores have received increasing attention during the past 20 years due to their unique optical properties and promising optoelectronic applications in the fields of lasers [1,2], sensors [3][4][5][6][7], and biological imaging [8][9][10]. Meanwhile, more and more research attention has been paid to molecule-based micro/nanomaterials in chemistry, materials science, and pharmaceutics/medicine [11][12][13][14], since micro/nanomaterials exhibit unique properties superior to those of their bulk counterparts [15,16], owing to their surface effect, quantum size effect [17,18], and so on.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, many fluorescent sensors for sensing metal ions (such as Zn(II) [7], Cd(II) [8], Cu(II) [9], Pb(II) [10], Hg(II) [11] and Cr(III) [12]) have been successfully designed and synthesized. Although some chromogenic sensor for Ni(II) ion have been reported [13], the fluorescent sensor for Ni(II) ions is extremely rare.…”
Section: Introductionmentioning
confidence: 99%