A highly selective turn-on fluorescent probe for Al(iii) based on coumarin and its application in vivo

Abstract

In this study, a turn-on coumarin-based fluorescent probe, 7-hydroxy-6-[(2-hydroxy-naphthalen-1-ylmethylene)-amino]-4-methyl-chroman-2-one (CN), was developed for detecting Al(3+) in aqueous systems. The binding ratio of CN-Al(3+) complexes was determined from the Job plot and ESI-MS data to be 1 : 1. The binding constant (Ka) of Al(3+) binding to CN was calculated to be 9.55 × 10(4) M(-1) from a Benesi-Hildebrand plot and the detection limit was evaluated to be as low as 0.10 μM (LOD = 3σ/slope). CN could be used as an effective fluorescent probe for detecting Al(3+) in living HeLa cells. Moreover, CN could also be applied in the in vivo detection of Al(3+) in zebrafish.

Loading, Unloading and Receiving of Selected Molecules with Nanomolar Sensitivity in Molecular Communication: Unprompted Carrier‐to‐Carrier Transformation

“…In contrast, we got high intensity emission band at 440 nm only in presence of ZA (λ ex =350 nm) (Figure b; Figure S3, ESI). This beautiful “turn‐ON” fluorescence response of 2‐IMP‐ZA might be attributed to the suppression of the PET or stabilization of extended charge transfer (CT) state through metal centres (Zn II ) and chelation enhanced fluorescence (CHEF) mechanism . It was noticed that after complexation of 2‐IMP with ZA, resultant complex adopted more spherical and compact structure.…”

A Sensitive Colorimetric and Ratiometric Chemosensor for Trivalent Metal Cations

“…Meanwhile, the industrial discard of Cr 3+ causing serious environmental pollution is a matter of great concern in agriculture [3,10]. As to Al 3+ , both deficiency and excess of Al 3+ has also been linked with several serious diseases [11]. And the increase of Al 3+ caused by acidic rain and human activities is detrimental to plants [10].…”

The fluorescence turn-off mechanism of a norbornene-derived homopolymer – an Al3+ colorimetric and fluorescent chemosensor

“…[8][9][10] In recent years, significant progress has been made in detecting Al 3+ using a fluorescent chemosensor. [11][12][13][14][15][16] Because of the individual photophysical properties and the strong binding abilities to Al 3+ ions, Schiff base derivatives have been widely investigated as fluorescent chemosensors for Al 3+ detection. [17][18][19][20][21][22][23][24][25] Most of the Schiff base-derived fluorescent chemosensors are small molecules.…”