A highly selective LSPR biosensor for the detection of taurine realized on optical fiber substrate and gold nanoparticles

Sharma, Priyanka; Semwal, Vivek; Gupta, Banshi D.

doi:10.1016/j.yofte.2019.101962

Cited by 28 publications

(12 citation statements)

References 17 publications

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“…Fiber optic biosensors have been exploited as sensor platforms for a variety of applications such as sensing glucose 35 – 42 , sucrose 36 , heavy metal ions such as lead, copper, cobalt, cadmium 43 – 45 , amino acids 46 , cholesterol 47 , triacylglycerides 48 , urea 49 , ascorbic acid 50 , DNA 34 , 51 , proteins including thrombin 52 – 54 , cancer biomarkers 55 , 56 and cytokeratin 57 , 58 , antibodies 59 , bacterial 60 – 62 and mammalian cells 63 , 64 .…”

Section: Introductionmentioning

confidence: 99%

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Bekmurzayeva

Ashikbayeva

Myrkhiyeva

et al. 2021

Sci Rep

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Increased level of CD44 protein in serum is observed in several cancers and is associated with tumor burden and metastasis. Current clinically used detection methods of this protein are time-consuming and use labeled reagents for analysis. Therefore exploring new label-free and fast methods for its quantification including its detection in situ is of importance. This study reports the first optical fiber biosensor for CD44 protein detection, based on a spherical fiber optic tip device. The sensor is easily fabricated from an inexpensive material (single-mode fiber widely used in telecommunication) in a fast and robust manner through a CO2 laser splicer. The fabricated sensor responded to refractive index change with a sensitivity of 95.76 dB/RIU. The spherical tip was further functionalized with anti-CD44 antibodies to develop a biosensor and each step of functionalization was verified by an atomic force microscope. The biosensor detected a target of interest with an achieved limit of detection of 17 pM with only minor signal change to two control proteins. Most importantly, concentrations tested in this work are very broad and are within the clinically relevant concentration range. Moreover, the configuration of the proposed biosensor allows its potential incorporation into an in situ system for quantitative detection of this biomarker in a clinical setting.

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Section: Introductionmentioning

confidence: 99%

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Bekmurzayeva

Ashikbayeva

Myrkhiyeva

et al. 2021

Sci Rep

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“…The limit of quantification (LOQ) represents the lowest concentration at which the analyte concentration can be reliably detected and goals for bias and imprecision can be met and is expressed mathematically as Equation ( 2). [48] Table 5 gives the key biomarkers implicated in cerebral edema formation and provides the data on selectivity, sensitivity, LOD, and LOQ (Acquired from Sharma et al, [49] Acquired from Ben Ismail et al, [50] ).…”

Section: Quantitative Discussion On Sensor Performancementioning

confidence: 99%

Recent Technological Developments in the Diagnosis and Treatment of Cerebral Edema

Deshmukh

Dabbagh

Jiang

et al. 2021

Advanced NanoBiomed Research

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Latest technological advancements in neurocritical care have translated to improved clinical outcomes and have paved the way for the effective diagnosis and treatment of cerebral edema. Effective management of cerebral edema has the potential to provide a personalized treatment by obtaining the complete pathophysiological information of the patient. The aims of this review are to inform the reader about the research and development in this field in the past decade as well as the materialization of scientific literature through patents. There is a growing interest in multimodal monitoring of the diseased brain as it provides a necessary means to implement effective intervention strategies. Although there is a gradual shift toward the adoption of noninvasive devices for research purposes, their clinical applications are hindered by their inaccuracies. However, the inherent risk of complication and high costs of implementation challenge the status quo. The role of neuroprotectants is explored and the combination of neurodiagnostic and neuroprotective approaches is proposed. Finally, the impacts of the current state of global affairs are discussed and it is predicted that the rising number of traumatic brain injury patents will inevitably translate to improvements in technologies to effectively address cerebral edema.

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“…In addition, LSPR-based sensors have also been the focus of extensive research, having demonstrated promising performance results [ 38 , 39 ]. In this optical detection technique, the incident light waves are confined within conductive NPs, whose dimensions are inferior to the wavelength of the light.…”

Section: Theoretical Background On Optical Fiber Biosensing Working Principlesmentioning

confidence: 99%

Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented.

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A highly selective LSPR biosensor for the detection of taurine realized on optical fiber substrate and gold nanoparticles

Cited by 28 publications

References 17 publications

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein

Recent Technological Developments in the Diagnosis and Treatment of Cerebral Edema

Immunosensing Based on Optical Fiber Technology: Recent Advances

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