A highly selective and simultaneous determination of paracetamol and dopamine using poly-4-amino-6-hydroxy-2-mercaptopyrimidine (Poly-AHMP) film modified glassy carbon electrode

Kannan, Ayyadurai; Sevvel, Ranganathan

doi:10.1016/j.jelechem.2017.03.002

Cited by 46 publications

(15 citation statements)

References 40 publications

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“…The values found presented satisfactory concordance with the spiking values, which indicates good accuracy of the electrochemical device and makes it suitable and efficient for the analysis of DOPA and AC, as well as for the analysis of other electroactive substances. Furthermore, even without the use of surface modifiers, the device described here was able to detect DOPA and AC in the samples at the same micromolar range such as described in previous works that employ more expensive and complex modified electrodes . Supporting Information presents some voltammograms and standard addition curves obtained from one of the determinations carried out in the spiked samples.…”

Section: Resultsmentioning

confidence: 97%

Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

et al. 2019

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This paper describes the development of a novel, simple, and inexpensive electrochemical device containing an integrated and disposable three‐electrode system for detection. The base of this platform consists on a PDMS structure containing microchannels which were prototyped using 3D‐printed molds. Pencil graphite leads were inserted into these microchannels and utilized as working, counter and reference electrodes in a novel design. Morphological analysis and electrochemical experiments with benchmark redox probes were carried out in order to evaluate the performance and characterize the miniaturized device proposed. Even using inexpensive materials and a simple fabrication protocol, the electrochemical platform developed provided good repeatability and reproducibility over a low cost (ca. $2 per device), acceptable lifetime (ca. 250 voltammetric runs) and extremely reduced consumption of samples and reagents (order of µL). As proof of concept, the analytical feasibility of the platform was investigated through the simultaneous determination of dopamine (DOPA) and acetaminophen (AC). The two analytes showed linear dependence on the concentration range from 1 to 15 µM and the LODs achieved were 0.21 µM for DOPA and 0.29 µM for AC. Moreover, the platform was successfully applied on the determination of DOPA and AC in spiked blood serum and urine samples. The results obtained with the device described here were better than some reports in literature that use more costly electrodic materials and complex modification steps for the detection of the same analytes.

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Section: Resultsmentioning

confidence: 97%

Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

et al. 2019

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“…This low LOD was ascribed to a high electroactive surface area and fast electron transfer. A highly-selective sensor for DA was developed using poly-4-Amino-6-hydroxy-2-mercaptopyrimidine (Poly-AHMP) film over a glassy carbon electrode [ 104 ]. A highly rough and porous surface was observed in SEM images of the film resulting in an increased active surface area of the electrode.…”

Section: Electrochemical Sensors Based On Conducting Polymersmentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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Electrochemical sensors appear as low-cost, rapid, easy to use, and in situ devices for determination of diverse analytes in a liquid solution. In that context, conducting polymers are much-explored sensor building materials because of their semiconductivity, structural versatility, multiple synthetic pathways, and stability in environmental conditions. In this state-of-the-art review, synthetic processes, morphological characterization, and nanostructure formation are analyzed for relevant literature about electrochemical sensors based on conducting polymers for the determination of molecules that (i) have a fundamental role in the human body function regulation, and (ii) are considered as water emergent pollutants. Special focus is put on the different types of micro- and nanostructures generated for the polymer itself or the combination with different materials in a composite, and how the rough morphology of the conducting polymers based electrochemical sensors affect their limit of detection. Polypyrroles, polyanilines, and polythiophenes appear as the most recurrent conducting polymers for the construction of electrochemical sensors. These conducting polymers are usually built starting from bifunctional precursor monomers resulting in linear and branched polymer structures; however, opportunities for sensitivity enhancement in electrochemical sensors have been recently reported by using conjugated microporous polymers synthesized from multifunctional monomers.

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“…The non-carbon nanomaterials used in the electrochemical detection of PCT regroup a wide variety of materials ranging from metals, metal oxides, ceramics and polymers. Table 3 [ [18] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] ] lists the PCT sensors based on non-carbon nanostructure modified electrodes reported up to date.…”

Section: Non-carbon Nanomaterials Modified Electrodesmentioning

confidence: 99%

“…Also, the reproducibility, repeatability, and shelf-life of the mentioned sensor were not determined. In a work done by Kannan and Sevvel [ 68 ], CV assisted electro-polymerized poly-4-amino-6-hydroxy-2-mercaptopyrimidine (poly-AHMP) has been also investigated for GCE modification. In this study, PCT was detected down to LOD of 0.15 μM with good recoveries (96%–102.75%) in tablet samples.…”

Section: Non-carbon Nanomaterials Modified Electrodesmentioning

confidence: 99%

“…The selection of the most suitable electrochemical technique is an important factor for the achievement of high selectivity and detecting trace levels of PCT. CV [ 25 , 58 , 67 , 72 ], DPV [ 18 , 19 , 40 , 43 , [52] , [53] , [54] , [55] , [56] , [57] , [59] , [60] , [61] , [62] , [64] , [65] , [66] , [67] , [68] , 70 , 72 , 73 , [76] , [77] , [78] , [79] , [83] , [84] , [85] , 87 , 89 , 92 , 93 , 95 , 97 , 98 , 101 , 103 , 106 , 108 , [110] , [111] , [112] , [113] , [114] , [115] , 119 , [121] , [122] , [123] , [125] , [126] , [127] , [128] , [129] , [130] , [131] , [132] , 134 ] and SWV [ 17 , 34 , 36 , 38 , 41 , 75 ...…”

Section: Critical Issues In Pct Detectionmentioning

confidence: 99%

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Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples

Boumya

Taoufik

Achak

et al. 2021

Journal of Pharmaceutical Analysis

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Paracetamol is a non-steroidal, anti-inflammatory drug widely used in pharmaceutical applications for its sturdy, antipyretic and analgesic action. However, an overdose of paracetamol can cause fulminant hepatic necrosis and other toxic effects. Thus, the development of advantageous analytical tools to detect and determine paracetamol is required. Due to simplicity, higher sensitivity and selectivity as well as costefficiency, electrochemical sensors were fully investigated in last decades. This review describes the advancements made in the development of electrochemical sensors for the paracetamol detection and quantification in pharmaceutical and biological samples. The progress made in electrochemical sensors for the selective detection of paracetamol in the last 10 years was examined, with a special focus on highly innovative features introduced by nanotechnology. As the literature is rather extensive, we tried to simplify this work by summarizing and grouping electrochemical sensors according to the by which manner their substrates were chemically modified and the analytical performances obtained.

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A highly selective and simultaneous determination of paracetamol and dopamine using poly-4-amino-6-hydroxy-2-mercaptopyrimidine (Poly-AHMP) film modified glassy carbon electrode

Cited by 46 publications

References 40 publications

Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

Design of novel, simple, and inexpensive 3D printing‐based miniaturized electrochemical platform containing embedded disposable detector for analytical applications

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples

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