A Highly Photostable Hyperbranched Polyglycerol‐Based NIR Fluorescence Nanoplatform for Mitochondria‐Specific Cell Imaging

Dong, Chunhong; Liu, Zhongyun; Liu, Junqing; Wu, Changzhu; Neumann, Falko; Wang, Hanjie; Schäfer‐Korting, Monika; Kleuser, Burkhard; Chang, Jin; Li, Wenzhong; Ma, Nan; Haag, Rainer

doi:10.1002/adhm.201600212

Cited by 26 publications

(12 citation statements)

References 45 publications

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“…Photoluminescent nanosystems have garnered great interest due to their excellent optical properties, low cost, photostability, convenience, and highly sensitive detection. 1 Recently, ultrasmall (<2 nm) photoluminescent gold nanoclusters (AuNCs) have been identified as promising candidates for cell labeling, biosensing, 2 photo-therapy applications, 3 cancer radiotherapy, 4,5 and antimicrobial agents. 6 Photoluminescent AuNCs are biocompatible and readily bioconjugable, and they show good photostability and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoclusters with bright near-infrared photoluminescence

et al. 2018

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The increase in nonradiative pathways with decreasing emission energy reduces the luminescence quantum yield (QY) of near-infrared photoluminescent (NIR PL) metal nanoclusters. Efficient surface ligand chemistry can significantly improve the luminescence QY of NIR PL metal nanoclusters. In contrast to the widely reported but modestly effective thiolate ligand-to-metal core charge transfer, we show that metal-to-ligand charge transfer (MLCT) can be used to greatly enhance the luminescence QY of NIR PL gold nanoclusters (AuNCs). We synthesized water-soluble and colloidally stable NIR PL AuNCs with unprecedentedly high QY (∼25%) upon introduction of triphenylphosphonium moieties into the surface capping layer. By using a combination of spectroscopic and theoretical methods, we provide evidence for gold core-to-ligand charge transfer occurring in AuNCs. We envision that this work can stimulate the development of these unusually bright AuNCs for promising optoelectronic, bioimaging, and other applications.

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Section: Introductionmentioning

confidence: 99%

Gold nanoclusters with bright near-infrared photoluminescence

et al. 2018

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“…The lysosomal escape capability of the TPP‐MNPs could be facilitated by the highly positive charges of multivalent amine groups and a “proton sponge effect” associated with PLL . The last step was the mitochondria targeting induced by the TPP under the high mitochondrial membrane potential ΔΨm …”

Section: Resultsmentioning

confidence: 99%

Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment

Chen

Ning

et al. 2019

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In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria‐targeted zinc‐doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep‐seated tumors in a spatiotemporal fashion.

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“…Ligands bearing TPP cations have been widely used for targeting mitochondria owing to the delocalized nature and high lipophilicity of these cations (Wang et al, 2014;Zhang et al, 2015;Dong et al, 2016;Hua et al, 2017;Wu X. et al, 2017;Zhang et al, 2017;Gong et al, 2019;Zhou et al, 2019). In 2014, Wang et al synthesized fluorescent TPP-conjugated CDs (TPP-CDs) by a hydrothermal method that could target mitochondria (Figure 4A) (Wang et al, 2014).…”

Section: Tpp Based Mitochondria Targeted Imagingmentioning

confidence: 99%

Lighting up Individual Organelles With Fluorescent Carbon Dots

et al. 2021

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Cell organelles play crucial roles in the normal functioning of an organism, therefore the disruption of their operation is associated with diseases and in some cases death. Thus, the detection and monitoring of the activities within these organelles are of great importance. Several probes based on graphene oxide, small molecules, and other nanomaterials have been developed for targeting specific organelles. Among these materials, organelle-targeted fluorescent probes based on carbon dots have attracted substantial attention in recent years owing to their superior characteristics, which include facile synthesis, good photostability, low cytotoxicity, and high selectivity. The ability of these probes to target specific organelles enables researchers to obtain valuable information for understanding the processes involved in their functions and/or malfunctions and may also aid in effective targeted drug delivery. This review highlights recently reported organelle-specific fluorescent probes based on carbon dots. The precursors of these carbon dots are also discussed because studies have shown that many of the intrinsic properties of these probes originate from the precursor used. An overview of the functions of the discussed organelles, the types of probes used, and their advantages and limitations are also provided. Organelles such as the mitochondria, nucleus, lysosomes, and endoplasmic reticulum have been the central focus of research to date, whereas the Golgi body, centrosome, vesicles, and others have received comparatively little attention. It is therefore the hope of the authors that further studies will be conducted in an effort to design probes with the ability to localize within these less studied organelles so as to fully elucidate the mechanisms underlying their function.

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A Highly Photostable Hyperbranched Polyglycerol‐Based NIR Fluorescence Nanoplatform for Mitochondria‐Specific Cell Imaging

Cited by 26 publications

References 45 publications

Gold nanoclusters with bright near-infrared photoluminescence

Gold nanoclusters with bright near-infrared photoluminescence

Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment

Lighting up Individual Organelles With Fluorescent Carbon Dots

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