A highly flexible paclitaxel-loaded poly(ε-caprolactone) electrospun fibrous-membrane-covered stent for benign cardia stricture

Zhang, Donghui; Hu, Changmin; Li, Bin; Yang, Huilin; Cheng, Yingsheng; Cui, Wenguo

doi:10.1016/j.actbio.2013.06.004

Cited by 62 publications

(46 citation statements)

References 38 publications

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“…21,22 Our study represents the rst implementation of staggerelectrospun hierarchical scaffolding system of dual scale bers, which are both stretchable and stiff for the augmentation of RCT repair. This improvement may be due to the nanofeatures of CS nanobers, which more closely resemble the native structures of the ECM, thus leading to better cell proliferation, ECM deposition and tissue regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…22,23 CS has been widely regarded as one of the most attractive natural biopolymers for bone tissue engineering owing to its structural similarity to glycosaminoglycan found in bone, along with its biocompatibility, biodegradability and high stiffness. According to previous studies, the electrospining of PCL has resulted in biocompatible scaffolds with high mechanical exibility, which may be suitable for engineering tendon tissues.…”

Section: Introductionmentioning

confidence: 99%

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A hierarchical, stretchable and stiff fibrous biotemplate engineered using stagger-electrospinning for augmentation of rotator cuff tendon-healing

Zhao

Dong

et al. 2015

J. Mater. Chem. B

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A hierarchical, stretchable and stiff fibrous biotemplate engineered using stagger-electrospinning for augmentation of rotator cuff tendon-healing

Zhao

Dong

et al. 2015

J. Mater. Chem. B

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“…21,22 Also polymer solutions were directly electrospun to bare metal stent using biodegradable and the biocompatible polymers were employed to coat the stent, such as PCL and polyurethane (PU). 23,24 More recently, PCL solid nanofiber-coated stent for paclitaxel delivery was developed. 25 However, there was no study of stent coating with coaxial nanofiber.…”

Section: Introductionmentioning

confidence: 99%

Multilayered electrospun fibrous meshes for restenosis-suppressing metallic stents

Son

Kim

Choi

et al. 2015

J. Biomed. Mater. Res.

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Nanofiber is a flexible and highly porous mesh that is advantageous for coating bare metal stent and local drug delivery. Herein, we developed drug‐eluting stent coated with PCL/PU blending coaxial nanofiber for controlling drug release manner and suppressing in‐stent restenosis, which is a representative side effect of stenting surgery. The shell of coaxial electrospun nanofibrous are composed of poly (ε‐caprolactone) (PCL) and polyurethane (PU) for biodegradability and elasticity to the polymeric coating of stent. Paclitaxel (PTX) is loaded into both the core and shell through electrospinning using coaxial nozzle with different weight ratio. The morphology of nanofiber‐coated stent, expansion state, and core/shell structure of nanofiber were visualized by scanning electron microscope and transmission electron microscope. As more amount of PCL/PU was infused from the outer nozzle, PTX release speed from the nanofiber was increased. And PTX suppressed L6 cell proliferation in vitro expecting potential possibility of PTX‐loaded coaxial nanofiber as a drug‐eluting stent coating material. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 628–635, 2017.

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“…Within the last decades electrospinning of polymers has emerged as a prominent technology for engineering nanofibers, which are explored for biomedical applications . In this context more recently the circumferential coating of stents with degradable polymeric nano‐ or microfibers acting as novel drug release systems for cancer or vascular diseases treatment has been introduced.…”

Section: Introductionmentioning

confidence: 99%

Encasement of metallic cardiovascular stents with endothelial cell‐selective copolyetheresterurethane microfibers

Sauter

Geiger

Kratz

et al. 2015

Polymers for Advanced Techs

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Cardiovascular metallic stents established in clinical application are typically coated by a thin polymeric layer on the stent struts to improve hemocompatibility, whereby often a drug is added to the coating to inhibit neointimal hyperplasia. Besides such thin film coatings recently nano/microfiber coated stents are investigated, whereby the fibrous coating was applied circumferential on stents. Here, we explored whether a thin fibrous encasement of metallic stents with preferentially longitudinal aligned fibers and different local fiber densities can be achieved by electrospinning. An elastic degradable copolyetheresterurethane, which is reported to selectively enhance the adhesion of endothelial cells, while simultaneously rejecting smooth muscle cells, was utilized for stent coating. The fibrous stent encasements were microscopically assessed regarding their single fiber diameters, fiber covered area and fiber alignment at three characteristic stent regions before and after stent expansion. Stent coatings with thicknesses in the range from 30 to 50 μm were achieved via electrospinning with 1,1,1,3,3,3-hexafluoro-2-propanol (HFP)-based polymer solution, while a mixture of HFP and formic acid as solvent resulted in encasements with a thickness below 5 μm comprising submicron sized single fibers. All polymeric encasements were mechanically stable during expansion, whereby the fibers deposited on the struts remained their position. The observed changes in fiber density and diameter indicated diverse local deformation mechanisms of the microfibers at the different regions between the struts. Based on these results it can be anticipated that the presented fibrous encasement of stents might be a promising alternative to stents with polymeric strut coatings releasing anti-proliferative drugs.

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A highly flexible paclitaxel-loaded poly(ε-caprolactone) electrospun fibrous-membrane-covered stent for benign cardia stricture

Cited by 62 publications

References 38 publications

A hierarchical, stretchable and stiff fibrous biotemplate engineered using stagger-electrospinning for augmentation of rotator cuff tendon-healing

A hierarchical, stretchable and stiff fibrous biotemplate engineered using stagger-electrospinning for augmentation of rotator cuff tendon-healing

Multilayered electrospun fibrous meshes for restenosis-suppressing metallic stents

Encasement of metallic cardiovascular stents with endothelial cell‐selective copolyetheresterurethane microfibers

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