A highly flexible green synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with CuI nanoparticles as catalyst under solvent-free conditions

CuII Anchored onto the Magnetic Talc: A New Magnetic Nanostructured Catalyst for the One‐Pot Gram‐Scale Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐dione Derivatives

“…Synthesis of 1 H ‐pyrazolo[1,2‐b]phthalazine‐5,10‐diones via multicomponent reaction (MCRs) is a powerful tool due to its advantages of the intrinsic atom economy, simple procedure, structural diversity, energy saving, and reduced waste . To the best of our knowledge, there are only several works of literature about the multicomponent reactions of phthalhydrazide, malononitrile with aldehydes in the presence of diverse catalysts such as PTSA/[Bmim]Br, Et 3 N/EtOH, [Bmim]OH/MW, 1,8‐diazabicyclo[5,4,0]‐undec‐7‐en‐8‐ium acetate, DBU[CH 3 CO 2 ], Al‐KIT‐6, NiCl 2 .6H 2 O, InCl 3 , CuI NPs, TBBDA or PBBS, CAN PEG 400, Ni 0.5 Zn 0.5 Fe 2 O 4 nano‐crystallites, SBA@BiPy 2+ 2Cl − , RH@[SiPrDABCO@BuSO 3 H]HSO 4 , ZrO 2 NPs, PbO NPs, ZnO NPs, DCDBTSD, DMAP, β‐Cyclodextrin, NaHCO 3 , p ‐toluenesulfonic acid, and Fe 3 ‐ x Ti x O 4 @ SiO 2 @urea MNPs . Despite the merits of the previously reported synthetic methods, the generality of some of the known procedures is somewhat defected by using catalysts and solvents which are not acceptable in the context of green chemistry.…”

Design, Regiospecific Green Synthesis, Chemical Computational Analysis, and Antimicrobial Evaluation of Novel Phthalazine Heterocycles

“…Some of O ‐alkyl‐phthalazine derivatives were monitored in vitro for their antimicrobial effect, and the energy variance between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) plays a significant role in the electronic studies of these molecules by quantum chemical calculations that reflects the relation between delocalization, electron distribution, and chemical reactivity with kinetic stability of the compound . Phthalazine derivatives were announced to acquire anticonvulsant , antitumor , antihypertensive, antithrombotic , antidiabetic , antitrypanosomal , anti‐inflammatory , cardiotonic , and vasorelaxant activities. Therefore, various strategies have been accounted for the synthesis of phthalazine derivatives .…”

Eco-friendlyone-potsynthesis of some new pyrazolo[1,2-b]phthalazinediones with antiproliferative efficacy on human hepatic cancer cell lines

“…Hence, the development of new methods for the synthesis of pyrazoles, triazoles and phthalazines continues to be an active area of research. Nevertheless, multi-component reactions were considered as an excellent tool for synthesis of complex heterocycles owing to their advantages of the structure diversity, simpler procedures, intrinsic atom economy, energy saving and reduced waste (28)(29)(30)(31)(32)(33)(34).…”